DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIA and Grin3b

DIOPT Version :9

Sequence 1:NP_523484.2 Gene:GluRIIA / 33788 FlyBaseID:FBgn0004620 Length:907 Species:Drosophila melanogaster
Sequence 2:NP_579842.2 Gene:Grin3b / 170796 RGDID:621705 Length:1002 Species:Rattus norvegicus


Alignment Length:885 Identity:188/885 - (21%)
Similarity:320/885 - (36%) Gaps:225/885 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 PTNDSFLLQQITCELIS--NGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQE---- 132
            ||.|...|.:..|::::  ..||:|..|.::....::..:|.||..|.:      ...|:|    
  Rat    80 PTRDPASLARGLCQVLAPPGVVASIAFPEARPELRLLQFLAAATETPVV------SVLRREVRTA 138

  Fly   133 ---QLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDY-- 192
               .....:.::.|..|..:......:::: :.|....|:      |.|::|..::..|.:::  
  Rat   139 LGAPTPFHLQLDWASPLETILDVLVSLVRA-HAWEDIALV------LCRVRDPGSLVTLWTNHAS 196

  Fly   193 ------VKLRNLADYADDYR----ILWK-ETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPF 246
                  :.|..|....|..|    :|.. |...|.....::|.|......|:|:.:      .|.
  Rat   197 QAPKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVPAAVLLGCSTARAHEVLEAA------PPG 255

  Fly   247 RNWFL-THLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILG--NQTMLPI 308
            ..|.| |.|.                         .:|.|    .|.|......||  .|..|..
  Rat   256 PQWLLGTPLP-------------------------AEALP----TTGLPPGVLALGETEQHSLEA 291

  Fly   309 LIYDAVVLFASSARNVIAAMQPFHPPN-------------------------RHCGSSS------ 342
            :::|.|.|.|.:    :::|...||..                         |..|::|      
  Rat   292 VVHDMVELVAQA----LSSMALVHPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTG 352

  Fly   343 -PWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKK 406
             .|:.|:         |:..|..|||..:::.|..|                 ...|......:.
  Rat   353 AVWVTGS---------SQVHVSRHFKVWSLRRDPLG-----------------APAWATVGSWQD 391

  Fly   407 RLLN-------LELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHEN---------------- 448
            ..|:       |.:.|...||    .|....|||..|.|:...:|..|:                
  Rat   392 GQLDFQPGAAALRVPSPSGTQ----ARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTND 452

  Fly   449 -----------FRG------REKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNP-ETKQWDGI 495
                       ..|      |....||.:||:.:|:|.:.||:|..|| |:|||.. ...:|.|:
  Rat   453 SARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIV-GDGKYGALRDGRWTGL 516

  Fly   496 IRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISIL-HYKSPPEPKNQFAFLEPFAVEVWI 559
            :..|:...|.:.|...:|...|..|||||.||....:.|: ..:....|..  ||:.|....:|:
  Rat   517 VGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIG--AFMWPLHWSMWV 579

  Fly   560 YMIFAQLIMTLAFVFIARLSYREWLPP---NPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDIL 621
             .:||.|.:|..|     |:..||..|   .|.           ..|..|.....|.:.....||
  Rat   580 -GVFAALHLTALF-----LTLYEWRSPYGLTPR-----------GRNRGTVFSYSSALNLCYAIL 627

  Fly   622 ---------PRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFG 677
                     |:.|..|.|..:|..|.|::||:|||||||.:..:|....:..:.|    .|:|..
  Rat   628 FGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHD----PKLHHP 688

  Fly   678 SMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGY-AFLMETTSLTY- 740
            | :|......:..|.:...:.::.:|..........|...|||.:..:.... ||:|:.:.|.| 
  Rat   689 S-QGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYE 752

  Fly   741 -NIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDS 804
             :|:.:|.|..:|:....:.||:.:|..|...:|||..|.:....|.:..:.:||:|  .|.|..
  Rat   753 VSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYK--MVPCGK 815

  Fly   805 --YHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLW 842
              :...:..::.:....|:|::|..|:...::..:.|.::
  Rat   816 RVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVF 855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIIANP_523484.2 PBP1_iGluR_Kainate 33..404 CDD:107377 67/386 (17%)
ANF_receptor 46..386 CDD:279440 66/368 (18%)
PBP2_iGluR_Kainate 426..796 CDD:270432 108/419 (26%)
Lig_chan 556..828 CDD:278489 70/288 (24%)
Grin3bNP_579842.2 PBP1_iGluR_NMDA_NR3 21..405 CDD:107372 69/402 (17%)
PBP2_iGluR_NMDA_Nr3 414..808 CDD:270438 107/418 (26%)
Lig_chan 576..842 CDD:278489 70/289 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 882..910
Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250 951..984
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166349737
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.930

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