DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and gria2b

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	918	Identity:	277/918 - (30%)
Similarity:	447/918 - (48%)	Gaps:	140/918 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTN 76
            |.:|..|.| :..||..  .:.:|.:|.....: |.|   ||| :..::|....|    |..|..
Zfish     9 ICLIALLLG-MTTGGSP--SVQIGGLFPRGADQ-EYS---AFR-IGMVQFGTAEF----RLTPHI 61

  Fly    77 D------SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLN 135
            |      ||.:....|...|.||.||||...|.:.:.:........:..|.....|:.      |
Zfish    62 DNLEVANSFAVTNCFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPLDG------N 120

  Fly   136 HQMSINVAPSLS--VLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNL 198
            .|..|.:.|.:.  :||...:      |:|..|..:|::..||..||.:::..|.....|...|:
Zfish   121 QQFIIQMRPDIKGPLLSLIEY------YKWDKFAYLYDSDRGLTTLQVVLDTAAEKKWQVTAINV 179

  Fly   199 ADYADD-----YRILWKETDETFHEQRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTHLDT 256
            .:..|:     ||.|:::. |...|:|:|||||...:|::::  ::|...::|  .::.:.:|..
Zfish   180 GNMKDERKDEAYRSLFQDL-ENKKERRVILDCEQDKVKDIMEQVITIGRHVKG--YHYIIANLGF 241

  Fly   257 HNSGLRDI-YNEDFKANITSVRLKVVD-----ANPFERK--------------KTRLTKVDQILG 301
            .:..|..| |.   .||::.  .::||     .:.|:::              |.|.|..
Zfish   242 VDGDLSKIQYG---GANVSG--FQIVDFDDPLVSKFDQRWEALEEKEYPGADSKIRYTSA----- 296

  Fly   302 NQTMLPILIYDAVVLFASSARNVIAAMQPFHPP---------NRHC--GSSSPWMLGAFIVNEMK 355
                   |.||||.:...:.|.:       |..         |..|  ..:.||..|..|...:|
Zfish   297 -------LTYDAVQVMTEAFRYL-------HKQRIDISRRANNGDCLANPAVPWAQGVEIERALK 347

  Fly   356 TISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNLELESAGT 418
            .:..|.:     |.|::.|:||:|:::.:.:.:...|..:.:  |   |.:.|.::        |
Zfish   348 QVRVDGL-----TGNIQFDQYGKRVNYTVNVMELKSNGAVKIGYW---NEVDKMVV--------T 396

  Fly   419 TQD------FSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFM 477
            ..|      ...:.|...|.|..|.||.|:|::.:.|...|:||||.|||.:::::...|.|:..
Zfish   397 KSDLFPNDTMGLENKTVIVTTILEAPYVMLKKNADLFMDNERYEGYCVDLAAEIAKHCGFKYQLK 461

  Fly   478 IVNGNGKY---NPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKS 539
            || |:|||   :.|||.|:|::.:|:...|.|.|..||||.:|..|:||:.|||.|||||:..|.
Zfish   462 IV-GDGKYGARDAETKIWNGMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKP 525

  Fly   540 PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLP---PNPAIQDPDELENIWN 601
            .......|:||:|.|.|:|:.::||.:.:::....::|.|..||..   .:..|| .:|..|.:.
Zfish   526 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEYEDGQIQ-TNESTNEFG 589

  Fly   602 VNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQ 666
            :.||.|..:|:.|:|||||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:
Zfish   590 IFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAE 654

  Fly   667 DLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAF 731
            ||.:|.::.:|::..|||..||..|....:.:.|..||...||.|..|..|||.||||.||.||:
Zfish   655 DLAKQTEIAYGTLDSGSTKEFFRRSKIALFDKMWTYMKGAEPSVFVKTTAEGVMRVRKSKGKYAY 719

  Fly   732 LMETTSLTYNIERN-CDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWW 795
            |:|:|...|..:|. ||..::|..:..|.||:|.|.||..|..:::::|:|:|:|.|.|:|||||
Zfish   720 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWW 784

  Fly   796 KNHNVTCDSYHEVDGDE------LSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVT 854
            .:.. .|.|   ..||.      ||:..:.|||.:|.||:.:.:::.:.||.:..:..|...:||
Zfish   785 YDKG-ECGS---GGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKRMKVT 845

  Fly   855 PWQAFKAE 862
            ...|.:::
Zfish   846 FSDAMRSK 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	93/418 (22%)
		ANF_receptor	46..386	CDD:279440	88/385 (23%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	156/376 (41%)
		Lig_chan	556..828	CDD:278489	111/281 (40%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	94/423 (22%)
		ANF_receptor	55..377	CDD:279440	82/369 (22%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	157/382 (41%)
		Lig_chan	542..820	CDD:278489	112/282 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591077
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740