DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and gria2a

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	903	Identity:	270/903 - (29%)
Similarity:	439/903 - (48%)	Gaps:	129/903 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTND------SFL 80
            :||||..  .:.:|.:|.....: |.|   ||| :..::|....|    |..|..|      ||.
Zfish    14 LALGGSP--SVQIGGLFPRGADQ-EYS---AFR-IGMVQFGTAEF----RLTPHIDNLEVANSFA 67

  Fly    81 LQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPS 145
            :....|...|.||.||||...|.:.:.:........:..|......:...|..|..:..|. .|.
Zfish    68 ITNCFCSQFSRGVYAIFGFYDKKSVNTITSFCETLHVSFITPSFPADGLNQFVLQMRPDIK-GPL 131

  Fly   146 LSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADD-----Y 205
            :|::         ..|:|..|..:|::..||:.||.:::..|.....|...|:.:..|:     |
Zfish   132 ISLV---------EYYKWEKFAYLYDSDRGLSTLQAVLDTAAERKWQVTAINVGNLKDEWKDEAY 187

  Fly   206 RILWKETDETFHEQRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNED 268
            |.|:::. |..:|:|:|||||...:|::::  ::|...::|       .|....|.|..|   .|
Zfish   188 RSLFQDL-ENKNERRVILDCEQDKVKDIMEQVITIGRHVKG-------YHYIIANFGFVD---GD 241

  Fly   269 FK------ANITSVRLKVVDAN-----PFERKKTRLTKVDQILGNQTML---PILIYDAVVLFAS 319
            ..      ||::.  .::||.:     .|:::...|.: .:..|..:.:   ..|.||||.:...
Zfish   242 LSKIQYGGANVSG--FQIVDFDDPLVAKFDQRWEALEE-KEYPGADSRIRYTSALTYDAVQVMTE 303

  Fly   320 SARNVIAAMQPFHPP---------NRHC--GSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKL 373
            :.|.:       |..         |..|  ..:.||..|..|...:|.:..|.:     |.|::.
Zfish   304 AFRFL-------HKQRIDISRRGNNGDCLANPAVPWAQGVEIERALKQVRVDGL-----TGNIQF 356

  Fly   374 DEYGQRIHFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNLELESAGTTQD-------FSEQRKVY 429
            |:||:|:::.:.:.:...:.|:.:  |.            |::....|:.       ...:.|..
Zfish   357 DQYGRRVNYTVNVMELKNSGPVKIGYWN------------EMDKMAVTKSDLFPNDTMGMENKTV 409

  Fly   430 TVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQ 491
            .|.|..|.||.|:|::.|.|...|:||||.|||.:::::...|.|:..|| .:|||   :.|||.
Zfish   410 IVTTILEAPYVMLKKNAELFTDNERYEGYCVDLAAEIAKHCGFKYQLRIV-ADGKYGARDAETKI 473

  Fly   492 WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVE 556
            |:|::.:|:...|.|.|..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.|
Zfish   474 WNGMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYE 538

  Fly   557 VWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQD----PDELENIWNVNNSTWLMVGSIMQQG 617
            :|:.::||.:.:::....::|.|..||  .....:|    |.|..|.:.:.||.|..:|:.||||
Zfish   539 IWMCIVFAYIGVSVVLFLVSRFSPYEW--HTEEFEDGQLGPSESTNEFGIFNSLWFSLGAFMQQG 601

  Fly   618 CDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGG 682
            |||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::..|
Zfish   602 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAG 666

  Fly   683 STSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN-C 746
            ||..||..|....:.:.|..||...||.|.....|||.||||.||.||:|:|:|...|..:|. |
Zfish   667 STKEFFRRSKIALFDKMWQYMKSAEPSVFVKNTVEGVLRVRKSKGKYAYLLESTMNEYIEQRKPC 731

  Fly   747 DLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGD 811
            |..::|..:..|.||:|.|.||..|..:::::|:|:|:|.|.|:|||||.:.. .|.|    .|.
Zfish   732 DTMKVGGNLDSKGYGIATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKG-ECGS----GGG 791

  Fly   812 E-------LSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAE 862
            |       ||:..:.|||.:|.||:.:.:::.:.||.:..:..|...::|...|.:::
Zfish   792 ESKEKTSALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKRMKMTFTDAMRSK 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	90/410 (22%)
		ANF_receptor	46..386	CDD:279440	86/377 (23%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	156/377 (41%)
		Lig_chan	556..828	CDD:278489	111/283 (39%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	91/424 (21%)
		ANF_receptor	51..373	CDD:279440	80/361 (22%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	157/379 (41%)
		Lig_chan	538..816	CDD:278489	112/284 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740