Protein Alignment GluRIIA and Grin2d

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_036008580.1
• Gene: Grin2d / 14814
• MGIID: 95823
• Length: 1345
• Species: Mus musculus
• Alignment Length: 826
• Identity: 179/826 - (21%)
• Similarity: 327/826 - (39%)
• Gaps: 190/826 - (23%)

  Fly   124 LKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEG----LARLQDLMN 184
            |:|.::.::||                :..||::: .|:|.:|..:.....|    |:.::.|.:
Mouse   164 LQLGSSTEQQL----------------QVIFEVLE-EYDWTSFVAVTTRAPGHRAFLSYIEVLTD 211

  Fly   185 IQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNW 249
            ...:..::.....|...|.: .:|..:......:.|::. |..:..:.:.:.:.:..|.||...|
Mouse   212 GSLVGWEHRGALTLDPGAGE-AVLGAQLRSVSAQIRLLF-CAREEAEPVFRAAEEAGLTGPGYVW 274

  Fly   250 FLTHLDTHNSGLRDIYNE--------DFKANITSVRLKVVDANPFERKKTRLTKV----DQILGN 302
            |:........|...:..|        ...|.:.:||......:...|....:..|    ..:|.:
Mouse   275 FMVGPQLAGGGGSGVPGEPLLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRD 339

  Fly   303 QTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFK 367
            ...||.|.:|.      .|:|           ..|.|.|    |..:.:|    |:.|:.:..|
Mouse   340 YGFLPELGHDC------RAQN-----------RTHRGES----LHRYFMN----ITWDNRDYSF- 378

  Fly   368 TENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLE----------LESAGTTQDF 422
                  :|.|..::.:|.:...|.:.   .|......:::.|.|:          |:....||..
Mouse   379 ------NEDGFLVNPSLVVISLTRDR---TWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHL 434

  Fly   423 SEQRKVYTVVTHYEEPYFMMKEDHENFRGR-------------------------------EK-- 454
                   ||.|..|.| |::.|..:...|.                               ||
Mouse   435 -------TVATLEERP-FVIVEPADPISGTCIRDSVPCRSQLNRTHSLVAPRSPPPDAPRPEKRC 491

  Fly   455 YEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMRR 518
            .:|:.:|::.:|:..:.|.|:..:|. |||:..:.. .|:|:|.::....|.:.:..|||.:.|.
Mouse   492 CKGFCIDILKRLAHTIGFSYDLYLVT-NGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERS 555

  Fly   519 SVVDFTVPFMQLGISILHYKS----PPEPKNQFAFL------EPFAVEVWIYMIFAQLIMTLAFV 573
            .:|||:|||::.|||::..:|    .|.....||:|      ||::..||:.|....|.:....|
Mouse   556 EIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLMPPMSPEPYSPAVWVMMFVMCLTVVAVTV 620

  Fly   574 FIARLSYREWLPP---NPAI---QDPDELENIWNVNNSTWLMVGSIMQQGCDI-LPRGPHMRILT 631
            ||.     |:|.|   |.::   :.|.  .:.:.:..|.||:...:......: .|||...:|:.
Mouse   621 FIF-----EYLSPVGYNRSLATGKRPG--GSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMV 678

  Fly   632 GMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQ------DKVHFGSMRGGSTSLFFSE 690
            .:|.|||::.|::||||||||:...::..::..|.|...|      ..:.||::..|||.... .
Mouse   679 LVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNI-R 742

  Fly   691 SNDTD---YQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN--CDLTQ 750
            ||..|   |...:||.:          .:|.:.:::..|.. ||:.:...|.|...::  |.|..
Mouse   743 SNYPDMHSYMVRYNQPR----------VEEALTQLKAGKLD-AFIYDAAVLNYMARKDEGCKLVT 796

  Fly   751 I--GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HNVTCDSYHEVDGD 811
            |  |:......||:|:..||.::..:.:::||.....|::.::..|...  ||   |.. ||...
Mouse   797 IGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHN---DKI-EVMSS 857

  Fly   812 ELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQ 857
            :|.|..:.|||.:|    |:.:.|.:..|.|        |.:..|:
Mouse   858 KLDIDNMAGVFYML----LVAMGLSLLVFAW--------EHLVYWR 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	49/296 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	108/433 (25%)
		Lig_chan	555..828	CDD:459656	76/294 (26%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:471960	51/304 (17%)
		PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	109/444 (25%)