DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Grin2d

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_036008580.1	Gene:	Grin2d / 14814	MGIID:	95823	Length:	1345	Species:	Mus musculus

Alignment Length:	826	Identity:	179/826 - (21%)
Similarity:	327/826 - (39%)	Gaps:	190/826 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 LKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEG----LARLQDLMN 184
            |:|.::.::||                :..||::: .|:|.:|..:.....|    |:.::.|.:
Mouse   164 LQLGSSTEQQL----------------QVIFEVLE-EYDWTSFVAVTTRAPGHRAFLSYIEVLTD 211

  Fly   185 IQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNW 249
            ...:..::.....|...|.: .:|..:......:.|::. |..:..:.:.:.:.:..|.||...|
Mouse   212 GSLVGWEHRGALTLDPGAGE-AVLGAQLRSVSAQIRLLF-CAREEAEPVFRAAEEAGLTGPGYVW 274

  Fly   250 FLTHLDTHNSGLRDIYNE--------DFKANITSVRLKVVDANPFERKKTRLTKV----DQILGN 302
            |:........|...:..|        ...|.:.:||......:...|....:..|    ..:|.:
Mouse   275 FMVGPQLAGGGGSGVPGEPLLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRD 339

  Fly   303 QTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFK 367
            ...||.|.:|.      .|:|           ..|.|.|    |..:.:|    |:.|:.:..|
Mouse   340 YGFLPELGHDC------RAQN-----------RTHRGES----LHRYFMN----ITWDNRDYSF- 378

  Fly   368 TENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLE----------LESAGTTQDF 422
                  :|.|..::.:|.:...|.:.   .|......:::.|.|:          |:....||..
Mouse   379 ------NEDGFLVNPSLVVISLTRDR---TWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHL 434

  Fly   423 SEQRKVYTVVTHYEEPYFMMKEDHENFRGR-------------------------------EK-- 454
                   ||.|..|.| |::.|..:...|.                               ||
Mouse   435 -------TVATLEERP-FVIVEPADPISGTCIRDSVPCRSQLNRTHSLVAPRSPPPDAPRPEKRC 491

  Fly   455 YEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMRR 518
            .:|:.:|::.:|:..:.|.|:..:|. |||:..:.. .|:|:|.::....|.:.:..|||.:.|.
Mouse   492 CKGFCIDILKRLAHTIGFSYDLYLVT-NGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERS 555

  Fly   519 SVVDFTVPFMQLGISILHYKS----PPEPKNQFAFL------EPFAVEVWIYMIFAQLIMTLAFV 573
            .:|||:|||::.|||::..:|    .|.....||:|      ||::..||:.|....|.:....|
Mouse   556 EIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLMPPMSPEPYSPAVWVMMFVMCLTVVAVTV 620

  Fly   574 FIARLSYREWLPP---NPAI---QDPDELENIWNVNNSTWLMVGSIMQQGCDI-LPRGPHMRILT 631
            ||.     |:|.|   |.::   :.|.  .:.:.:..|.||:...:......: .|||...:|:.
Mouse   621 FIF-----EYLSPVGYNRSLATGKRPG--GSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMV 678

  Fly   632 GMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQ------DKVHFGSMRGGSTSLFFSE 690
            .:|.|||::.|::||||||||:...::..::..|.|...|      ..:.||::..|||.... .
Mouse   679 LVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNI-R 742

  Fly   691 SNDTD---YQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN--CDLTQ 750
            ||..|   |...:||.:          .:|.:.:::..|.. ||:.:...|.|...::  |.|..
Mouse   743 SNYPDMHSYMVRYNQPR----------VEEALTQLKAGKLD-AFIYDAAVLNYMARKDEGCKLVT 796

  Fly   751 I--GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HNVTCDSYHEVDGD 811
            |  |:......||:|:..||.::..:.:::||.....|::.::..|...  ||   |.. ||...
Mouse   797 IGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHN---DKI-EVMSS 857

  Fly   812 ELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQ 857
            :|.|..:.|||.:|    |:.:.|.:..|.|        |.:..|:
Mouse   858 KLDIDNMAGVFYML----LVAMGLSLLVFAW--------EHLVYWR 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	49/295 (17%)
		ANF_receptor	46..386	CDD:279440	47/277 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	108/433 (25%)
		Lig_chan	556..828	CDD:278489	76/293 (26%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822	51/304 (17%)
Grin2d	XP_036008580.1	PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	109/444 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830