Protein Alignment GluRIIA and Grin2c

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_017169765.1
• Gene: Grin2c / 14813
• MGIID: 95822
• Length: 1307
• Species: Mus musculus
• Alignment Length: 978
• Identity: 212/978 - (21%)
• Similarity: 384/978 - (39%)
• Gaps: 241/978 - (24%)

  Fly    12 IIIIGFLEGIIALG-GDDRNEITVGAIF---------------YENEKEIELSFDQAFREVNNMK 60
            :::...|.....|| |.....:||..:|               .:|..::.|........|||
Mouse    71 LLLTSLLGAWAGLGAGQGEQAVTVAVVFGSSGPLQAQARTRLTPQNFLDLPLEIQPLTIGVNN-- 133

  Fly    61 FSELRFVTIKRYMPTNDSFLLQQITCELISNGVAAIFG------PSSKAASDIVAQIANATGIPH 119
                          ||.|.:|.|| |.|:  |.|.:.|      ..::|.:.::..:::.|.:|.
Mouse   134 --------------TNPSSILTQI-CGLL--GAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPI 181

  Fly   120 IEYD----LKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQ 180
            :...    :.|..........|:.:::...|.||    |:::: .|:|..|.:|.....|.|..
Mouse   182 LSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVL----FKVLE-EYDWSAFAVITSLHPGHALF- 240

  Fly   181 DLMNIQAL-NSDYVKLRNL----------ADYADDYRILWKETDETFHEQRIILDCEPKTLKELL 234
             |..::|: ::.|:..|.|          ...|...|:| ::.|...    ::..|..:..:.|.
Mouse   241 -LEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLL-RQVDAPV----LVAYCSREEAEVLF 299

  Fly   235 KVSIDFKLQGPFRNWFLTHLDTHNS---------GLRDIYNEDFKANITSVRLKVVD-------- 282
            ..:....|.||...|.:.:|...::         ||..:..|.::   .|:|.||.|
Mouse   300 AEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVTESWR---LSLRQKVRDGVAILALG 361

  Fly   283 ANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARN----VIAAMQPFHPPNRHC----- 338
            |:.:.|:                     |..:...|...|:    |..|.:.|:   ||.
Mouse   362 AHSYRRQ---------------------YGTLPAPAGDCRSHPGPVSPAREAFY---RHLLNVTW 402

  Fly   339 -GSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDN 402
             |....:..|.::|.....:                          :.:.:..:.|.:..|  |:
Mouse   403 EGRDFSFSPGGYLVQPTMVV--------------------------IALNRHRLWEMVGRW--DH 439

  Fly   403 GIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMM------------------KEDHENF 449
            |:......:....:.:.|...:.|.: ||.|..|.|:.::                  ::.:..|
Mouse   440 GVLYMKYPVWPRYSTSLQPVVDSRHL-TVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTF 503

  Fly   450 RGRE--KY-----EGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQI 506
            ...:  .|     :|:.:|::.||:::::|.|:..:|. |||:....: .|:|:|.::....|.:
Mouse   504 SSGDITPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVT-NGKHGKRVRGVWNGMIGEVYYKRADM 567

  Fly   507 GVCDLTITQMRRSVVDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMT 569
            .:..|||.:.|..::||:|||::.|||::..:|  ...|.   |||||::..||: |:|...:..
Mouse   568 AIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWV-MMFVMCLTV 628

  Fly   570 LA-----FVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDI-LPRGPHMR 628
            :|     |.:.:.:||.:.|........|.     :.:..|.||:...:......| .|||...:
Mouse   629 VAITVFMFEYFSPVSYNQNLTKGKKSGGPS-----FTIGKSVWLLWALVFNNSVPIENPRGTTSK 688

  Fly   629 ILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQD---LIEQDK---VHFGSMRGGSTSLF 687
            |:..:|.|||::.|::||||||||:...::..::..|.|   ...||:   ..||::..|||
Mouse   689 IMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGST--- 750

  Fly   688 FSESN-DTDYQRAWNQMKDFN----PSAFTSTNKEGVARVRKEKGGYAFLMETTSLTY--NIERN 745
              |.| .::|:.....|..||    ..|.||. |.|...|.::..  ||:.:...|.|  ..:..
Mouse   751 --ERNIRSNYRDMHTHMVKFNQRSVEDALTSL-KMGARHVSRKLD--AFIYDAAVLNYMAGKDEG 810

  Fly   746 CDLTQI--GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HNVTCDSYH 806
            |.|..|  |:......||:|:...|.::..:.:::||....||.||::..|...  ||    ..:
Mouse   811 CKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICHN----EKN 871

  Fly   807 EVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQ-----AFKAELIFA 866
            ||...:|.|..:.|||.:|    |:.:.|.:..|.|        |.:..|:     ...::|.|.
Mouse   872 EVMSSKLDIDNMAGVFYML----LVAMGLALLVFAW--------EHLVYWKLRHSVPSSSQLDFL 924

  Fly   867 LKF 869
            |.|
Mouse   925 LAF 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	75/434 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	112/418 (27%)
		Lig_chan	555..828	CDD:459656	81/295 (27%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	75/441 (17%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	112/424 (26%)
		NMDAR2_C	905..>980	CDD:463148	5/23 (22%)