Protein Alignment GluRIIA and Grin2b

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_032197.3
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 911
• Identity: 203/911 - (22%)
• Similarity: 349/911 - (38%)
• Gaps: 239/911 - (26%)

  Fly    75 TNDSFLLQQITCELISN----GVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLN 135
            |:...::.:| |:|:|:    ||........:|.:.|:..|:..|..|.:...........::..
Mouse    76 TDPKSIITRI-CDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDE 139

  Fly   136 HQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRN--- 197
            ..|.....||:...:.....|:: .|:|..|:::.....|   .||.:|         |:|:
Mouse   140 SSMFFQFGPSIEQQASVMLNIME-EYDWYIFSIVTTYFPG---YQDFVN---------KIRSTIE 191

  Fly   198 ------------LADYADDYRILWKETDETFHEQR-------IILDCEPKTLKELLKVSIDFKLQ 243
                        |.|.:.|      :.|.....|.       |:|.|..:....:.:|:....|.
Mouse   192 NSFVGWELEEVLLLDMSLD------DGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLT 250

  Fly   244 GPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPI 308
            |....|.:..|   .:|..|....:|...:.||.....|..                     ||.
Mouse   251 GYGYTWIVPSL---VAGDTDTVPSEFPTGLISVSYDEWDYG---------------------LPA 291

  Fly   309 LIYDAVVLFASSARNVIAAMQPFHPPNRHCGSS------SPWMLGAFIVNEMKTISEDDVEPHFK 367
            .:.|.:.:..::|.::::.......|...|.::      ...||..:::|..           |:
Mouse   292 RVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVT-----------FE 345

  Fly   368 TENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLE--LESAGTTQDFSEQRKVY- 429
            ..|:...|.|.::|..|.|.                    |||.|  .|..|..:|.|.|.|.|
Mouse   346 GRNLSFSEDGYQMHPKLVII--------------------LLNKERKWERVGKWKDKSLQMKYYV 390

  Fly   430 ----------------TVVTHYEEPYFMM-------------------------KEDHENFRGRE 453
                            ::||..|.|:.::                         |.|.|....::
Mouse   391 WPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKK 455

  Fly   454 KYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMR 517
            ..:|:.:|::.|:|:.::|.|:..:|. |||:..:.. .|:|:|.:::...|.:.|..|||.:.|
Mouse   456 CCKGFCIDILKKISKSVKFTYDLYLVT-NGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEER 519

  Fly   518 RSVVDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFI----A 576
            ..||||:|||::.|||::..:|  ...|.   ||||||:.:||:.|....||::...||:    :
Mouse   520 SEVVDFSVPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFS 581

  Fly   577 RLSYREWL-----PPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDIL-PRGPHMRILTGMWW 635
            .:.|...|     |..|:          :.:..:.||:.|.:......:. |:|...:|:..:|.
Mouse   582 PVGYNRCLADGREPGGPS----------FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 636

  Fly   636 FFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQ------DKVHFGSMRGGSTSLFFSESN-D 693
            |||::.|::||||||||:...::...:..|.|...|      ....||::..|||     |.| .
Mouse   637 FFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST-----ERNIR 696

  Fly   694 TDYQRAWNQMKDFNPSAFTSTNKEGV--ARVRKEKGGY-AFLMETTSLTYNIERN--CDLTQI-- 751
            .:|......|..|        |:.||  |.:..:.|.. ||:.:...|.|...|:  |.|..|
Mouse   697 NNYAEMHAYMGKF--------NQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGS 753

  Fly   752 GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HNVTCDSYHEVDGDELS 814
            |:......||:|:...|.::..:.::||||...||:::::..|...  ||    ..:||...:|.
Mouse   754 GKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHN----EKNEVMSSQLD 814

  Fly   815 IIELGGVFLVLAGGVLIGVILGIFE--FLWN--------------------------VQNVAVEE 851
            |..:.|||.:|...:.:.:|..|.|  |.|.                          :..||:||
Mouse   815 IDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEE 879

  Fly   852 R 852
            |
Mouse   880 R 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	60/361 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	114/438 (26%)
		Lig_chan	555..828	CDD:459656	78/298 (26%)
Grin2b	NP_032197.3	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	69/386 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	112/426 (26%)
		NMDAR2_C	840..1482	CDD:463148	7/41 (17%)