DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIA and Grin2b

DIOPT Version :9

Sequence 1:NP_523484.2 Gene:GluRIIA / 33788 FlyBaseID:FBgn0004620 Length:907 Species:Drosophila melanogaster
Sequence 2:NP_001350679.1 Gene:Grin2b / 14812 MGIID:95821 Length:1482 Species:Mus musculus


Alignment Length:911 Identity:203/911 - (22%)
Similarity:349/911 - (38%) Gaps:239/911 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 TNDSFLLQQITCELISN----GVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLN 135
            |:...::.:| |:|:|:    ||........:|.:.|:..|:..|..|.:...........::..
Mouse    76 TDPKSIITRI-CDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDE 139

  Fly   136 HQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRN--- 197
            ..|.....||:...:.....|:: .|:|..|:::.....|   .||.:|         |:|:   
Mouse   140 SSMFFQFGPSIEQQASVMLNIME-EYDWYIFSIVTTYFPG---YQDFVN---------KIRSTIE 191

  Fly   198 ------------LADYADDYRILWKETDETFHEQR-------IILDCEPKTLKELLKVSIDFKLQ 243
                        |.|.:.|      :.|.....|.       |:|.|..:....:.:|:....|.
Mouse   192 NSFVGWELEEVLLLDMSLD------DGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLT 250

  Fly   244 GPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPI 308
            |....|.:..|   .:|..|....:|...:.||.....|..                     ||.
Mouse   251 GYGYTWIVPSL---VAGDTDTVPSEFPTGLISVSYDEWDYG---------------------LPA 291

  Fly   309 LIYDAVVLFASSARNVIAAMQPFHPPNRHCGSS------SPWMLGAFIVNEMKTISEDDVEPHFK 367
            .:.|.:.:..::|.::::.......|...|.::      ...||..:::|..           |:
Mouse   292 RVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVT-----------FE 345

  Fly   368 TENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLE--LESAGTTQDFSEQRKVY- 429
            ..|:...|.|.::|..|.|.                    |||.|  .|..|..:|.|.|.|.| 
Mouse   346 GRNLSFSEDGYQMHPKLVII--------------------LLNKERKWERVGKWKDKSLQMKY
YV 390

  Fly   430 ----------------TVVTHYEEPYFMM-------------------------KEDHENFRGRE 453
                            ::||..|.|:.::                         |.|.|....::
Mouse   391 WPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKK 455

  Fly   454 KYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMR 517
            ..:|:.:|::.|:|:.::|.|:..:|. |||:..:.. .|:|:|.:::...|.:.|..|||.:.|
Mouse   456 CCKGFCIDILKKISKSVKFTYDLYLVT-NGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEER 519

  Fly   518 RSVVDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFI----A 576
            ..||||:|||::.|||::..:|  ...|.   ||||||:.:||:.|....||::...||:    :
Mouse   520 SEVVDFSVPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFS 581

  Fly   577 RLSYREWL-----PPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDIL-PRGPHMRILTGMWW 635
            .:.|...|     |..|:          :.:..:.||:.|.:......:. |:|...:|:..:|.
Mouse   582 PVGYNRCLADGREPGGPS----------FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 636

  Fly   636 FFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQ------DKVHFGSMRGGSTSLFFSESN-D 693
            |||::.|::||||||||:...::...:..|.|...|      ....||::..|||     |.| .
Mouse   637 FFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST-----ERNIR 696

  Fly   694 TDYQRAWNQMKDFNPSAFTSTNKEGV--ARVRKEKGGY-AFLMETTSLTYNIERN--CDLTQI-- 751
            .:|......|..|        |:.||  |.:..:.|.. ||:.:...|.|...|:  |.|..|  
Mouse   697 NNYAEMHAYMGKF--------NQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGS 753

  Fly   752 GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HNVTCDSYHEVDGDELS 814
            |:......||:|:...|.::..:.::||||...||:::::..|...  ||    ..:||...:|.
Mouse   754 GKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHN----EKNEVMSSQLD 814

  Fly   815 IIELGGVFLVLAGGVLIGVILGIFE--FLWN--------------------------VQNVAVEE 851
            |..:.|||.:|...:.:.:|..|.|  |.|.                          :..||:||
Mouse   815 IDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEE 879

  Fly   852 R 852
            |
Mouse   880 R 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIIANP_523484.2 PBP1_iGluR_Kainate 33..404 CDD:107377 60/360 (17%)
ANF_receptor 46..386 CDD:279440 59/342 (17%)
PBP2_iGluR_Kainate 426..796 CDD:270432 114/438 (26%)
Lig_chan 556..828 CDD:278489 78/297 (26%)
Grin2bNP_001350679.1 PBP1_iGluR_NMDA_NR2 33..388 CDD:380601 69/386 (18%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 112/426 (26%)
NMDAR2_C 840..1482 CDD:402274 7/41 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846232
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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