DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Grin2a

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_032196.2	Gene:	Grin2a / 14811	MGIID:	95820	Length:	1464	Species:	Mus musculus

Alignment Length:	991	Identity:	215/991 - (21%)
Similarity:	380/991 - (38%)	Gaps:	257/991 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SFDQAFREVNNMKFSE------LRFVTIKRYMPTNDSFLLQQITCELIS----NGVAAIFGPSS- 101
            |.|...||:.|:...|      |....:...|...|...|....|:|:|    :|:  :||..:
Mouse    43 SHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGL--VFGDDTD 105

  Fly   102 -KAASDIVAQIANATGIP----HIEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNY 161
             :|.:.::..|::.|.||    |....:.:..........|...::....:|:.:     |..:|
Mouse   106 QEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLK-----IMQDY 165

  Fly   162 EWRTFTLIYETPEGLARL--------------QDLMNIQALNSDY------VKLRNLADYADDYR 206
            :|..|:|:.....|....              .|:.|:..|::.:      |:|:.:
Mouse   166 DWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKI-------- 222

  Fly   207 ILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKA 271
                      |...|:|.|.......:|..:....|.|....|.:..|   .||..::..::|.:
Mouse   223 ----------HSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSL---VSGNTELIPKEFPS 274

  Fly   272 NITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNR 336
            .:.||.....|.:                     |...:.|.:.:..::|.:::...........
Mouse   275 GLISVSYDDWDYS---------------------LEARVRDGLGILTTAASSMLEKFSYIPEAKA 318

  Fly   337 HCGSSSP------WMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPM 395
            .|...:.      ..|..|:||    ::.|.       :::...|.|.::|..|.:
Mouse   319 SCYGQTEKPETPLHTLHQFMVN----VTWDG-------KDLSFTEEGYQVHPRLVV--------- 363

  Fly   396 MVWTPDNGIKKRLLNLELESAG--TTQDFSEQRKVY----------------TVVTHYEEPYFMM 442
            :|...|.         |.|..|  ..|..|.:..|:                ::||..|.| |::
Mouse   364 IVLNKDR---------EWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAP-FVI 418

  Fly   443 KED-------------------------HENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN 482
            .||                         :|....::..:|:.:|::.|||..::|.|:..:|. |
Mouse   419 VEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVT-N 482

  Fly   483 GKYNPETKQ-WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKS--PPEPK 544
            ||:..:... |:|:|.:::...|.:.|..|||.:.|..||||:|||::.|||::..:|  ...|.
Mouse   483 GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 547

  Fly   545 NQFAFLEPFAVEVWIYMIFAQLIMTLAFVFI----ARLSYREWLPPNPAIQDPDELENIWNVNNS 605
               ||||||:..||:.|....||::...||:    :.:.|...|....|...|.     :.:..:
Mouse   548 ---AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPS-----FTIGKA 604

  Fly   606 TWLMVGSIMQQGCDIL-PRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLI 669
            .||:.|.:......:. |:|...:|:..:|.|||::.|::||||||||:...::...:..|.|..
Mouse   605 IWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKK 669

  Fly   670 EQDKVH-------FGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGV--ARVRKE 725
            .| :.|       ||::..|||..  :..|:..|...:          .|..|:.||  |.|..:
Mouse   670 FQ-RPHDYSPPFRFGTVPNGSTER--NIRNNYPYMHQY----------MTKFNQRGVEDALVSLK 721

  Fly   726 KGGY-AFLMETTSLTYNIERN--CDLTQIGEQ--IGEKHYGLAVPLGSDYRTNLSVSILQLSERG 785
            .|.. ||:.:...|.|...|:  |.|..||..  .....||:|:..||.::..:.:::||....|
Mouse   722 TGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDG 786

  Fly   786 ELQKMKNKWWKN--HNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFE--FLWN--- 843
            |:::::..|...  ||    ..:||...:|.|..:.|||.:||..:.:.:|..|:|  |.|.
Mouse   787 EMEELETLWLTGICHN----EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRF 847

  Fly   844 -----------------------VQNVAVEER-------VTPWQAFKAELIFALKFWVRKKPMRI 878
                                   :..|.:||:       :|..|:...:|:.:.|        .|
Mouse   848 CFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAK--------NI 904

  Fly   879 SSSSDKSSSRRSSGSR 894
            |:.|:.:|||..|..|
Mouse   905 SNMSNMNSSRMDSPKR 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	65/397 (16%)
		ANF_receptor	46..386	CDD:279440	63/379 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	114/432 (26%)
		Lig_chan	556..828	CDD:278489	78/292 (27%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	71/426 (17%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	113/421 (27%)
		HisJ	<458..>541	CDD:223904	30/83 (36%)
		Lig_chan	556..828	CDD:278489	78/293 (27%)
		NMDAR2_C	839..1464	CDD:287527	17/90 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846236
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6205
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.880