DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Grid2

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	919	Identity:	231/919 - (25%)
Similarity:	404/919 - (43%)	Gaps:	144/919 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENEKEIELSFDQAFREVN-NMKFSELRFVTIK-RYMPTNDSFLLQQITCELISNGVA 94
            |.:||||.|:.|:.:..|..|..::| |.:..:...:|.. .::..|:.|...|..|||::.|:.
Mouse    27 IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGIL 91

  Fly    95 AIFGPSSKAASDIVAQIANATGIPHIEYDLKLEAT-------RQEQLNHQMSINVAPSLSVLSRA 152
            |:.......::..:..:|:|..|||:........|       .:...|...:::|.|.: .|:..
Mouse    92 ALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPV-YLNEV 155

  Fly   153 YFEIIKSNYEWRTFTLIYETPEGLARLQDLM-----------------NIQALNS---DYVKLRN 197
            ...:: :.|.|:.|.:.|::...:..:|:.:                 ||..:.:   |.:::..
Mouse   156 ILRVV-TEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEE 219

  Fly   198 LADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLR 262
            |..|.|..|             |.||...|.|.|..:...::..|.....:|.:.:.:.::..::
Mouse   220 LNRYRDTLR-------------RAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQ 271

  Fly   263 DIYNEDFKANITSVRLKV-VDANPFER--------KKTRLTKVDQILGNQTMLPILIYDAVVLFA 318
            ::..... ..:|.:|... |..|..:|        ..:.....|....|..:..:.|||.|:|.|
Mouse   272 ELVRRSI-GRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFAQNMEISNLYIYDTVLLLA 335

  Fly   319 SSARNVIAAMQPFHPPNRHC--GSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIH 381
            ::....:...:.....:..|  .:|.||..|.   :.::||.:..|  :..|.:::..|.|...:
Mouse   336 NAFHKKLEDRKWHSMASLSCIRKNSKPWQGGR---SMLETIKKGGV--NGLTGDLEFGENGGNPN 395

  Fly   382 FNLEIYKPTVNE-------PMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPY 439
            .:.||......|       .:..|.|..|:...|.:.:||:       :.:..|..|||..|||:
Mouse   396 VHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN-------NMRGVVLRVVTVLEEPF 453

  Fly   440 FMMKEDHENFRGR-EKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNP-ETKQWDGIIRKLIDH 502
            .|:.   ||..|: :||:|:::|::..||..:.|:||..:...:...:| |...|:|::.:|:..
Mouse   454 VMVS---ENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFK 515

  Fly   503 HAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLI 567
            .|.||:..||||..|.:|||||..:|...:.:| .:...:..:.||.|.||.:.:|..:....|:
Mouse   516 RADIGISALTITPDRENVVDFTTRYMDYSVGVL-LRRAEKTVDMFACLAPFDLSLWACIAGTVLL 579

  Fly   568 MTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTG 632
            :.|....:      .||.| |.:|.......  .:.||.|.:.||.:|||.::.......|::.|
Mouse   580 VGLLVYLL------NWLNP-PRLQMGSMTST--TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMG 635

  Fly   633 MWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGS-----------MRGGSTSL 686
            .||.|||:::|:||||||||||..:.:|||:|||||.:|..:.:|:           |:|.:..
Mouse   636 AWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPF- 699

  Fly   687 FFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEK-GGYAFLMETTSLTYNI--ERNCDL 748
                ..|:.|.:.|..:...|.|  .:...|..|.::|.| |.|||:.:...|.|..  :.:|..
Mouse   700 ----ERDSMYSQMWRMINRSNGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSF 758

  Fly   749 TQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVD---- 809
            ..:|..:.::.||:|:..||.||...|..||:|.:.|::..:|:|||.. |..||.|..||
Mouse   759 YTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPK-NGQCDLYSSVDAKQK 822

  Fly   810 GDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKK 874
            |..|.|..|.|||.:||.|:::..::.:.|               .|             |.|:|
Mouse   823 GGALDIKSLAGVFCILAAGIVLSCLIAVLE---------------TW-------------WSRRK 859

  Fly   875 PMRISSSSD 883
            ..|:.|..|
Mouse   860 GSRVPSKED 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	78/417 (19%)
		ANF_receptor	46..386	CDD:279440	67/379 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	123/385 (32%)
		Lig_chan	556..828	CDD:278489	94/289 (33%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		63/333 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	79/421 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	123/385 (32%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846244
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740