DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Grid1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	892	Identity:	218/892 - (24%)
Similarity:	388/892 - (43%)	Gaps:	139/892 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENEKEIELSFDQAFREV---NNMKFSELRFVTIKRYMPTNDSFLLQQITCELISNGV 93
            |.:||||.||..:.:..|..|..::   :::..||....:|| .:..|:.|...|..|:|::.|:
Mouse    24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIK-VIEANNPFQAVQEACDLMTQGI 87

  Fly    94 AAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPS-----LSVLSRAY 153
            .|:...:..|:::.:..:.:|..|||      |...|....:.:.:.::.||     .::.||..
Mouse    88 LALVTSTGCASANALQSLTDAMHIPH------LFVQRNPGGSPRTACHLNPSPDGEAYTLASRPP 146

  Fly   154 FEI------IKSNYEWRTFTLIYETPEGLARLQDLM----------NIQALNSDY---------- 192
            ..:      :.:...|:.|.:.|::...:..||..:          ::|.::.:.
Mouse   147 VRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTT 211

  Fly   193 VKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTH 257
            :|...|..|.|..|             |.||...|:.....:..:::..|.....:|...:.:..
Mouse   212 MKTEELNRYRDTLR-------------RAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEIS 263

  Fly   258 NSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQIL-----GNQTMLPI---LIYDAV 314
            :..:.|:.:... ..:|.||.....|...::......::..:|     |...||.|   .:||:|
Mouse   264 DPEILDLVHSAL-GRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSV 327

  Fly   315 VLFASSARNVIAAMQPFHPPNRHC--GSSSPWMLGAFIVNEMKTISEDDVEPHFK--TENMKLDE 375
            ::.|::....:...:.....:.:|  .|:.||..|..:::.:|       :.|..  |..|:..|
Mouse   328 LMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIK-------KGHITGLTGVMEFRE 385

  Fly   376 YGQRIHFNLEIYKPTVNE-------PMMVWTPDNGIK---------KRLLNLELESAGTTQDFSE 424
            .....:...||...|.:|       .:..|..:.|:.         .||..|.|:
Mouse   386 DSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLK---------- 440

  Fly   425 QRKVYTVVTHYEEPYFMMKEDHENFRGREK-YEGYAVDLISKLSELMEFDYE-FMIVNGNGKYNP 487
                  |||..|||:.|:.   ||..|:.| |:|:::|::..|::.:.|.|| :...:|...:..
Mouse   441 ------VVTVLEEPFVMVA---ENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQL 496

  Fly   488 ETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEP 552
            ....|:|:|.:||...|.:.:..:|||..|.|||||:..:|...:.|| .|.|.|..:.|:...|
Mouse   497 HNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGIL-IKKPEEKISIFSLFAP 560

  Fly   553 FAVEVWIYMIFA-QLIMTLAFVF--IARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIM 614
            |...||..:..| .::..|.||.  |..:..:....|.|:...        .::::.|::.|:.:
Mouse   561 FDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRPSASA--------TLHSAIWIVYGAFV 617

  Fly   615 QQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSM 679
            |||.:.......|||:.|.||.|.|::.|:||||||||||.::..:.|::.|||.:|.::.:|::
Mouse   618 QQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGTV 682

  Fly   680 RGGSTSLFFSE------SNDTDYQRAWNQM-KDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTS 737
            |..:...:|..      ..|:.:...|..: |:.......|...||:.:.:  ||.||||.:...
Mouse   683 RDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAK--KGNYAFLWDVAV 745

  Fly   738 LTYN--IERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNV 800
            :.|.  .:.:|.:|.||..|..|.||:|:..||.||...|..||:|.:.|:|..:|.|||. |..
Mouse   746 VEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWP-HTG 809

  Fly   801 TCD----SYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWN 843
            .||    |..:.:|..|.:....|||.:||.|:|:..::...|..||
Mouse   810 RCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALELWWN 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	76/423 (18%)
		ANF_receptor	46..386	CDD:279440	65/385 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	119/383 (31%)
		Lig_chan	556..828	CDD:278489	88/287 (31%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		80/439 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	77/425 (18%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	121/399 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846228
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740