DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and Gria2

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	892	Identity:	283/892 - (31%)
Similarity:	448/892 - (50%)	Gaps:	90/892 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKR 71
            :::..:::...|.|:|.  |...|.|.:|.:|.....: |.|   ||| |..::||...|    |
Mouse     4 IMHISVLLSPVLWGLIF--GVSSNSIQIGGLFPRGADQ-EYS---AFR-VGMVQFSTSEF----R 57

  Fly    72 YMPTND------SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATR 130
            ..|..|      ||.:....|...|.||.||||...|.:.:.:........:..|......:.|
Mouse    58 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT- 121

  Fly   131 QEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKL 195
                 |...|.:.|.   |..|...:|: .|:|..|..:|::..||:.||.:::..|.....|..
Mouse   122 -----HPFVIQMRPD---LKGALLSLIE-YYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTA 177

  Fly   196 RNLADYADD-----YRILWKETDETFHEQRIILDCEPKTLKELLK--VSIDFKLQGPFRNWFLTH 253
            .|:.:..:|     ||.|:::. |...|:|:|||||...:.:::.  ::|...::|       .|
Mouse   178 INVGNINNDKKDETYRSLFQDL-ELKKERRVILDCERDKVNDIVDQVITIGKHVKG-------YH 234

  Fly   254 LDTHNSGLR--DIYNEDF-KANITSVRLKVVDANP------FERKKTRLTKVDQILGNQT----M 305
            ....|.|..  |:....| .||::.  .::||.:.      .||..|...|  :..|..|    .
Mouse   235 YIIANLGFTDGDLLKIQFGGANVSG--FQIVDYDDSLVSKFIERWSTLEEK--EYPGAHTATIKY 295

  Fly   306 LPILIYDAVVLFASSARNV----IAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHF 366
            ...|.||||.:...:.||:    |...:..:..:.....:.||..|..|...:|.:..:.:
Mouse   296 TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGL---- 356

  Fly   367 KTENMKLDEYGQRIHFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNL-ELESAGTTQDFSEQRKV 428
             :.|:|.|:.|:||::.:.|.:...|.|..:  |:.   :.|.::.| ||.|...|...  :.|.
Mouse   357 -SGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSE---VDKMVVTLTELPSGNDTSGL--ENKT 415

  Fly   429 YTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETK 490
            ..|.|..|.||.|||::||...|.|:||||.|||.:::::...|.|:..|| |:|||   :.:||
Mouse   416 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV-GDGKYGARDADTK 479

  Fly   491 QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAV 555
            .|:|::.:|:...|.|.:..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.
Mouse   480 IWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAY 544

  Fly   556 EVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELE-----NIWNVNNSTWLMVGSIMQ 615
            |:|:.::||.:.:::....::|.|..||  .....:|..|.:     |.:.:.||.|..:|:.||
Mouse   545 EIWMCIVFAYIGVSVVLFLVSRFSPYEW--HTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQ 607

  Fly   616 QGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMR 680
            |||||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::.
Mouse   608 QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLD 672

  Fly   681 GGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN 745
            .|||..||..|....:.:.|..|:...||.|..|..||||||||.||.||:|:|:|...|..:|.
Mouse   673 SGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRK 737

  Fly   746 -CDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWW--KNHNVTCDSYHE 807
             ||..::|..:..|.||:|.|.||..||.:::::|:|||:|.|.|:|||||  |......||..:
Mouse   738 PCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSK 802

  Fly   808 VDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVT 854
            .....||:..:.|||.:|.||:.:.:::.:.||.:..:..|...::|
Mouse   803 EKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKMT 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	96/402 (24%)
		ANF_receptor	46..386	CDD:279440	90/369 (24%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	160/380 (42%)
		Lig_chan	556..828	CDD:278489	112/279 (40%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	97/408 (24%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	161/383 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846280
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740