DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GRIN3B

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_619635.1	Gene:	GRIN3B / 116444	HGNCID:	16768	Length:	1043	Species:	Homo sapiens

Alignment Length:	883	Identity:	194/883 - (21%)
Similarity:	309/883 - (34%)	Gaps:	247/883 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PTNDSFLLQQITCE-LISNGVAAIFG-PSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLN- 135
            |..|...|.:..|: |:..||||:.. |.::.....:..:|.||..|.:.. |:.||  :..|.
Human    80 PARDPASLTRGLCQALVPPGVAALLAFPEARPELLQLHFLAAATETPVLSL-LRREA--RAPLGA 141

  Fly   136 ---HQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRN 197
               ..:.::.|..|..|......:::: :.|....|      .|.|.||...:.|
Human   142 PNPFHLQLHWASPLETLLDVLVAVLQA-HAWEDVGL------ALCRTQDPGGLVA---------- 189

  Fly   198 LADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLR 262
                      ||  |.......:::||                          |:..||.::|||
Human   190 ----------LW--TSRAGRPPQLVLD--------------------------LSRRDTGDAGLR 216

  Fly   263 DIYNEDFKANITSVRLKVVDANP----------FERKKTRLTKVDQ----ILGNQTMLP------ 307
                    |.:..:...|....|          ..|.:..|..|..    :||  |.||
Human   217 --------ARLAPMAAPVGGEAPVPAAVLLGCDIARARRVLEAVPPGPHWLLG--TPLPPKALPT 271

  Fly   308 -------------------ILIYDAVVLFASSARNVIAAMQP---FHPPNRHCGSSSP------- 343
                               ..|:|.|.|.| .|....|.:||   ..|...:||...|
Human   272 AGLPPGLLALGEVARPPLEAAIHDIVQLVA-RALGSAAQVQPKRALLPAPVNCGDLQPAGPESPG 335

  Fly   344 WMLGAFIVNE----------MKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVW 398
            ..|..|:.|.          :...|:..:..|||..:::.|..|                 ...|
Human   336 RFLARFLANTSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRG-----------------APAW 383

  Fly   399 TPDNGIKKRLLNLELESAGTTQDFSEQRKVY---TVVTHYEEPYFMMKEDHEN------------ 448
            ......:...|:||...|.......:..:|:   .|||..|.|:...::..|:
Human   384 ATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVVTLLEHPFVFARDPDEDGQCPAGQLCLDP 448

  Fly   449 -----------FRG----------REKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNP-ETKQ 491
                       |..          |:...||.:||:.:|:|...||:|..:| |:|||.. ...:
Human   449 GTNDSATLDALFAALANGSAPRALRKCCYGYCIDLLERLAEDTPFDFELYLV-GDGKYGALRDGR 512

  Fly   492 WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISIL-HYKSPPEPKNQFAFLEPFAV 555
            |.|::..|:...|.:.|...:|...|..|||||.||....:.|: ..:....|..  ||:.|...
Human   513 WTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASPIG--AFMWPLHW 575

  Fly   556 EVWIYMIFAQLIMTLAFVFIARLSYREWLPP---NPAIQDPDELENIWNVNNSTWLMVGSIMQQG 617
            ..|: .:||.|.:|..|     |:..||..|   .|.           ..|.||.....|.:...
Human   576 STWL-GVFAALHLTALF-----LTVYEWRSPYGLTPR-----------GRNRSTVFSYSSALNLC 623

  Fly   618 CDIL---------PRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDK 673
            ..||         |:.|..|:|..:|..|.|::||:|||||||.:..:|....:..:.|    .|
Human   624 YAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHD----PK 684

  Fly   674 VH-------FGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGY-A 730
            :|       ||::...|...:..:|        :..|..........|...|||.:..:.... |
Human   685 LHHPAQGFRFGTVWESSAEAYIKKS--------FPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNA 741

  Fly   731 FLMETTSLTY--NIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNK 793
            |:|:.:.|.|  :|:.:|.|..:|:....:.||:.:|..|...:|||..|.:....|.:..:.:|
Human   742 FIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK 806

  Fly   794 WWKNHNVTCDS--YHEVDGDELSIIELGGVFLVLAGGV 829
            |:|  .|.|..  :...:..::||....|:|::|..|:
Human   807 WYK--MVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGL 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	73/394 (19%)
		ANF_receptor	46..386	CDD:279440	72/376 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	108/429 (25%)
		Lig_chan	556..828	CDD:278489	74/295 (25%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	19..405	CDD:107372	77/410 (19%)
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	106/424 (25%)
		Lig_chan	576..842	CDD:278489	74/296 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740