DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GRIN3A

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	992	Identity:	205/992 - (20%)
Similarity:	373/992 - (37%)	Gaps:	223/992 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMP----TNDSFLLQQITCE 87
            |:.|.:. |.:.|....|:.::.:....::..:.||.          |    ::|.|...|..|.
Human   133 DNLNRVE-GLLPYNLSLEVVMAIEAGLGDLPLLPFSS----------PSSPWSSDPFSFLQSVCH 186

  Fly    88 -LISNGVAAIFG-PSSKAAS---DIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSI------- 140
             ::..||:|:.. |.|:...   |:|:.:.:...|..:.::...|:  |..|:.|:|:
Human   187 TVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRES--QNPLHLQLSLENSLSSD 249

  Fly   141 -NVAPSLSVLSRAY-FEIIKSNYEWR-TFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYA 202
             :|..|:..::..| |.::....:|. |..|:.........|..::||.|         ||....
Human   250 ADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITA---------NLPSTQ 305

  Fly   203 D--DYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIY 265
            |  .:..:..|:.:......::..|:.::::.:.:::..|.:..|...|.|..
Human   306 DLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGD------------ 358

  Fly   266 NEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAA--M 328
                ..|:..:|.:.:........||          .|::....:.||:.|.   ||.|..|  :
Human   359 ----SQNVEELRTEGLPLGLIAHGKT----------TQSVFEHYVQDAMELV---ARAVATATMI 406

  Fly   329 QP---FHPPNRHC------GSSSPWMLGAFIVN----------EMKTISEDDVEPHFKTENMKLD 374
            ||   ..|...:|      ..:|...|..|:.|          .:|..:....|.:|...|::.|
Human   407 QPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHD 471

  Fly   375 EYGQRIHFNLEIYKPTVNEPMMVWT-----------PDNGIKKRLLNLELESAGTTQDFSEQRKV 428
            ..|          ||       :||           .|.||...      ::......|....|:
Human   472 PMG----------KP-------MWTRLGSWQGGKIVMDYGIWPE------QAQRHKTHFQHPSKL 513

  Fly   429 Y-TVVTHYEEPYFMMKE-DHEN----------------------------------FRGREKYEG 457
            : .|||..|.|:...:| |.|.                                  .:.::...|
Human   514 HLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYG 578

  Fly   458 YAVDLISKLSELMEFDYEFMIVNGNGKYNP-ETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVV 521
            |.:||:.|::|.|.||::..|| |:|||.. :...|.|::..|:...|.:.|...:|...|..|:
Human   579 YCIDLLEKIAEDMNFDFDLYIV-GDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVI 642

  Fly   522 DFTVPFMQLGISIL-HYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLP 585
            |||.||....:.|| ..:....|..  ||:.|....:|: .||..|.:|..|     |:..||..
Human   643 DFTSPFFSTSLGILVRTRDTAAPIG--AFMWPLHWTMWL-GIFVALHITAVF-----LTLYEWKS 699

  Fly   586 PNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHM---RILTGMWWFFALMMLSTYTA 647
            |............:::.:::..:....:..:...|.|  |..   |.|..:|..|.:..||||||
Human   700 PFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKP--PKCWTGRFLMNLWAIFCMFCLSTYTA 762

  Fly   648 NLAAFLTSNKWQSSIKSLQDLIEQDKVH-------FGSMRGGSTSLFFSESNDTDYQR-AWNQMK 704
            ||||.:...|....:..:.|    .|:|       ||::|         ||:..||.| ::.:|.
Human   763 NLAAVMVGEKIYEELSGIHD----PKLHHPSQGFRFGTVR---------ESSAEDYVRQSFPEMH 814

  Fly   705 DFNPSAFTSTNKEGVARVRKEKGGY-AFLMETTSLTY--NIERNCDLTQIGEQIGEKHYGLAVPL 766
            ::..........:||..::.:.... ||:|:...|.|  :|:.:|.|..:|:....:.||:.:|.
Human   815 EYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPP 879

  Fly   767 GSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCD--SYHEVDGDELSIIELGGVFLVLAGGV 829
            .|....|:|..|.|....|.:..:.:||::  .|.|.  |:...:..::.|....|:|::|..|.
Human   880 NSPLTANISELISQYKSHGFMDMLHDKWYR--VVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGF 942

  Fly   830 LIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVR-----KKPMRISSSSDKSSSRR 889
            .:.::..|.|.:       |...:.|....|::    |::|:.     .:.:..|...:|....:
Human   943 GLSILTTIGEHI-------VYRLLLPRIKNKSK----LQYWLHTSQRLHRAINTSFIEEKQQHFK 996

  Fly   890 SSGSRRSSKEKSRSKTV 906
            :....:.|....|..||
Human   997 TKRVEKRSNVGPRQLTV 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	74/423 (17%)
		ANF_receptor	46..386	CDD:279440	66/381 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	105/421 (25%)
		Lig_chan	556..828	CDD:278489	69/287 (24%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	78/431 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	69/386 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	104/419 (25%)
		Lig_chan	676..942	CDD:278489	69/288 (24%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		6/46 (13%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155807
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740