Protein Alignment GluRIIA and grin2ba

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001429729.1
• Gene: grin2ba / 110438919
• ZFINID: ZDB-GENE-090821-2
• Length: 1606
• Species: Danio rerio
• Alignment Length: 934
• Identity: 203/934 - (21%)
• Similarity: 366/934 - (39%)
• Gaps: 220/934 - (23%)

  Fly    12 IIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQA--FREVNNMKFSELRFVTIKRYMP 74
            ::::|....::..|..|:.|                 |.||  ...|..:..:|
Zfish    87 VVLVGNSSEVVMAGARDKEE-----------------FGQAALVPGVEMLTMNE----------- 123

  Fly    75 TNDSFLLQQITCELIS----NGVAAIFGPSS--KAASDIVAQIANATGIPHIEYDLKLEATRQEQ 133
            |:...:::.| |:|::    .||  :||..:  :|.:.|:..|:..|.||.:............:
Zfish   124 TDPKSIIKSI-CDLMTEHWLQGV--VFGDDTDQEAIAQILDFISAQTHIPILGVKGGSSMIMAAK 185

  Fly   134 LNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLI------------------------YETPE 174
            .::.|.....||:...:.....|:: .|:|..|:::                        :|..|
Zfish   186 DDNSMFFQFGPSIEQQASVMLNIME-EYDWYIFSIVTTYYPGYQDFVTKIRSTIENSFVGWELEE 249

  Fly   175 GLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSID 239
            .|     |:::...:.| .|::||........||...|.|   |..||           .:|:..
Zfish   250 VL-----LLDMSVDDGD-AKIQNLLKKLQSPVILLYSTKE---EANII-----------FQVAHS 294

  Fly   240 FKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQT 304
            ..|.|....|.:..|   .:|..|....:|...:.||.....|..
Zfish   295 VGLTGYGYTWIVPSL---VAGDADHIPAEFPTGMISVSYDEWDYG-------------------- 336

  Fly   305 MLPILIYDAVVLFASSARNVIAAMQPFHPPNRHC----GSSSPWMLG------AFIVNEMKTISE 359
             |...:.|.|.:.|::...::....|.......|    ...|| |.|      .:::|..
Zfish   337 -LEARVRDGVAVIATATSTMMMDRGPHTLLKSECHGAPDKKSP-MTGNNNEVLRYLMNVT----- 394

  Fly   360 DDVEPHFKTENMKLDEYGQRIHFNLEIY---KPTVNEPMMVWTPDNGIKKRLLNL----ELESAG 417
                  |:..|:...|.|.::|..|.|.   |....:.:..|  :||......::    ||.|..
Zfish   395 ------FEGRNLSFSEDGYQMHPKLVIILLDKERQWDRVGKW--ENGSLSMKYHVWPRFELYSGP 451

  Fly   418 TTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRG--------------------------REKYE 456
            ..::...    .::||..|.| |::.||.:...|                          :...:
Zfish   452 EAREDDH----LSIVTLEEAP-FVIVEDVDPLSGTCMRNTVPCRKQLKALNQTQDSAVYIKRCCK 511

  Fly   457 GYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMRRSV 520
            |:.:|::.|:::.::|.|:..:|. |||:..:.. .|:|::.:::..:|.:.|..|||.:.|..|
Zfish   512 GFCIDILKKIAKNVKFTYDLYLVT-NGKHGKKINGTWNGMVGEVVLKNAHMAVGSLTINEERSEV 575

  Fly   521 VDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREW 583
            :||:|||::.|||::..:|  ...|.   ||||||:.:|||.|....|:::...|||.     |:
Zfish   576 IDFSVPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWIMMFVMLLLVSAIAVFIF-----EY 632

  Fly   584 LPP---NPAIQDPDELEN-IWNVNNSTWLMVGSIMQQGCDIL-PRGPHMRILTGMWWFFALMMLS 643
            ..|   |..:.|..|... .:.:..:.||:.|.:......:. |||...:|:..:|.|||::.|:
Zfish   633 FSPVGYNRCLADGREAGGPSFTIGKAIWLLWGLVFNNSVPVQNPRGTTSKIMVSVWAFFAVIFLA 697

  Fly   644 TYTANLAAFLTSNKWQSSIKSLQDLIEQD------KVHFGSMRGGSTSLFFSESNDTDYQRAWNQ 702
            :||||||||:...::...:..|.|...|:      ...||::..|||.           :...|.
Zfish   698 SYTANLAAFMIQEEYVDQVSGLSDKKFQNPNDFSPPFRFGTVPNGSTE-----------RNIRNN 751

  Fly   703 MKDFNPSAFTSTNKEGVARVRKEKGGY--AFLMETTSLTYNIERN--CDLTQI--GEQIGEKHYG 761
            .:|.:........:..|..:...|.|.  ||:.:...|.|...|:  |.|..|  |:......||
Zfish   752 YRDMHSYMVKFHQRNVVEALESLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYG 816

  Fly   762 LAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYH---EVDGDELSIIELGGVFL 823
            :|:...|.::..:.::||||...||:::::..|     :|...:|   ||...:|.:..:.|||.
Zfish   817 IAIQKDSGWKRQVDLAILQLFGDGEMEELEALW-----LTGICHHEKNEVMSSQLDVDNMAGVFY 876

  Fly   824 VLAGGVLIGVILGIFE--FLWNVQ 845
            :|...:.:.:|..|.|  |.|:::
Zfish   877 MLGAAMALSLITFIAEHVFYWHMR 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	74/416 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	108/415 (26%)
		Lig_chan	555..828	CDD:459656	75/292 (26%)
grin2ba	NP_001429729.1	None