DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIA and LOC110438919

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_021328141.1	Gene:	LOC110438919 / 110438919	-ID:	-	Length:	1417	Species:	Danio rerio

Alignment Length:	800	Identity:	180/800 - (22%)
Similarity:	317/800 - (39%)	Gaps:	181/800 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 MSINVAPSLSVLSRAYFEIIKSNYEWRTFTLI------------------------YETPEGLAR 178
            |.....||:...:.....|:: .|:|..|:::                        :|..|.|
Zfish     1 MFFQFGPSIEQQASVMLNIME-EYDWYIFSIVTTYYPGYQDFVTKIRSTIENSFVGWELEEVL-- 62

  Fly   179 LQDLMNIQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQ 243
               |:::...:.| .|::||........||...|.|   |..||           .:|:....|.
Zfish    63 ---LLDMSVDDGD-AKIQNLLKKLQSPVILLYSTKE---EANII-----------FQVAHSVGLT 109

  Fly   244 GPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPI 308
            |....|.:..|   .:|..|....:|...:.||.....|..                     |..
Zfish   110 GYGYTWIVPSL---VAGDADHIPAEFPTGMISVSYDEWDYG---------------------LEA 150

  Fly   309 LIYDAVVLFASSARNVIAAMQPFHPPNRHC----GSSSPWMLG------AFIVNEMKTISEDDVE 363
            .:.|.|.:.|::...::....|.......|    ...|| |.|      .:::|..
Zfish   151 RVRDGVAVIATATSTMMMDRGPHTLLKSECHGAPDKKSP-MTGNNNEVLRYLMNVT--------- 205

  Fly   364 PHFKTENMKLDEYGQRIHFNLEIY---KPTVNEPMMVWTPDNGIKKRLLNL----ELESAGTTQD 421
              |:..|:...|.|.::|..|.|.   |....:.:..|  :||......::    ||.|....::
Zfish   206 --FEGRNLSFSEDGYQMHPKLVIILLDKERQWDRVGKW--ENGSLSMKYHVWPRFELYSGPEARE 266

  Fly   422 FSEQRKVYTVVTHYEEPYFMMKEDHENFRG--------------------------REKYEGYAV 460
            ...    .::||..|.| |::.||.:...|                          :...:|:.:
Zfish   267 DDH----LSIVTLEEAP-FVIVEDVDPLSGTCMRNTVPCRKQLKALNQTQDSAVYIKRCCKGFCI 326

  Fly   461 DLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFT 524
            |::.|:::.::|.|:..:|. |||:..:.. .|:|::.:::..:|.:.|..|||.:.|..|:||:
Zfish   327 DILKKIAKNVKFTYDLYLVT-NGKHGKKINGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFS 390

  Fly   525 VPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPP- 586
            |||::.|||::..:|  ...|.   ||||||:.:|||.|....|:::...|||.     |:..|
Zfish   391 VPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWIMMFVMLLLVSAIAVFIF-----EYFSPV 447

  Fly   587 --NPAIQDPDELEN-IWNVNNSTWLMVGSIMQQGCDIL-PRGPHMRILTGMWWFFALMMLSTYTA 647
              |..:.|..|... .:.:..:.||:.|.:......:. |||...:|:..:|.|||::.|::|||
Zfish   448 GYNRCLADGREAGGPSFTIGKAIWLLWGLVFNNSVPVQNPRGTTSKIMVSVWAFFAVIFLASYTA 512

  Fly   648 NLAAFLTSNKWQSSIKSLQDLIEQD------KVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDF 706
            |||||:...::...:..|.|...|:      ...||::..|||.           :...|..:|.
Zfish   513 NLAAFMIQEEYVDQVSGLSDKKFQNPNDFSPPFRFGTVPNGSTE-----------RNIRNNYRDM 566

  Fly   707 NPSAFTSTNKEGVARVRKEKGGY--AFLMETTSLTYNIERN--CDLTQI--GEQIGEKHYGLAVP 765
            :........:..|..:...|.|.  ||:.:...|.|...|:  |.|..|  |:......||:|:.
Zfish   567 HSYMVKFHQRNVVEALESLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQ 631

  Fly   766 LGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYH---EVDGDELSIIELGGVFLVLAG 827
            ..|.::..:.::||||...||:::::..|     :|...:|   ||...:|.:..:.|||.:|..
Zfish   632 KDSGWKRQVDLAILQLFGDGEMEELEALW-----LTGICHHEKNEVMSSQLDVDNMAGVFYMLGA 691

  Fly   828 GVLIGVILGIFE--FLWNVQ 845
            .:.:.:|..|.|  |.|:::
Zfish   692 AMALSLITFIAEHVFYWHMR 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	54/302 (18%)
		ANF_receptor	46..386	CDD:279440	50/281 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	108/415 (26%)
		Lig_chan	556..828	CDD:278489	75/291 (26%)
LOC110438919	XP_021328141.1	PBP1_iGluR_NMDA_NR2	<1..255	CDD:107373	55/312 (18%)
		PBP2_iGluR_NMDA_Nr2	267..667	CDD:270436	109/429 (25%)
		DUF4013	<389..478	CDD:315788	31/96 (32%)
		NMDAR2_C	704..1417	CDD:313729	2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740