Protein Alignment GluRIIA and grik3

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_031752773.1
• Gene: grik3 / 100498426
• XenbaseID: XB-GENE-6050069
• Length: 919
• Species: Xenopus tropicalis
• Alignment Length: 905
• Identity: 291/905 - (32%)
• Similarity: 477/905 - (52%)
• Gaps: 80/905 - (8%)

  Fly    32 ITVGAIFYENE---KEIELSFDQAFR---EVNNMKFSELRFVTIK---RYMPTNDSFLLQQITCE 87
            |.:|.||...|   .::..:.:||||   .:.|...:.|...|:.   :.:...|||...:..|:
 Frog    36 IRIGGIFEHLEGPTGQLVSAEEQAFRFSASIINRNRTLLPNTTLTYDIQRINLYDSFEANRKACD 100

  Fly    88 LISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMS--INVAPSLSVLS 150
            .::.||.||||||..::|:.|..|.||..:|||:...|     ...|:::.|  :|:.|..:.||
 Frog   101 QLALGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWK-----HHPLDNRDSFYVNLYPDYASLS 160

  Fly   151 RAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDET 215
            .|..::::. .:||:.|::|:...||.|||:|:...|..:..:|:|.|...::|.|.|.||. :.
 Frog   161 HAILDLVQF-LKWRSATVVYDDSTGLIRLQELIMAPARYNIRLKIRQLPPESEDARPLLKEM-KR 223

  Fly   216 FHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFK---ANITSVR 277
            ..|.|||.||......::|:.::...:...:.::..|.||.:...|     |.::   .|:|..|
 Frog   224 GREFRIIFDCSHTMAAQILRQAMAMGMMTEYYHYIFTTLDLYALDL-----EPYRYSGVNLTGFR 283

  Fly   278 LKVVDANPF----------ERKKTRLTKVDQIL-GNQTMLPILIYDAV----VLFASSARNVIAA 327
            :..|| ||:          ||.:........:| |..|....|.||||    |.:..:.:..:.:
 Frog   284 ILNVD-NPYVSSIVDKWSMERHQATPKPESGLLDGIMTTDAALTYDAVHIVSVCYQRAPQMTVNS 347

  Fly   328 MQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHF---KTENMKLDEYGQRIHFNLEI--Y 387
            :|        |.....|..|:..:|.:|....:.:....   ||..::.|       |:|:|  .
 Frog   348 LQ--------CHRHKAWRFGSRFMNFIKEAQWEGLTGRIVFNKTSGLRTD-------FDLDIISL 397

  Fly   388 KPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQ--RKVYTVVTHYEEPYFMMKEDHENFR 450
            |....|.:..|.|.:|     ||:...:.|...:.||.  .:...|.|..||||.|.|.......
 Frog   398 KEDGLEKVGTWNPSDG-----LNITETARGRGPNISESLTNRTLIVTTVLEEPYVMFKRSDTPLF 457

  Fly   451 GREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY--NPETKQWDGIIRKLIDHHAQIGVCDLTI 513
            |::::||:.:||:.|::|::.|||:..:|. :.||  ..|..||:|::::||||.|.:.|..|||
 Frog   458 GKDRFEGFCIDLLKKIAEILGFDYDIRLVE-DAKYGSQDEKGQWNGLVKELIDHKADLAVAPLTI 521

  Fly   514 TQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARL 578
            |.:|..|:||:.|||.||||||:.|:.....:.|:||.|.:.::|:|::.|.|.::.....|||.
 Frog   522 THVREKVIDFSKPFMTLGISILYRKANGTAPSVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARF 586

  Fly   579 SYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLS 643
            |..||...:|.....|.:||.:.:.||.|..||::||||.:::|:....||:.|:||||.|:::|
 Frog   587 SPYEWYDAHPCNPGTDVVENNFTLLNSFWFAVGALMQQGSELMPKALSTRIIGGIWWFFTLIIIS 651

  Fly   644 TYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNP 708
            :||||||||||..:.:|:|.|..||.:|.|:.:|::..|:|..||.:|:.:.:::.|..|.. .|
 Frog   652 SYTANLAAFLTVERMESAIDSADDLAKQTKIEYGAVVDGATMNFFKKSHISTFEKMWAFMSS-RP 715

  Fly   709 SAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTN 773
            ||...:|:||:.||.  ...||.|||:|::.|..:|||:|||||..|..|.||:..|:||.||..
 Frog   716 SALVKSNEEGIQRVL--SADYALLMESTAIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDR 778

  Fly   774 LSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIF 838
            :|::||||.|..|:.|||.:||::..  |......:...|.|..:||:|:|||||:::.|::.:.
 Frog   779 ISIAILQLQEADEIHKMKERWWRSGG--CPEEKNKEASALGIQNMGGIFIVLAGGLILSVVVAMA 841

  Fly   839 EFLWNVQNVAVEERVTPWQAFKAELIFAL--KFWVRKKPM-RISSSSDKSSSRRSSGSRR 895
            ||::.::..|..|:.:.......|:..:|  :..|:.||. .:...||...:..:...||
 Frog   842 EFVYKLRKTAEREQRSFCSTMADEIRLSLTCQRRVKHKPQPPVMVKSDAVINMHTFNDRR 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	105/405 (26%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	154/371 (42%)
		Lig_chan	555..828	CDD:459656	111/272 (41%)
grik3	XP_031752773.1	PBP1_iGluR_Kainate	37..417	CDD:380605	107/412 (26%)
		Periplasmic_Binding_Protein_Type_2	433..801	CDD:473866	154/371 (42%)