DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIA and grik3

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_031752773.1	Gene:	grik3 / 100498426	XenbaseID:	XB-GENE-6050069	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	905	Identity:	291/905 - (32%)
Similarity:	477/905 - (52%)	Gaps:	80/905 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENE---KEIELSFDQAFR---EVNNMKFSELRFVTIK---RYMPTNDSFLLQQITCE 87
            |.:|.||...|   .::..:.:||||   .:.|...:.|...|:.   :.:...|||...:..|:
Frog    36 IRIGGIFEHLEGPTGQLVSAEEQAFRFSASIINRNRTLLPNTTLTYDIQRINLYDSFEANRKACD 100

  Fly    88 LISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMS--INVAPSLSVLS 150
            .::.||.||||||..::|:.|..|.||..:|||:...|     ...|:::.|  :|:.|..:.||
Frog   101 QLALGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWK-----HHPLDNRDSFYVNLYPDYASLS 160

  Fly   151 RAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDET 215
            .|..::::. .:||:.|::|:...||.|||:|:...|..:..:|:|.|...::|.|.|.||. :.
Frog   161 HAILDLVQF-LKWRSATVVYDDSTGLIRLQELIMAPARYNIRLKIRQLPPESEDARPLLKEM-KR 223

  Fly   216 FHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFK---ANITSVR 277
            ..|.|||.||......::|:.::...:...:.::..|.||.:...|     |.::   .|:|..|
Frog   224 GREFRIIFDCSHTMAAQILRQAMAMGMMTEYYHYIFTTLDLYALDL-----EPYRYSGVNLTGFR 283

  Fly   278 LKVVDANPF----------ERKKTRLTKVDQIL-GNQTMLPILIYDAV----VLFASSARNVIAA 327
            :..|| ||:          ||.:........:| |..|....|.||||    |.:..:.:..:.:
Frog   284 ILNVD-NPYVSSIVDKWSMERHQATPKPESGLLDGIMTTDAALTYDAVHIVSVCYQRAPQMTVNS 347

  Fly   328 MQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHF---KTENMKLDEYGQRIHFNLEI--Y 387
            :|        |.....|..|:..:|.:|....:.:....   ||..::.|       |:|:|  .
Frog   348 LQ--------CHRHKAWRFGSRFMNFIKEAQWEGLTGRIVFNKTSGLRTD-------FDLDIISL 397

  Fly   388 KPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQ--RKVYTVVTHYEEPYFMMKEDHENFR 450
            |....|.:..|.|.:|     ||:...:.|...:.||.  .:...|.|..||||.|.|.......
Frog   398 KEDGLEKVGTWNPSDG-----LNITETARGRGPNISESLTNRTLIVTTVLEEPYVMFKRSDTPLF 457

  Fly   451 GREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY--NPETKQWDGIIRKLIDHHAQIGVCDLTI 513
            |::::||:.:||:.|::|::.|||:..:|. :.||  ..|..||:|::::||||.|.:.|..|||
Frog   458 GKDRFEGFCIDLLKKIAEILGFDYDIRLVE-DAKYGSQDEKGQWNGLVKELIDHKADLAVAPLTI 521

  Fly   514 TQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARL 578
            |.:|..|:||:.|||.||||||:.|:.....:.|:||.|.:.::|:|::.|.|.::.....|||.
Frog   522 THVREKVIDFSKPFMTLGISILYRKANGTAPSVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARF 586

  Fly   579 SYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLS 643
            |..||...:|.....|.:||.:.:.||.|..||::||||.:::|:....||:.|:||||.|:::|
Frog   587 SPYEWYDAHPCNPGTDVVENNFTLLNSFWFAVGALMQQGSELMPKALSTRIIGGIWWFFTLIIIS 651

  Fly   644 TYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNP 708
            :||||||||||..:.:|:|.|..||.:|.|:.:|::..|:|..||.:|:.:.:::.|..|.. .|
Frog   652 SYTANLAAFLTVERMESAIDSADDLAKQTKIEYGAVVDGATMNFFKKSHISTFEKMWAFMSS-RP 715

  Fly   709 SAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTN 773
            ||...:|:||:.||.  ...||.|||:|::.|..:|||:|||||..|..|.||:..|:||.||..
Frog   716 SALVKSNEEGIQRVL--SADYALLMESTAIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDR 778

  Fly   774 LSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIF 838
            :|::||||.|..|:.|||.:||::..  |......:...|.|..:||:|:|||||:::.|::.:.
Frog   779 ISIAILQLQEADEIHKMKERWWRSGG--CPEEKNKEASALGIQNMGGIFIVLAGGLILSVVVAMA 841

  Fly   839 EFLWNVQNVAVEERVTPWQAFKAELIFAL--KFWVRKKPM-RISSSSDKSSSRRSSGSRR 895
            ||::.::..|..|:.:.......|:..:|  :..|:.||. .:...||...:..:...||
Frog   842 EFVYKLRKTAEREQRSFCSTMADEIRLSLTCQRRVKHKPQPPVMVKSDAVINMHTFNDRR 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	104/404 (26%)
		ANF_receptor	46..386	CDD:279440	95/368 (26%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	154/371 (42%)
		Lig_chan	556..828	CDD:278489	111/271 (41%)
grik3	XP_031752773.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920