Protein Alignment GluRIIA and grin2d

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_031762459.1
• Gene: grin2d / 100496465
• XenbaseID: XB-GENE-1011863
• Length: 1345
• Species: Xenopus tropicalis
• Alignment Length: 922
• Identity: 204/922 - (22%)
• Similarity: 346/922 - (37%)
• Gaps: 262/922 - (28%)

  Fly    75 TNDSFLLQQITCELIS----NGVAAIFGPSSKAASDIVAQIAN----ATGIPHIEYD-------- 123
            ||...|:.|| |:::|    :||  :|...::..|  ||||.:    .|.:|.|..:
 Frog    80 TNPRSLILQI-CDVLSSLRIHGV--VFEDDTRTES--VAQILDFISAQTSMPIIGINGGSAIVLT 139

  Fly   124 --------LKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQ 180
                    |:|.|:.::||                :..||::: .|:|.:|.:|.....|   .:
 Frog   140 PKEKGSTFLQLGASTEQQL----------------QVIFEVLE-EYDWTSFAVITTLFPG---YE 184

  Fly   181 DLMNIQALNSDYVKLRNLADYADDYRILWKE--------TDE-----------TFHEQRIILDCE 226
            |.:       ||::|     ..|...|.|:.        ||:           ....|..:|.|.
 Frog   185 DFV-------DYIEL-----LTDSSFIGWENRGVLTLNLTDDPSGSKLKRQLREITAQVRLLYCS 237

  Fly   227 PKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKT 291
            .:....:.|.:.:..|.||...||:...   |.|..|...|.....:.:| |.....:...|:
 Frog   238 REEADGVFKAAREAGLTGPGYIWFMVGT---NLGGTDYMPEHLPVGLFTV-LSAGWKDDLHRR-- 296

  Fly   292 RLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKT 356
                              :.:.|.:.|..|.   |..:.|                .||    ..
 Frog   297 ------------------VQNGVAIIAKGAE---ALYKDF----------------GFI----PE 320

  Fly   357 ISEDDVEPHFKTENMKLDEY-------GQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLE-- 412
            .:.|...|:....|..|..|       |:...||.:.|  .:|..::|..         ||.|
 Frog   321 FNNDCRAPNLTHMNENLHRYFMNISWGGKDFSFNEDGY--LINPALVVIA---------LNKERS 374

  Fly   413 LESAGTTQDFSEQRKVYTVVTHY------------------EEPYFMMKEDHENFRG-------- 451
            .|..| ..:..:.|..|.|.:.|                  ||..|::.|..:...|
 Frog   375 WEVVG-IWEHGDLRMKYPVWSRYGKFLQPVDDDQHLTVATLEERPFVIVEGVDPATGTCIRDSVP 438

  Fly   452 -------------------REKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGII 496
                               ::..:|:.:|::.:||:.:.|.|:..:|. |||:..:.. .|:|:|
 Frog   439 CRKQLNRTDNHLTDPIIFVKQCCKGFCIDILKRLSKTIGFTYDLYLVT-NGKHGKKIDGVWNGMI 502

  Fly   497 RKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWI 559
            .::....|.:.:..|||.:.|..::||:|||::.|||::..:|  ...|.   |||||::..||:
 Frog   503 GEVFYQRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGTVSPS---AFLEPYSPAVWV 564

  Fly   560 YMIFAQLIMTLAFVFIARLSYREWLPP---NPAI---QDPDELENIWNVNNSTWLMVGSIMQQGC 618
            .|....|.:....|||.     |:..|   |.::   :.|...:  :.:..|.||:...:.....
 Frog   565 MMFVMCLTVVAVTVFIF-----EYFSPVGYNRSLSTGKRPGGSK--FTIGKSIWLLWALVFNNSV 622

  Fly   619 DI-LPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQ------DKVHF 676
            .: .|:|...:|:..:|.|||::.|::||||||||:...::..::..|.|...|      ..:.|
 Frog   623 PVENPKGTTSKIMVLIWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDKKFQRPHEQYPPLKF 687

  Fly   677 GSMRGGSTSLFFSESNDTD---YQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSL 738
            |::..|||.... .||..|   |...:||....:......|.|..           ||:.:...|
 Frog   688 GTVPNGSTEKNI-RSNYPDMHAYMIKYNQRHVEDALQNLKTGKLD-----------AFIYDAAVL 740

  Fly   739 TYNIERN--CDLTQI--GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN-- 797
            .|...::  |.|..|  |:......||:|:..||.::..:.:::||.....|::.::..|...
 Frog   741 NYMARKDEGCKLVTIGSGKVFATTGYGIALQKGSKWKRPIDLALLQFLGDDEIEMLERLWLSGIC 805

  Fly   798 HNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQ----- 857
            ||   |.. ||...:|.|..:.|||.:|    |:.:.|.:..|.|        |.:..|:
 Frog   806 HN---DKI-EVMSSKLDIDNMAGVFYML----LVAMGLSLLVFAW--------EHLIYWKLRHCM 854

  Fly   858 AFKAELIFALKF 869
            ....:|.|.|.|
 Frog   855 RHSGKLDFLLAF 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	73/379 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	105/437 (24%)
		Lig_chan	555..828	CDD:459656	74/294 (25%)
grin2d	XP_031762459.1	PBP1_iGluR_NMDA_NR2	38..390	CDD:380601	79/405 (20%)
		PBP2_iGluR_NMDA_Nr2	406..807	CDD:270436	101/423 (24%)
		NMDAR2_C	844..>873	CDD:463148	5/23 (22%)