DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and grik1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_004912220.1	Gene:	grik1 / 100493949	XenbaseID:	XB-GENE-957124	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	929	Identity:	294/929 - (31%)
Similarity:	472/929 - (50%)	Gaps:	103/929 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IIIGFLEGIIALGGDDRNEI-TVGAIFYENEKE----IELSFDQAFREVNNMKFSELRFVTIKRY 72
            :::.||..:.|:......:: .:|.||...|.|    .||:|..|...:|..          :..
Frog    25 LLLPFLCALAAITPQASQQVLRIGGIFETVENEPINVEELAFKFAVTNINRN----------RTL 79

  Fly    73 MPTN------------DSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLK 125
            ||..            |||...:..|:.::.||||:||||..::...|..|.||..:|||:...|
Frog    80 MPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWK 144

  Fly   126 LEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNS 190
            ..:...:.   ...||:.|..:.:|||..|:: .:|.|:|.|::||...||.|||:|:...:..:
Frog   145 HPSVDNKD---SFFINLHPDYAAISRAVLELV-LHYSWKTVTVVYEDSTGLIRLQELIKAPSRYN 205

  Fly   191 DYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLD 255
            ..:|:|.|.....|.|.|.||..:: .|..:|.||..:|..|:||..:...:...:.::|.|.:|
Frog   206 IKIKIRQLPSGNKDARTLLKEMKKS-REFYVIFDCSHETAAEILKQILSMGMMTEYYHYFFTTMD 269

  Fly   256 THNSGLRDIYNEDFK---ANITSVRLKVVDANP----------FERKKTRLTKVDQIL-GNQTML 306
            .....|     |.::   .|:|..||..:| ||          .||.:........:| |..|..
Frog   270 LFALDL-----EPYRYSGVNMTGFRLLNID-NPQVSSVVEKWSMERLQAPPKPETGLLDGMMTTD 328

  Fly   307 PILIYDAVVLFASSARN----VIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHF- 366
            ..|:||||.:.|.:.:.    .::::|        |....||..|...::.:|....|.:....
Frog   329 AALMYDAVYMVAVATQRATQMTVSSLQ--------CHRHKPWRFGPRFMSLIKEARWDGLTGRIT 385

  Fly   367 --KTENMKLDEYGQRIHFNLEIYK-----------PTVN------EPMMVWTPDNGIKKRLLNLE 412
              :|:.::.|       |:::|..           .|||      :.:.||..:.|: ....||:
Frog   386 FNRTDGLRRD-------FDMDIISLKEDGMEKAAGETVNHLNKVWKKVGVWNSNTGL-NMTDNLK 442

  Fly   413 LESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFM 477
            .:|...|...:.:..:.|.:  .|:||.|.::..:...|.:::|||.:||:.:||.::.|.||..
Frog   443 DKSTNITDSLANRTLIVTTI--LEDPYVMFRKSDKPLYGNDRFEGYCLDLLKELSNILGFTYEVR 505

  Fly   478 IVNGNGKYNPETK--QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSP 540
            :| .:|||..:..  :|:|::|:||||.|.:.|..||||.:|..|:||:.|||.||||||:.|..
Frog   506 LV-VDGKYGAQNDKGEWNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPN 569

  Fly   541 PEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNS 605
            ......|:||.|.:.::|:|::.|.|.::.....|||.:..||..|:|...|.|.:||.:.:.||
Frog   570 GTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNS 634

  Fly   606 TWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIE 670
            .|..||::||||.:::|:....||:.|:||||.|:::|:||||||||||..:.:|.|.|..||.:
Frog   635 FWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK 699

  Fly   671 QDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMET 735
            |.|:.:|::|.|||..||.:|..:.|::.|..|.....:|....|.||:.||...  .||.|||:
Frog   700 QTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVKNNDEGIQRVLTT--DYALLMES 762

  Fly   736 TSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNV 800
            ||:.|..:|||:|||||..|..|.||:..|:||.||..::::||||.|.|:|..||.|||:.:.
Frog   763 TSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG- 826

  Fly   801 TCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIF 865
             |......:...|.:..:||:|:|||.|:::.|.:.|.||::..:..:..|:...:.|...||..
Frog   827 -CPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNSDIEQCLSFNAIMEELGI 890

  Fly   866 ALKF--WVRKKPMRISSSS 882
            :||.  .::|||.....||
Frog   891 SLKHPKRLKKKPKAKGRSS 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	106/424 (25%)
		ANF_receptor	46..386	CDD:279440	95/372 (26%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	155/371 (42%)
		Lig_chan	556..828	CDD:278489	113/271 (42%)
grik1	XP_004912220.1	Periplasmic_Binding_Protein_Type_1	43..438	CDD:299141	107/431 (25%)
		ANF_receptor	61..404	CDD:279440	96/378 (25%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:304360	155/373 (42%)
		Lig_chan	585..854	CDD:278489	113/272 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010