DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and grik4

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_031761990.1	Gene:	grik4 / 100490768	XenbaseID:	XB-GENE-1011875	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	815	Identity:	245/815 - (30%)
Similarity:	407/815 - (49%)	Gaps:	82/815 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 CELISNGVAAIFGPS-SKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVL 149
            |:::..||..:.||| |.::|.|::.|.....:|||:  :..|...:.|.....::|:.||.:.:
Frog    83 CQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPHIK--VSTEEFLRFQYQRFTTLNLHPSNTDI 145

  Fly   150 SRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDE 214
            |.|...:::. :...|..||....|.|..|:.|:....::.|.:.:|.|.|..|...:|.:..|:
Frog   146 SAAVATLLRF-FNSTTACLICAKAECLLNLEKLLRQFLISKDCLSVRMLDDTWDPTPLLKEIRDD 209

  Fly   215 TFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLD----THNSGLRD------------ 263
              ....||:.........:|..:.:..:...:..:..|:|:    ...|.|.|
Frog   210 --KTSTIIVHANASMSHTILMKAAELGMVTAYYTYIFTNLEFVLQRFESPLDDRVNILGFSMFNQ 272

  Fly   264 --IYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIA 326
              .|.::|...:.....:..|.:||.              ...:...|::|||.       .:::
Frog   273 SHSYFKEFAHTLQQSWEENCDHSPFT--------------GPALSAALLFDAVY-------GIVS 316

  Fly   327 AMQPFHPPNR---------HCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHF 382
            |:|..   ||         .||||..|..|..::|.::.:..:.:..|     ::.:..|||.::
Frog   317 AVQEL---NRSQEIGVKPLSCGSSQIWQHGTSLMNYLRMVELEGLTGH-----VEFNSKGQRSNY 373

  Fly   383 NLEI--YKPTVNEPMMVWTPDNGIKKRLLNLELE--SAGTTQDFSEQRKVYTVVTHY--EEPYFM 441
            :::|  |..|..:.:..|...||     ||::..  |...:.....:..:.|.:..:  |.||.|
Frog   374 DMKIMQYTKTGFQEIGQWHVTNG-----LNMDKRYFSPNASDTLVNKTLIVTTILFFLQENPYLM 433

  Fly   442 MKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYN-PETK-QWDGIIRKLIDHHA 504
            :|.:|:...|.::|||:.||::.:|:.::.|:|:..:| .:|.|. ||.. .|.|::.:||...|
Frog   434 LKANHQELEGNDRYEGFCVDMLKELAAILRFNYKIRLV-ADGVYGVPELNGTWTGMVGELISRKA 497

  Fly   505 QIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMT 569
            .:.|..||||..|..|:||:.|||.||||||:..........|:||:||:..||::|:.|.|.::
Frog   498 DLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVS 562

  Fly   570 LAFVFIARLSYREWLPPNPAIQDP-DELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGM 633
            .....:|||:..||..|:|..|.. :.|.|.:::.||.|..||..||||..|.||....|.::|:
Frog   563 CVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGV 627

  Fly   634 WWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQR 698
            ||.|.|:::|:||||||||||..:....|:|:.||.:|..:.:|::.|||:..||..|....|||
Frog   628 WWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTTIEYGTIHGGSSMTFFQNSRYQTYQR 692

  Fly   699 AWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLA 763
            .||.|....||.|..:.:||:|||.  ...||||:|:|...|..:|||:|||:|..:..|.||:.
Frog   693 MWNYMHSKQPSVFVKSTEEGIARVL--NSNYAFLLESTMNEYYRQRNCNLTQVGGLLDTKGYGIG 755

  Fly   764 VPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGG 828
            :|:||.:|....::||||.|...|:.:|.|||.......:..|...|  |.:..:||:|:||..|
Frog   756 MPVGSAFRDEFDLAILQLQENNCLEDLKRKWWDGGKCPKEEDHRAKG--LGMENIGGIFVVLICG 818

  Fly   829 VLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAEL 863
            :::.:::.:.||||.|:| |.:..|:..|...:||
Frog   819 LIVAILIAMLEFLWTVRN-AEDSEVSVCQEMASEL 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	71/347 (20%)
		ANF_receptor	46..386	CDD:279440	66/327 (20%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	149/374 (40%)
		Lig_chan	556..828	CDD:278489	109/272 (40%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:415822	74/355 (21%)
grik4	XP_031761990.1	PBP2_iGluR_kainate_KA1	414..788	CDD:270442	149/376 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010