Protein Alignment GluRIIA and grin2b

DIOPT Version :9

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 871
• Identity: 190/871 - (21%)
• Similarity: 349/871 - (40%)
• Gaps: 216/871 - (24%)

  Fly    86 CELISN----GVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLE-------ATRQEQLNHQMS 139
            |:|:|:    ||  :||..:.  .:.:|||.:...:..:...|.:.       |.::|.   .|.
 Frog    81 CDLMSDKKVQGV--VFGDDTD--QEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEA---SMF 138

  Fly   140 INVAPSLSVLSRAYFEIIKSNYEWRTFTLI------YETPEGLAR-----------LQDLMNI-Q 186
            ....||:...:.....|:: .|:|..|:::      |:..|...|           |:::::: .
 Frog   139 FQFGPSIEQQASVMLNIME-EYDWYIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDM 202

  Fly   187 ALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFL 251
            :|:.:..|::|..              :......|:|.|..:....:.:|:....|.|....|.:
 Frog   203 SLDDNDSKIQNQL--------------KKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGYTWIV 253

  Fly   252 THLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVL 316
            ..|   .:|..|....:|...:.||.....|.:                     ||..:.|.:.:
 Frog   254 PSL---VAGDTDTVPAEFPTGLISVSYDEWDYD---------------------LPARVRDGIAI 294

  Fly   317 FASSARNVIAAMQPFHPPNRHCGS------SSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDE 375
            ..::|..:::...........|.:      ....||..:::|..           |:..|:...|
 Frog   295 ITTAASTMLSEHNSIPQSKSSCYNIQESRVYEAHMLKRYLINVT-----------FEGRNLSFSE 348

  Fly   376 YGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLE--LESAGTTQDFSEQRKVY--------- 429
            .|.::|..|.|.                    |||.:  .|..|..:|.|.:.|.|
 Frog   349 DGYQMHPKLVII--------------------LLNQQRKWERVGKYKDRSLKMKYYVWPVFELYP 393

  Fly   430 ----------TVVTHYEEPYFMMKEDHENFRG--------------------------REKYEGY 458
                      ::||..|.| |::.||.:...|                          :...:|:
 Frog   394 NSEEHKDEHLSIVTLEEAP-FVIVEDVDPLSGTCMRNTVPCRKQIRTENRTEEGGNYIKRCCKGF 457

  Fly   459 AVDLISKLSELMEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVD 522
            .:|::.|:::.::|.|:..:|. |||:..:.. .|:|:|.:::...|.:.|..|||.:.|..|||
 Frog   458 CIDILKKIAKTVKFTYDLYLVT-NGKHGKKINGTWNGMIGEVVTKRAYMAVGSLTINEERSEVVD 521

  Fly   523 FTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFI----ARLSYR 581
            |:|||::.|||::..:|  ...|.   ||||||:.:||:.|....||::...||:    :.:.|.
 Frog   522 FSVPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYN 583

  Fly   582 EWL-----PPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDIL-PRGPHMRILTGMWWFFALM 640
            ..|     |..|:          :.:..:.||:.|.:......:. |:|...:|:..:|.|||::
 Frog   584 RCLADGREPGGPS----------FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 638

  Fly   641 MLSTYTANLAAFLTSNKWQSSIKSLQDLIEQ------DKVHFGSMRGGSTSLFFSESN-DTDYQR 698
            .|::||||||||:...::...:..|.|...|      ....||::..|||     |.| ..:|..
 Frog   639 FLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGST-----ERNIRNNYLE 698

  Fly   699 AWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN--CDLTQI--GEQIGEKH 759
            ..:.|..||..:.    ::.:..::..|.. ||:.:...|.|...|:  |.|..|  |:......
 Frog   699 MHSYMVKFNQRSV----QDALLSLKTGKLD-AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTG 758

  Fly   760 YGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HNVTCDSYHEVDGDELSIIELGGVF 822
            ||:|:...|.::..:.::||||...||:::::..|...  ||    ..:||...:|.|..:.|||
 Frog   759 YGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHN----EKNEVMSSQLDIDNMAGVF 819

  Fly   823 LVLAGGVLIGVILGIFE--FLWNVQN 846
            .:||..:.:.:|..|.|  |.|.:::
 Frog   820 YMLAAAMALSLITFIMEHLFFWQLRH 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	56/352 (16%)
		ANF_receptor	46..386	CDD:279440	55/334 (16%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	111/438 (25%)
		Lig_chan	556..828	CDD:278489	76/294 (26%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	63/378 (17%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	109/424 (26%)
		NMDAR2_C	837..1449	CDD:402274	2/9 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910