Protein Alignment GluRIIA and grid2

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_031759030.1
• Gene: grid2 / 100487676
• XenbaseID: XB-GENE-955038
• Length: 1007
• Species: Xenopus tropicalis
• Alignment Length: 945
• Identity: 233/945 - (24%)
• Similarity: 413/945 - (43%)
• Gaps: 147/945 - (15%)

  Fly     7 VIYAFIIIIGFLEGIIALGGDDRNEIT-VGAIFYENEKEIELSFDQAFREVN-NMKFSELRFVTI 69
            |::|||.:..|  ..::.|....:.|. :||||.|:.|:.:..|..|..::| |....:...:|.
 Frog     3 VLHAFICMSVF--WTVSWGRTRADSIIHIGAIFDESAKKDDEVFRMAVADLNLNEDILQTEKITF 65

  Fly    70 K-RYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQ 133
            . .::..|:.|...|..|:|:|.|:.|:......|::..:..:|:|..|||:........|.:..
 Frog    66 SVTFVDGNNPFQAVQEACDLMSQGILALVSSIGCASAGSLQSLADAMHIPHLFIQRSTARTPRSG 130

  Fly   134 LNHQMSINVAP-SLSVLSRAYFE--IIK--SNYEWRTFTLIYETPEGLARLQDLMN--------- 184
            ...|.|..:.. :|||....|..  |::  :.|.|:.|.:.|:....:..:|:.::
 Frog   131 CGLQRSSGIDDYTLSVRPPVYLNDVILRVVTEYAWQKFIVFYDNNYDIRGIQEFLDRVSQQGMDV 195

  Fly   185 -IQALNSDY----------VKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSI 238
             :|.:.::.          :::..|..|.|..|             |.||...|.|.|..:...:
 Frog   196 ALQKVENNINRMITGLFATMRIEELNRYRDTLR-------------RAILVMSPTTAKAFITEVV 247

  Fly   239 DFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKV-VDANPFER--------KKTRLT 294
            :..|.....:|.:.:.:.::..::::..... ..:|.:|... |..|..:|        ..:...
 Frog   248 ETNLVAFDCHWIIINEEINDLDVQELVRRSI-GRLTIIRQTFPVPHNSSQRCFRGNHRISTSLCD 311

  Fly   295 KVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHC--GSSSPWMLGAFIVNEMK-- 355
            ..|....|..:..:.|||.|:|.|::....:...:.....:..|  .:|.||..|..::..:|
 Frog   312 PKDPFSQNMEITNMYIYDTVLLLANAFHKKLEDRKWHSMASLTCIRKNSKPWQGGRSMLETVKKG 376

  Fly   356 ---------TISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNL 411
                     ..|||...|:...|.:..: ||:.:...:        ..:..|.|..|:...|.:.
 Frog   377 GVSGLTGALDFSEDGGNPNIYFEILGTN-YGEELGRGI--------RKLGFWNPVTGLNGSLTDR 432

  Fly   412 ELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGR-EKYEGYAVDLISKLSELMEFDYE 475
            :||:       :.:..|..|.|..|||:.|:.   ||..|: :||:|:::|::..||..:.|.||
 Frog   433 KLEN-------NMRGVVLRVATVLEEPFVMVS---ENVLGKPKKYQGFSIDVLDALSSYLGFKYE 487

  Fly   476 FMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKS 539
            ..:.:.:...:|:.. .|:|:|.:|:...|.:|:..||||..|.:|||||..:|...:.:|..|:
 Frog   488 IYVASDHKYGSPQADGSWNGLIGELLLKRADMGISALTITPDRENVVDFTTRYMDYSVGVLLRKA 552

  Fly   540 PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNN 604
             .:..:.||.|.||.:.:|..:....|::.|....:      .||.| |.:|.......  .:.|
 Frog   553 -EKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP-PRLQMGSMTST--TLYN 607

  Fly   605 STWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLI 669
            |.|.:.||.:|||.::.......|::.|.||.|||:::|:||||||||||.::.:|||:|||||.
 Frog   608 SMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTISRIESSIQSLQDLS 672

  Fly   670 EQDKVHFGS---------MRGGSTSLFFSESNDTDYQRAWNQMKDFNPSA-FTSTNKEGVARVRK 724
            .|..:.:|:         :|....:.|   ..|:.|.:.|..:...|.|. ....:.||:.:|:
 Frog   673 RQTDIPYGTVFDSAVYEHVRVKGMNPF---ERDSMYSQMWRMINRSNGSENNVQESLEGIQKVK- 733

  Fly   725 EKGGYAFLMETTSLTYNI--ERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGEL 787
             .|.|||:.:...|.|..  :::|....:|..|.::.||:|:..||.||...|..||:|.:.|::
 Frog   734 -HGNYAFVWDAAVLEYIAINDQDCSFYTVGNTIADRGYGIALQHGSPYRDIFSQRILELQQNGDM 797

  Fly   788 QKMKNKWWKNHNVTCDSYHEVD----GDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVA 848
            ..:|:|||. .|..|:.:..:|    |..|.|....|||.:||.|:::...:.:.|..||
 Frog   798 DILKHKWWP-RNGQCELHSSMDTKQKGSSLDIKSFSGVFCILAAGIVLSCFIAMVETWWN----- 856

  Fly   849 VEERVTPWQAFKAELIFALKFWVRKKPMRISSSSD 883
                                   :||..|:.|..|
 Frog   857 -----------------------KKKGSRVPSKED 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	80/421 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	122/383 (32%)
		Lig_chan	555..828	CDD:459656	90/288 (31%)
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:471960	80/423 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	122/383 (32%)