DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and LOC100334689

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_017206939.1	Gene:	LOC100334689 / 100334689	-ID:	-	Length:	991	Species:	Danio rerio

Alignment Length:	896	Identity:	277/896 - (30%)
Similarity:	449/896 - (50%)	Gaps:	110/896 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIEL--SFDQAFR-EVNNMKFSELRFVTIKR 71
            |.|:::.:::....:    .:.|.:|.||.:.:..:.|  |.:.||: .|||:..:       :.
Zfish    13 AIIVVLFWIQSSFGM----PHVIRIGGIFEQTDGPVALVSSEELAFKFAVNNINRN-------RT 66

  Fly    72 YMPTN------------DSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDL 124
            .:|..            |||...:..|:.:|.||.||||||..::|:.|..|.||..:|||:...
Zfish    67 LLPNTTLTYDIQRINIYDSFEASRKACDQLSLGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRW 131

  Fly   125 KLEATRQEQLNHQMS------INVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLM 183
            |         :|.|.      .|:.|..|.||.|..::::. .:|:|.|::|:...||.|||:|:
Zfish   132 K---------HHPMDNRDTFYANLYPDYSSLSYAILDLVQF-LKWKTATVVYDDSTGLIRLQELI 186

  Fly   184 NIQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRN 248
            ...:..:..:|:|.|.....|.|.|.||...: .|.|||.||......::||.:....:...:.:
Zfish   187 MAPSRYNIRLKIRQLPMDTVDTRPLLKEMKRS-REFRIIFDCSHTMAAQILKQAQMMGMMTEYYH 250

  Fly   249 WFLTHLDTHNSGLRDIYNEDFK---ANITSVRLKVVDANP----------FERKKTRLTKVDQIL 300
            :..|.||     |..|..|.::   .|:|..|:..|| ||          .||:.........:.
Zfish   251 YIFTTLD-----LMAINLEPYRFCGVNMTGFRILNVD-NPQVASIVEKWSLERQIPPKPDSGLLE 309

  Fly   301 GNQTMLPILIYDAVVLFASSARNVIAAMQPFHPP-----NRHCGSSSPWMLGAFIVNEMKTISED 360
            |..|....|.||||.:.:.|.:         |.|     :..|....||..|...::.:|
Zfish   310 GIMTTDAALTYDAVHIVSVSYQ---------HAPQMTVNSLQCHRHKPWRFGGRFMSFIK----- 360

  Fly   361 DVEPHFKTENMKL---DEYGQRIHFNLEI--YKPTVNEPMMVWTPDNGI------KKRLLNLELE 414
              |.|:.....:|   ...|.|..|:|:|  .|....:.:..|:...|:      ::..:|:
Zfish   361 --ESHWDGLTGRLCFNRTTGLRTDFDLDIVSLKEDGLQKVGKWSASGGLNITEVPRQNGMNI--- 420

  Fly   415 SAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIV 479
                |...|.:..|.|.:  .||||.|:|:..:...|.:::||:.:||:.:|:.::.|.||..:|
Zfish   421 ----TDSLSNRSLVITTI--LEEPYVMLKKSDKALVGNDRFEGFCIDLLKELASILGFSYEIHLV 479

  Fly   480 NGNGKY--NPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPE 542
             .:|||  ..:..||:|:||:|::|.|.:.|..||||.||...:||:.||:..|||||:.|....
Zfish   480 -PDGKYGFQDDKGQWNGMIRELMEHRADLAVAPLTITFMREKAIDFSKPFLNTGISILYRKPNST 543

  Fly   543 PKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTW 607
            ....|:||.|...::|:|::.|.|.::.....|||.|..||...:|.....|.:||.:.:.||.|
Zfish   544 NSGFFSFLNPMTPDIWVYILLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSDVVENNFTLLNSFW 608

  Fly   608 LMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQD 672
            ..|||:||||.:::|:....||:.|:||||.|:::|:||||||||||..:..|.:.|..||.:|.
Zfish   609 FGVGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMDSPVDSADDLAKQT 673

  Fly   673 KVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTS 737
            |:.:|.::.|:|..||.:|..:.:::.|..|.....::|..:.::|:.||.  |..||.|||:|:
Zfish   674 KIEYGVVKDGATMSFFKKSRVSTFEKMWAFMSSRQSTSFVKSIEDGIQRVL--KSDYALLMESTT 736

  Fly   738 LTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTC 802
            :.|...|||:|||:|..|..|.||:..|.||.||..::::||.:.|.|.|..:|.|||...:...
Zfish   737 IEYVTRRNCNLTQVGGIIDSKGYGIGTPKGSPYRDKITIAILGILEDGRLHMLKEKWWSGSSCLE 801

  Fly   803 DSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERV 853
            |..:|.  ..:.|..|||:|:|||.|:::.|.:.|.||::.::..|..|:|
Zfish   802 DERYET--GPMGIQNLGGIFIVLASGLVLSVFVAIGEFIYKLRKTAEREQV 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	107/414 (26%)
		ANF_receptor	46..386	CDD:279440	101/381 (27%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	144/371 (39%)
		Lig_chan	556..828	CDD:278489	105/271 (39%)
LOC100334689	XP_017206939.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650