DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIA and grid1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001096470.1	Gene:	grid1 / 100125089	XenbaseID:	XB-GENE-990290	Length:	1009	Species:	Xenopus tropicalis

Alignment Length:	898	Identity:	224/898 - (24%)
Similarity:	395/898 - (43%)	Gaps:	150/898 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENEKEIELSFDQAFREV---NNMKFSELRFVTIKRYMPTNDSFLLQQITCELISNGV 93
            |.:||||.||..:.:..|..|..::   :::..||....:|| ::..|:.|...|..|:|::.|:
Frog    24 IHIGAIFEENAVKDDEVFQLAVSDLSLNDDILQSEKITYSIK-FIEANNPFQAVQEACDLMTQGI 87

  Fly    94 AAIFGPSSKAASDIVAQIANATGIPHI-----------------------EYDLKLEATRQEQLN 135
            .|:...:..|:::.:..:.:|..||||                       ||  .|.|....:||
Frog    88 LALVTSTGCASANALQSLTDAMHIPHIFVQRNSGGSPRTVCQFNPSPEGEEY--TLAARPPVRLN 150

  Fly   136 HQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLM----------NIQALNS 190
                       .|:.:...|:     .|:.|.:.|::...:..||..:          ::|.::.
Frog   151 -----------DVMLKLVTEL-----RWQKFIVFYDSDYDIRGLQGFLDQASRLGLDVSLQKVDR 199

  Fly   191 DY----------VKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGP 245
            :.          :|...|..|.|..|             |.||...|:..:..:..:::..|...
Frog   200 NISRVFATLFTSMKTEELNRYRDTLR-------------RAILLLSPRGAQSFISEAVETNLASK 251

  Fly   246 FRNWFLTHLDTHNSGLRDIYNEDFKANITSVR-----LKVVDAN-PFERKKTRLTKV--DQILGN 302
            ..:|...:.:.:::.:.::.:... ..||.:|     ||  |.| ...|...|:..:  |...|.
Frog   252 DSHWVYVNEEINDAEIVELVHSAL-GRITVIRQIFPSLK--DNNIRCVRNNHRIASLPCDPQEGY 313

  Fly   303 QTMLPI---LIYDAVVLFASSARNVIAAMQPFHPPNRHC--GSSSPWMLGAFIVNEMKTISEDDV 362
            ..||.:   .:||:|::.|::....:...:.....:.:|  .|:.||..|..:::   ||.:..:
Frog   314 LQMLQVSNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCMRKSTKPWNGGRSMLD---TIKKGRI 375

  Fly   363 EPHFKTENMKLDEYGQRIHFNLEIYKPTVNEP-------MMVWTPDNG----IKKRLLNLELESA 416
            ..  .|..|:..|.|...|...||...:.:|.       :..|....|    ::::.||.:|:
Frog   376 TG--LTGIMEFKEAGANPHVQFEILGTSYSETFGKDVRRLATWDSMKGFNGSLQEKPLNNDLQ-- 436

  Fly   417 GTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREK-YEGYAVDLISKLSELMEFDYEFMIVN 480
            |.|         ..|||..|||:.|:.   ||..|:.| |:|::::::.:||..:.|.|| :...
Frog   437 GLT---------LKVVTVLEEPFVMVA---ENILGQPKRYKGFSIEILDELSNRLGFKYE-IYQA 488

  Fly   481 GNGKYNPETK--QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEP 543
            .:|||..:..  .|:|:|.:||:..|.|.:..:|||..|.:|||||..::...:.|| .|.|.|.
Frog   489 PDGKYGHQLSNGSWNGMIGELINKRADIAISAITITPERENVVDFTKRYLDYSVGIL-IKKPEER 552

  Fly   544 KNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWL 608
            .|.|:...||...||. .|.|.:.:....:|:  |:..:.:....:.|......:  .::::.|:
Frog   553 INIFSLFAPFDFAVWA-CIAAVIPVVGVLIFV--LNRIQAVRAQNSSQTSQSTSS--TLHSAIWI 612

  Fly   609 MVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDK 673
            :.|:.:|||.:.......|||:.|.||.|.|::.|:||||||||||.::..:.|::.|||.:|..
Frog   613 VYGAFVQQGGESAANSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLAKQVD 677

  Fly   674 VHFGSMRGGSTSLFFSES------NDTDYQRAWNQM-KDFNPSAFTSTNKEGVARVRKEKGGYAF 731
            :.:|:::..|...:|...      .|..:...|..: |:.......|:..||:.:.:  :|.|||
Frog   678 LPYGTVKDSSVYEYFKSKGTNTLVQDRTFAELWRTIGKNNGSDNCVSSPSEGIRKAK--RGNYAF 740

  Fly   732 LMETTSLTYN--IERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKW 794
            |.:.|.:.|.  .:..|.:...|..|..|.||:|:..||.||...|..||:..:.|.|..:|.||
Frog   741 LWDVTVVEYAALTDDECSVAVTGNTISSKGYGIALQHGSPYRDIFSQRILEFQDSGRLDVLKEKW 805

  Fly   795 WKNHNVTCD--SYHEV--DGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWN 843
            |.... .||  |::..  ||..|.:....|||.:||.|:|:..::...|..||
Frog   806 WPRTG-RCDLNSHNNAQNDGKALKLHSFAGVFCILAIGLLLACLVAALELWWN 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	84/440 (19%)
		ANF_receptor	46..386	CDD:279440	73/398 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	117/381 (31%)
		Lig_chan	556..828	CDD:278489	83/284 (29%)
grid1	NP_001096470.1	PBP1_iGluR_delta_1	25..424	CDD:107387	84/438 (19%)
		ANF_receptor	39..400	CDD:279440	75/400 (19%)
		PBP2_iGluR_delta_1	437..807	CDD:270448	119/390 (31%)
		Lig_chan	565..842	CDD:278489	83/284 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000