Protein Alignment GluRIIA and grin2ca

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 1049
• Identity: 219/1049 - (20%)
• Similarity: 385/1049 - (36%)
• Gaps: 320/1049 - (30%)

  Fly    21 IIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTNDSFLLQQIT 85
            ::..|...:.||. |.:..||..::.|..:.....|||                ||...||.:|.
Zfish    44 VVFSGSAYQTEIK-GRLSRENFLDLPLEVNPITVLVNN----------------TNPRTLLTRIC 91

  Fly    86 CELISNGV-AAIFGPS--SKAASDIVAQIANATGIPHIEYD----------------LKLEATRQ 131
            ..|.:|.| ..:|..:  |:|.:.|:..|:..|.:|.:...                |:|.::.:
Zfish    92 DTLAANRVHGVVFEDNIGSEAVAQILDFISTQTAVPIVGISGGSAVVLPHKGDGSTFLQLGSSIE 156

  Fly   132 EQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLI------YETPEGLARLQDLMNIQALNS 190
            :|:|                ..|:::: .|.|.:|.::      |:|                ..
Zfish   157 QQIN----------------GMFKVME-EYNWDSFVVVTSLYPGYDT----------------YV 188

  Fly   191 DYVKLRNLADYADDYRILWKETD--------------------ETFHEQRIILDCEPKTLKELLK 235
            ||::     .:.|....||:..|                    :....|.:::.|.....:.|..
Zfish   189 DYIR-----SFIDTSYFLWELQDTLTFDMSADGMNDLRARRLLQQIDAQVLLVYCSHDEAQYLFS 248

  Fly   236 VSIDFKLQGPFRNWFLTHL----------DTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKK 290
            ::.:..|.||...||:..|          |:...||..|..:.:|.::              |.:
Zfish   249 MAREVGLVGPGYIWFIPSLAVGNPNIAPPDSFPVGLISIITDRWKMSL--------------RNR 299

  Fly   291 TRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHP-----PNRHCGSSSPWMLGAFI 350
            .|                   |.|.:       |:..::.|..     |:.|....||
Zfish   300 VR-------------------DGVAI-------VVKGVESFRKQRGFIPDGHMDCLSP------- 331

  Fly   351 VNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNG--------IKKR 407
               ::..|...:..|....:.:..::.    ||.:.|  .||..|::.|.|.|        .:..
Zfish   332 ---IRPASNGTLYRHMLNVSWENTDFS----FNSDGY--LVNPSMIIITLDRGRQWDKVGNYESG 387

  Fly   408 LLNLEL---ESAGTTQDFSEQRKVYTVVTHYEEPYFMMK--------------------EDHENF 449
            :|.:..   ...||..:.....:..||.|..|.|:.:::                    ...|..
Zfish   388 ILQMRYPVWPRYGTFLEPVSDNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPCRRQSNKTETI 452

  Fly   450 RGR-EKY-----EGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETKQ-WDGIIRKLIDHHAQIG 507
            .|. |.|     :|:.:|::.|||..::|.|:..:|. |||:....:. |:|:|.::....|.:.
Zfish   453 VGHTEPYTKLCCKGFCIDILKKLSRNIKFSYDLYLVT-NGKHGKLVRGIWNGMIGEVFYKRADMA 516

  Fly   508 VCDLTITQMRRSVVDFTVPFMQLGISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTL 570
            :..|||.:.|..::||:|||::.|||::..:|  ...|.   |||||::..||:.|....|.:..
Zfish   517 IGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWVMMFVMCLTVVA 578

  Fly   571 AFVFI----ARLSYREWL-----PPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDI-LPRGP 625
            ..||:    :.:.|...|     |..|.          :.:..|.||:.|.:......| .|:|.
Zfish   579 VTVFVFEYCSPVGYNRSLVSAKDPGGPT----------FTIGKSVWLLWGIVFNNSVPIENPKGT 633

  Fly   626 HMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQD---LIEQDK---VHFGSMRGGST 684
            ..:|:..:|.|||::.|::||||||||:...::..::..|.|   ...||:   ..||::..|||
Zfish   634 TSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQDQYPPFRFGTVPNGST 698

  Fly   685 SLFFSESN-DTDYQRAWNQMKDFNPSAFTSTNKEGVA-RVRKEKGGY--AFLMETTSLTY--NIE 743
                 |.| .::|....:.|..:        |::||. .:...|.|.  ||:.:...|.|  ..:
Zfish   699 -----ERNIRSNYPEMHSHMVKY--------NQKGVEDALNSLKTGKLDAFIYDAAVLNYMAGKD 750

  Fly   744 RNCDLTQI--GEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYH 806
            ..|.|..|  |:......||:|:...|.::..:.:::||....|:.||::..|..  .:..:...
Zfish   751 EGCKLVTIGSGKVFATTGYGIALQKESRWKRPIDLALLQFLADGDTQKLQTVWLT--GICRNEKK 813

  Fly   807 EVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLW----------------------------- 842
            ||...:|.|..:.|||.:|    |:.:.|.:..|.|
Zfish   814 EVMSSKLDIDNMAGVFYML----LVAMGLSLLVFAWEHLLYWKLRHSVRKSERLDFLLAISRGIY 874

  Fly   843 -------------NVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRISSSSDKSS------SR 888
                         |:||..|....|  ||...:::...|..|  ...|:.:|.|.::      ||
Zfish   875 SCFNGVEDTDRKGNMQNPDVTTSYT--QANMLKMLQTAKDIV--SSARVENSLDNATKTIENWSR 935

  Fly   889 RSSGSRRSS 897
            |...|.|:|
Zfish   936 RDPESGRTS 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	73/439 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	110/422 (26%)
		Lig_chan	555..828	CDD:459656	75/296 (25%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..393	CDD:380601	77/459 (17%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	110/429 (26%)
		NMDAR2_C	847..>938	CDD:463148	15/94 (16%)