DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and INA

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_116116.1	Gene:	INA / 9118	HGNCID:	6057	Length:	499	Species:	Homo sapiens

Alignment Length:	481	Identity:	140/481 - (29%)
Similarity:	222/481 - (46%)	Gaps:	97/481 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PPSTHSQTASSPLSPTRHSRVA---EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTV 93
            ||::.....|...:.|...::.   ||.:||.||||.|.:|::|..|||:|..|..|:...|..
Human    69 PPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQR- 132

  Fly    94 TRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVR 158
            ..|.:.:..:|:.||.:.|..|::.:..|::|.::...|.||.:.|:.:.::
Human   133 HAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEE------------- 184

  Fly   159 MYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSL 223
              |||..|        .|:|         |||..:|          :::..||:|:|||..::||
Human   185 --ESRGRE--------GAER---------ALKAQQR----------DVDGATLARLDLEKKVESL 220

  Fly   224 REELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYD---AK--LKQSLQELRAQYEEQMQINR 283
            .:||:|..|:|.:|:.|.....|.     ..:.::|.|   ||  |..:|:|:|||||.....|.
Human   221 LDELAFVRQVHDEEVAELLATLQA-----SSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNL 280

  Fly   284 DEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLER 348
            ...:..|:.|...|.|.|||::.:...|.||:...|.::.|....|..|..||..|..:|.:||
Human   281 QSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELE- 344

  Fly   349 QLDNDRERHGQE-------IDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGE 406
                  |||..|       |..||.:|...:.||.:.|:|||||:::|::||:|||||.|||.||
Human   345 ------ERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGE 403

  Fly   407 EAR----------LNITP-----------ATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRA 450
            |.|          ||..|           :..|:.|.|...||:.......:.:..|    :|.:
Human   404 ETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVAS----KKTS 464

  Fly   451 VVDESEDHSVADYYVSA--SAKGNVE 474
            .:.||.:..:.:..:|.  :.|.|:|
Human   465 QIGESFEEILEETVISTKKTEKSNIE 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	119/366 (33%)
		Ax_dynein_light	<283..377	CDD:287215	30/100 (30%)
		LTD	466..572	CDD:279300	4/11 (36%)
INA	NP_116116.1	Head	1..87		4/17 (24%)
		Filament_head	10..92	CDD:282575	4/22 (18%)
		Coil 1A	88..129		17/40 (43%)
		Filament	93..406	CDD:278467	119/367 (32%)
		Linker 1	130..142		2/12 (17%)
		Coil 1B	143..238		35/136 (26%)
		Linker 2	239..262		5/27 (19%)
		Coil 2	263..408		59/151 (39%)
		Tail	409..499		16/86 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..466		5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910