DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and krt8

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_956374.1	Gene:	krt8 / 797433	ZFINID:	ZDB-GENE-030411-5	Length:	520	Species:	Danio rerio

Alignment Length:	388	Identity:	120/388 - (30%)
Similarity:	192/388 - (49%)	Gaps:	71/388 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRD-TVTRETTNIKNIFEAELLETRRL 114
            |..||.:::.||:|.|::||:||.||.:|..|..:....:: |.||  :||..:|||.:...||.
Zfish   112 RTQEKEQIKTLNNRFASFIDKVRFLEQQNKMLETKWSLLQNQTATR--SNIDAMFEAYIANLRRQ 174

  Fly   115 LDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRK 179
            ||....|:.:.|.|:..:....|:.|||                 ||   :|:|.:....|
Zfish   175 LDSLGNDKMKLEADLHNMQGLVEDFKNK-----------------YE---DEINKRTECEN---- 215

  Fly   180 KLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINE-SRR 243
                              :|...:|::::..:::|:||..::||.:|::|..||..:||.| ..:
Zfish   216 ------------------EFVLIKKDVDEAYMNKVELEAKLESLTDEINFLRQIFEEEIRELQSQ 262

  Fly   244 IKQTE-YSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNS 307
            ||.|. ..|:|...:.:.||    .:.|:|||||:....:|.|.:..|:.|.:.:|       .|
Zfish   263 IKDTSVVVEMDNSRNLDMDA----IVAEVRAQYEDIANRSRAEAEMWYKSKYEEMQ-------TS 316

  Fly   308 THKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQ--------EIDLL 364
            .:|..::||||:..|..||..|..|:.....:..:..:||.|:....|| |:        .|..|
Zfish   317 ANKYGDDLRSTKTEIADLNRMIQRLQSEIDAVKGQRANLENQIAEAEER-GEMAVRDAKGRIKDL 380

  Fly   365 EKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQS 427
            |..|.|.:::|.:|::||||||::|::||:|||.|.|||.|||.||    ||....:....||
Zfish   381 EDALQRAKQDMARQIREYQDLMNVKLALDIEIATYRKLLEGEEDRL----ATGIKAINISKQS 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	113/365 (31%)
		Ax_dynein_light	<283..377	CDD:287215	28/101 (28%)
		LTD	466..572	CDD:279300
krt8	NP_956374.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Head. /evidence=ECO:0000255	2..114		1/1 (100%)
		Keratin_2_head	<87..111	CDD:292825
		Filament	114..425	CDD:278467	113/366 (31%)
		Coil 1A. /evidence=ECO:0000255	115..150		14/34 (41%)
		Linker 1. /evidence=ECO:0000255	151..166		6/16 (38%)
		Coil 1B. /evidence=ECO:0000255	168..259		29/132 (22%)
		Linker 12. /evidence=ECO:0000255	260..283		7/26 (27%)
		Coil 2. /evidence=ECO:0000255	284..422		51/145 (35%)
		RILP-like	<326..>394	CDD:304877	19/68 (28%)
		Tail. /evidence=ECO:0000255	423..520		7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910