DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and krt5

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_571231.2	Gene:	krt5 / 797351	ZFINID:	ZDB-GENE-991110-23	Length:	566	Species:	Danio rerio

Alignment Length:	424	Identity:	126/424 - (29%)
Similarity:	210/424 - (49%)	Gaps:	85/424 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GPQPPPPSTHSQTASSPLS----PT-RHSRVAEKVELQNLNDRLATYIDRVRNLETENSRL---- 82
            |..|....|.:|...:||:    |. :..|..||.:::.||:|.|::||:||.||.:|..|
Zfish   125 GVVPITAVTVNQNLLAPLNLEIDPNIQVVRTQEKEQIKTLNNRFASFIDKVRFLEQQNKVLETKW 189

  Fly    83 -TIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKK 146
             .::.|||    ||  :||..:|||.:...||.||....::.:.|.::|.:....|:.|||
Zfish   190 SLLQEQTT----TR--SNIDAMFEAYIANLRRQLDGLGNEKMKLEGELKNMQNLVEDFKNK---- 244

  Fly   147 TKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETL 211
                         ||   :|:|.:                      ..:..:|...:|:::...:
Zfish   245 -------------YE---DEINKR----------------------AAVENEFVLLKKDVDAAYM 271

  Fly   212 SRVDLENTIQSLREELSFKDQIHSQEINE-SRRIKQTE-YSEIDGRLSSEYDAKLKQSLQELRAQ 274
            ::|:||..:.||::|::|...|..:|:.| ..:||.|. ..|:|...:.:.||    .:.|:|||
Zfish   272 NKVELEAKVDSLQDEINFLRAIFEEELRELQSQIKDTSVVVEMDNSRNLDMDA----IVAEVRAQ 332

  Fly   275 YEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADL 339
            ||:....:|.|.:|.|:.|.:.:|.:|.:..       ::||:|:..|..||..|:.|:.....:
Zfish   333 YEDIANRSRAEAESWYKQKFEEMQSSAGKYG-------DDLRNTKAEIADLNRMISRLQNEIEAV 390

  Fly   340 NARIRDLERQLDNDRERHGQ--------EIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEI 396
            ..:..:||.|:....|| |:        .|..||..|.|.:::|.:|::|||:||::|::||:||
Zfish   391 KGQRANLEAQIAEAEER-GELAVKDAKLRIKDLEDALQRAKQDMARQVREYQELMNVKLALDIEI 454

  Fly   397 AAYDKLLVGEEARLNITPATNTATV---QSFSQS 427
            |.|.|||.|||:|  |....||||:   :|.|.|
Zfish   455 ATYRKLLEGEESR--IASGGNTATIHIQESSSSS 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	109/369 (30%)
		Ax_dynein_light	<283..377	CDD:287215	27/101 (27%)
		LTD	466..572	CDD:279300
krt5	NP_571231.2	Keratin_2_head	<129..153	CDD:292825	5/23 (22%)
krt5	NP_571231.2	Filament	156..467	CDD:278467	109/370 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910