DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and krt4

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_571584.2	Gene:	krt4 / 794486	ZFINID:	ZDB-GENE-000607-83	Length:	497	Species:	Danio rerio

Alignment Length:	411	Identity:	123/411 - (29%)
Similarity:	208/411 - (50%)	Gaps:	80/411 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 THSQTASSPLS----PTRHS-RVAEKVELQNLNDRLATYIDRVRNLETENSRL-----TIEVQTT 89
            |.:|:..:||:    ||..: |..||.:::.||:|.|::||:||.||.:|..|     .::.|||
Zfish    90 TVNQSLLAPLNLEIDPTIQAVRTQEKEQIKTLNNRFASFIDKVRFLEQQNKMLETKWSLLQEQTT 154

  Fly    90 RDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAE 154
                ||  :||..:|||.:...||.||....::.:.|.::|.:....|:.|||
Zfish   155 ----TR--SNIDAMFEAYISNLRRQLDGLGNEKMKLEGELKNMQGLVEDFKNK------------ 201

  Fly   155 GNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENT 219
                 ||   :|:|.:.:..|                      :|...:|:::...:::|:||..
Zfish   202 -----YE---DEINKRASVEN----------------------EFVLLKKDVDAAYMNKVELEAK 236

  Fly   220 IQSLREELSFKDQIHSQEINE-SRRIKQTE-YSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQIN 282
            :.:|::|::|...::..|:.| ..:||.|. ..|:|...:.:.|:    .:.|:|||||:....:
Zfish   237 VDALQDEINFLRAVYEAELRELQSQIKDTSVVVEMDNSRNLDMDS----IVAEVRAQYEDIANRS 297

  Fly   283 RDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLE 347
            |.|.:|.|:.|.:.:|..|.:..       ::||||:..|..||..|..|:.....:.|:..:||
Zfish   298 RAEAESWYKQKFEEMQSTAGQYG-------DDLRSTKAEIAELNRMIARLQNEIDAVKAQRANLE 355

  Fly   348 RQLDNDRERHGQ--------EIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLV 404
            .|:....|| |:        .|..||:.|.|.:::|.:|::|||:||::|::||:|||.|.|||.
Zfish   356 AQIAEAEER-GELAVKDAKLRIRELEEALQRAKQDMARQVREYQELMNVKLALDIEIATYRKLLE 419

  Fly   405 GEEARLNITPATNTATVQSFS 425
            |||:||:...|..|..||..|
Zfish   420 GEESRLSSGGAQATIHVQQTS 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	109/369 (30%)
		Ax_dynein_light	<283..377	CDD:287215	29/101 (29%)
		LTD	466..572	CDD:279300
krt4	NP_571584.2	Keratin_2_head	<82..110	CDD:292825	6/19 (32%)
		Filament	113..424	CDD:278467	109/370 (29%)
		DUF2570	304..399	CDD:305162	29/102 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910