DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and lmna

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001039148.1	Gene:	lmna / 733973	XenbaseID:	XB-GENE-920722	Length:	668	Species:	Xenopus tropicalis

Alignment Length:	599	Identity:	208/599 - (34%)
Similarity:	349/599 - (58%)	Gaps:	47/599 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 STHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETT 98
            |||     :||||||.:|:.||.:||.||||||.|||:||:||:||:.|.:.:..:.:.|:||.:
Frog    12 STH-----TPLSPTRITRLQEKEDLQELNDRLAVYIDKVRSLESENAGLRLRITESEEVVSREVS 71

  Fly    99 NIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESR 163
            .||..:||||.:.|:.||..|::|||.::::.::.||::|||.:..||..:..||:..::..|:.
Frog    72 GIKGAYEAELADARKTLDSVAKERARLQLELSKIREEHKELKARNAKKESDLLTAQARLKDLEAL 136

  Fly   164 ANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELS 228
            .|..:.....|..:::.|..::.|....:.:|.....:|:|.|:.|.|.|||.||..|:|:|||.
Frog   137 LNSKDAALTTALGEKRNLENEIRELKAHIAKLEASLADTKKQLQDEMLRRVDTENRNQTLKEELE 201

  Fly   229 FKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDK 293
            |:..|.::|:.|::|..:|...|:|.....|:::||..:||:||||:|.|:.:.::|::..|..|
Frog   202 FQKNISNEEMRETKRRHETRMVEMDNGRQREFESKLADALQDLRAQHEGQVGLYKEELEKTYNAK 266

  Fly   294 IQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHG 358
            ::..:::|.|.|:...::.||::.:|:|||:|:|.:::|::..|...|::||||.....:|:.:.
Frog   267 LENAKQSAERNSSLVGEAQEEIQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDAYARERDSNR 331

  Fly   359 QEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQS 423
            :.:...::|:..:|..|.|||.|||:|:|||::||:||.||.|||.|||.||.::|:..|.
Frog   332 RLMSDKDREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTTQ---- 392

  Fly   424 FSQSLRNSTRATPSR---RTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDPEGKFV 485
                 :.|.|...|.   ...|:|.||:|....||...|   |...|...|.|.::|:|||||:|
Frog   393 -----KRSARTVASHSGTHISSSASKRRRLEAGESGSTS---YTQHARTTGKVSVEEVDPEGKYV 449

  Fly   486 RLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKS 550
            ||.||.:|:.::|.||::|.|.|:.| ..|:|...:.::....:|:|::...|::.||:.||.|:
Frog   450 RLRNKSNEDQSLGNWQIKRQIGEETP-IVYRFPPRLTLKAGQTVTIWASGAGATNNPPTDLVWKA 513

  Fly   551 Q-KWVSADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVTAVDGNEQ---------- 604
            | .|.:.|:.||.||.|..|.||....::.:|              :...||:::
Frog   514 QSSWGTGDSIRTALLTSNNEEVAMRKLVRTVV--------------INDEDGDDEDDDDVGHHHH 564

  Fly   605 -LYHQQGDPQQSNE 617
             .:|...|.|.|.:
Frog   565 HHHHHHHDGQNSGD 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	132/354 (37%)
		Ax_dynein_light	<283..377	CDD:287215	25/93 (27%)
		LTD	466..572	CDD:279300	41/106 (39%)
lmna	NP_001039148.1	Filament	26..382	CDD:365827	132/355 (37%)
lmna	NP_001039148.1	LTD	431..538	CDD:395746	43/107 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1707
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1944
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm9565
Panther	1	1.100	-	-	LDO	PTHR45721
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160