DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and lmnb3

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001076823.1	Gene:	lmnb3 / 733537	XenbaseID:	XB-GENE-920613	Length:	582	Species:	Xenopus tropicalis

Alignment Length:	561	Identity:	196/561 - (34%)
Similarity:	329/561 - (58%)	Gaps:	24/561 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVT 94
            |.....|:..|.||.||||.||:.||.:|::||||||.||:|||:||.:.|.|.|:::...:..:
Frog     6 PSRAREHASAAPSPGSPTRISRMQEKEDLRHLNDRLAAYIERVRSLEADKSLLKIQLEEKEEVTS 70

  Fly    95 RETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRM 159
            ||.||::.::|.||.:.|:|||.||.:|||.::::.::.|:..:|:.:..||..:.:.|:..:|.
Frog    71 REVTNLRLLYETELADARKLLDQTANERARLQVELGKVREDYRQLQARNSKKETDLSLAQNLLRD 135

  Fly   160 YESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLR 224
            .||:.|........|.:.::.|.|.|.|...::..|.....:|.|.|..|.|.||||||.:|:::
Frog   136 LESKLNTKEADLATALSGKRGLEEQLQEQRAQIAGLESSLRDTTKQLHDEMLWRVDLENKMQTIK 200

  Fly   225 EELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSL 289
            |:|.|:..||.||:.|.|:...|...|||.....|:::||.::|||||..:|:|:...:::::..
Frog   201 EQLDFQRNIHEQEVKEMRKRHDTRIVEIDSGRRIEFESKLAEALQELRRDHEQQISDYKEQLERN 265

  Fly   290 YEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDR 354
            :..|::..|.|||:.|:....:.||:.:|::|:|.|::.:::.::.|:.|.|::|:|:..||...
Frog   266 FSAKLENAQLAAAKNSDYASATREEIMATKLRVDTLSSQLSQYQKQNSALEAKVRELQDMLDRAH 330

  Fly   355 ERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPA---T 416
            :.|.:::...::|:..:|:.:..||:||:.|:|:|::||:||.||.|:|.|||.||.::|:   .
Frog   331 DMHRRQMTEKDREVTEIRQTLQAQLEEYEQLLDVKLALDMEINAYRKMLEGEEQRLKLSPSPSQR 395

  Fly   417 NTATVQSFSQSLRNST-RATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDP 480
            :|.:..|.|||.|.|. :......|..:..||...||.|            ||:.|.|.:::|||
Frog   396 STVSRASTSQSSRLSRGKKRKLEETGRSVTKRAYKVVQE------------ASSTGPVSVEDIDP 448

  Fly   481 EGKFVRLFNKGSEEVAIGGWQLQRLINEKG--PSTTYKFHRSVRIEPNGVITVWSADTKASHEPP 543
            ||.:|||.|...|:.::.||.::|   :.|  |...||......::....:|:|:|...|.|.||
Frog   449 EGNYVRLLNNTEEDHSLHGWVVRR---KHGSLPEIAYKLPCRFVLKSEQRVTIWAAGAGAVHSPP 510

  Fly   544 SSLVMKSQK-WVSADNTRTILLNSEGEAVANLDRIKRIVSQ 583
            :.||.||.| |.:.| .:.|||:|.||..|. ..|.|::.:
Frog   511 TDLVWKSHKNWGTGD-IKIILLDSSGEECAE-RTIYRVIGE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	125/354 (35%)
		Ax_dynein_light	<283..377	CDD:287215	22/93 (24%)
		LTD	466..572	CDD:279300	41/108 (38%)
lmnb3	NP_001076823.1	Filament	29..385	CDD:365827	125/355 (35%)
lmnb3	NP_001076823.1	LTD	438..542	CDD:376421	40/108 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7708
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1944
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm9565
Panther	1	1.100	-	-	O	PTHR45721
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080