DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lam and LOC683313

DIOPT Version :9

Sequence 1:NP_001245892.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_001094477.1 Gene:LOC683313 / 683313 RGDID:1588056 Length:552 Species:Rattus norvegicus


Alignment Length:433 Identity:111/433 - (25%)
Similarity:206/433 - (47%) Gaps:61/433 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 GNTSTPRPPSAGPQPPPPSTHSQTASSPLS----PT-RHSRVAEKVELQNLNDRLATYIDRVRNL 75
            |....|..|..|.|   ..|.:|:..:|::    || :..|..|:.:::.||::.|::||:||.|
  Rat   112 GGAGFPVCPPGGIQ---EVTINQSLLTPMNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFL 173

  Fly    76 ETENSRLTIEVQTTRDTVTRET-TNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEEL 139
            |.:|..|..:....::..|:.. ..::.:||..:.:.|:.||:....|.|.:.:::.:....|:.
  Rat   174 EQQNKVLDTKWALLQEQGTKTVRQGLETLFEQYINDLRKELDNILGQRGRLDSELRNMQGTVEDY 238

  Fly   140 KNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRK 204
            |:|.:.:....|.||                                          .:|...:|
  Rat   239 KSKYEDEINRRTAAE------------------------------------------NEFVTLKK 261

  Fly   205 NLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAK--LKQS 267
            :::...:::|:|:....||.:|::|...::..|:::    .||..|:....||.:.:..  |...
  Rat   262 DVDAAYMNKVELQAKADSLTDEINFLRALYEAELSQ----MQTHISDTSVVLSMDNNRSLDLDSI 322

  Fly   268 LQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINEL 332
            :.|::|||||..:.:|.|.:|.|:.|.:.||..|.|..:....:.:|:......|..|.:.|:.:
  Rat   323 IAEVKAQYEEIAKRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEISEINRMIQRLRSEIDHV 387

  Fly   333 EQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIA 397
            ::..|:|.|.|.:.|::.:...:....:::.||..|.:.:::|.:.||||||||::|::||:|||
  Rat   388 KKQIANLQAAIAEAEQRGEMALKDARGKLEGLEDALQKAKQDMARLLKEYQDLMNVKLALDVEIA 452

  Fly   398 AYDKLLVGEEARLN---ITPATNTATVQSFSQSLRNSTRATPS 437
            .|..||.|||.|||   :.| .|.:.|||...|...|.....|
  Rat   453 TYRTLLEGEECRLNGEGVGP-VNISVVQSTVSSSYGSAGGASS 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamNP_001245892.1 Filament 54..409 CDD:278467 89/357 (25%)
Ax_dynein_light <283..377 CDD:287215 22/93 (24%)
LTD 466..572 CDD:279300
LOC683313NP_001094477.1 Head 1..151 11/41 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Keratin_2_head 15..148 CDD:292825 10/38 (26%)
Filament 151..464 CDD:278467 89/358 (25%)
Coil 1A 152..187 12/34 (35%)
Linker 1 188..206 3/17 (18%)
Coil 1B 207..298 20/136 (15%)
Linker 12 299..322 6/22 (27%)
Coil 2 323..461 45/137 (33%)
DUF883 377..>437 CDD:295076 14/59 (24%)
Tail 462..552 12/34 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..552
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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