DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and Krt42

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_997648.2	Gene:	Krt42 / 68239	MGIID:	1915489	Length:	452	Species:	Mus musculus

Alignment Length:	423	Identity:	123/423 - (29%)
Similarity:	191/423 - (45%)	Gaps:	90/423 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDD 117
            :||..:||||||||||:||||.||..|:.|.:::                         |.....
Mouse    93 SEKETMQNLNDRLATYLDRVRALEEANADLEVKI-------------------------REWYKK 132

  Fly   118 TARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLN 182
            .....||   |....::..|:|:||:...|.:..:....:......|::...||......|..:.
Mouse   133 QGPGPAR---DYSPYFKTIEDLRNKILAATIDNASIVLQIDNARLAADDFRTKYETELNLRMSVE 194

  Fly   183 EDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQT 247
            .|:|              ..|:.|::.||:|.|||..|:||:|||::..:.|.:|:|..|
Mouse   195 ADIN--------------GLRRVLDELTLARADLEMQIESLKEELAYLRKNHEEEMNALR----- 240

  Fly   248 EYSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRL-QEAAARTSNS 307
              .::.|.::.|.||    .|.:.|.|:|.|||:..:.||.:.:..:..|.:.| :|.|..|
Mouse   241 --GQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNT--- 300

  Fly   308 THKSIEELRSTRVRIDALNANINELE---QANADLNARIRDLERQLDNDRERHGQE-------ID 362
                 |.|:|:|..|..|..::..||   |:...:.|   .||..|.....|:|.:       |.
Mouse   301 -----EALQSSRTEITELRRSVQNLEIELQSQLSMKA---SLENSLAETEARYGAQLAQLQGLIS 357

  Fly   363 LLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQS 427
            .:|::|..||.:|.:|..|||.|:|:|..|:.|||.|.:||.||:|.|        ||  .:|.|
Mouse   358 SVEQQLCELRCDMERQNHEYQVLLDVKTRLEQEIATYRRLLEGEDAHL--------AT--QYSSS 412

  Fly   428 LRNSTRATPSRRTPSAAVKRKRAVVDESEDHSV 460
            |.:.    |||. .....::.|.:|:|.:|..|
Mouse   413 LASQ----PSRE-GMVTSRQVRTIVEEVQDGKV 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	108/369 (29%)
		Ax_dynein_light	<283..377	CDD:287215	27/104 (26%)
		LTD	466..572	CDD:279300
Krt42	NP_997648.2	Head. /evidence=ECO:0000255	4..93		123/423 (29%)
		Filament	93..404	CDD:278467	108/370 (29%)
		Coil 1A. /evidence=ECO:0000255	94..129		21/59 (36%)
		Linker 1. /evidence=ECO:0000255	130..147		3/19 (16%)
		Coil 1B. /evidence=ECO:0000255	148..239		28/104 (27%)
		FliD_C	<236..358	CDD:284583	36/139 (26%)
		Linker 12. /evidence=ECO:0000255	240..262		6/28 (21%)
		Coil 2. /evidence=ECO:0000255	263..401		48/148 (32%)
		Tail. /evidence=ECO:0000255	402..452		15/54 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000