Protein Alignment Lam and Des

DIOPT Version :10

• Sequence 1: NP_476616.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_071976.2
• Gene: Des / 64362
• RGDID: 620686
• Length: 469
• Species: Rattus norvegicus
• Alignment Length: 472
• Identity: 135/472 - (28%)
• Similarity: 229/472 - (48%)
• Gaps: 76/472 - (16%)

  Fly     5 SRRAGTA----TPQPGNTSTPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRL 65
            ||.:|.|    :.:.....|.|.||.|.......:.:...:.....||.:   ||||||.||||.
  Rat    57 SRTSGGAGGLGSLRASRLGTTRAPSYGAGELLDFSLADAVNQEFLATRTN---EKVELQELNDRF 118

  Fly    66 ATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIK 130
            |.||::||.||.:|:.|..||...:.   ||.|.:..::|.|:.|.||.::.....|||.:::..
  Rat   119 ANYIEKVRFLEQQNAALAAEVNRLKG---REPTRVAELYEEEMRELRRQVEVLTNQRARVDVERD 180

  Fly   131 RLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERL 195
            .|.::.:.||.||.::.:....||.|:..:
  Rat   181 NLIDDLQRLKAKLQEEIQLREEAENNLAAF----------------------------------- 210

  Fly   196 RKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEY 260
                   |.:::..||:|:|||..|:||.||::|..::|.:||.|.:...|.:..:::..:|.
  Rat   211 -------RADVDAATLARIDLERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSK-- 266

  Fly   261 DAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDAL 325
             ..|..:|:::|||||.....|..|.:..|:.|:..|.:||.:.:::..::.:|:...|.:|.:.
  Rat   267 -PDLTAALRDIRAQYETIAAKNISEAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSY 330

  Fly   326 NANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKV 390
            ...|:.|:..|..|..::|:||.:..::...:...|..||:|:..|::||.:.|:|||||:::|:
  Rat   331 TCEIDALKGTNDSLMRQMRELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKM 395

  Fly   391 SLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVK--------- 446
            :||:|||.|.|||.|||:|:|:       .:|:|  |..|....:|.:|......|
  Rat   396 ALDVEIATYRKLLEGEESRINL-------PIQTF--SALNFRETSPEQRGSEVHTKKTVMIKTIE 451

  Fly   447 -RKRAVVDES--EDHSV 460
             |...||.|:  :.|.|
  Rat   452 TRDGEVVSEATQQQHEV 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_476616.1	Filament	54..409	CDD:459643	109/354 (31%)
		LTD	467..572	CDD:460003
Des	NP_071976.2	Head	2..108		11/53 (21%)
		Filament_head	9..105	CDD:461414	10/47 (21%)
		Filament	106..414	CDD:459643	109/358 (30%)
		Coil 1A	109..140		18/30 (60%)
		Linker 1	141..150		3/11 (27%)
		Coil 1B	151..251		33/141 (23%)
		Linker 12	252..267		2/17 (12%)
		Interaction with NEB. /evidence=ECO:0000250|UniProtKB:P17661	267..414		50/146 (34%)
		Coil 2A	268..286		7/17 (41%)
		Linker 2	287..294		2/6 (33%)
		Coil 2B	295..411		38/115 (33%)
		Tail	412..469		16/66 (24%)
		Interaction with CRYAB. /evidence=ECO:0000250|UniProtKB:P17661	437..452		1/14 (7%)