DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lam and Lmna

DIOPT Version :10

Sequence 1:NP_476616.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_001002016.2 Gene:Lmna / 60374 RGDID:620456 Length:665 Species:Rattus norvegicus


Alignment Length:596 Identity:219/596 - (36%)
Similarity:356/596 - (59%) Gaps:43/596 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 SQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIK 101
            :|.:|:||||||.:|:.||.:||.||||||.||||||:|||||:.|.:.:..:.:.|:||.:.||
  Rat    14 AQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIK 78

  Fly   102 NIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANE 166
            ..:||||.:.|:.||..|::|||.::::.::.||.:|||.:..||..:...|:..::..|:..|.
  Rat    79 AAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLLAAQARLKDLEALLNS 143

  Fly   167 LNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKD 231
            .....:.|.::::.|..:|::...::.:|.....|.:|.|:.|.|.|||.||.:|:|:|||.|:.
  Rat   144 KEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQK 208

  Fly   232 QIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQR 296
            .|:|:|:.|::|..:|...|||.....|::::|..:|||||||:|:|::..:.|::..|..|:..
  Rat   209 NIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDN 273

  Fly   297 LQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEI 361
            .:::|.|.||....:.|||:.:|:|||:|:|.:::|::..|...|::||||..|..:|:...:.:
  Rat   274 ARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLL 338

  Fly   362 DLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQ 426
            ...|:|:..:|..|.|||.|||:|:|||::||:||.||.|||.|||.||.::|:..       ||
  Rat   339 AEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPT-------SQ 396

  Fly   427 SLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDPEGKFVRLFNKG 491
            ..|....:..|:.....:|.:||. ::.||..|  .:...|...|.|.::|:|.|||||||.||.
  Rat   397 RSRGRASSHSSQSQGGGSVTKKRK-LESSESRS--SFSQHARTSGRVAVEEVDEEGKFVRLRNKS 458

  Fly   492 SEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQK-WVS 555
            :|:.::|.||::|. |...|..||:|.....::...|:|:|::...|:|.||:.||.|:|. |..
  Rat   459 NEDQSMGNWQIRRQ-NGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSPPTDLVWKAQNTWGC 522

  Fly   556 ADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVTAV--------DGNEQLYHQQ--- 609
            ..:.||.|:|:.||.||    ::::|            ||:|.|        ||:|.|:|.:   
  Rat   523 GSSLRTALINATGEEVA----MRKLV------------RSLTMVEDNDDEEEDGDELLHHHRGSH 571

  Fly   610 ----GDPQQSN 616
                |||.:.|
  Rat   572 CSSSGDPAEYN 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamNP_476616.1 Filament 54..409 CDD:459643 139/354 (39%)
LTD 467..572 CDD:460003 42/105 (40%)
LmnaNP_001002016.2 Interaction with MLIP. /evidence=ECO:0000250|UniProtKB:P02545 1..130 54/115 (47%)
Head 1..33 10/18 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 8/12 (67%)
Filament 30..386 CDD:459643 139/355 (39%)
Coil 1A 34..70 20/35 (57%)
Linker 1 71..80 4/8 (50%)
Coil 1B 81..218 44/136 (32%)
Linker 2 219..242 6/22 (27%)
Coil 2 243..383 57/139 (41%)
Tail 384..665 72/226 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 384..442 17/67 (25%)
Nuclear localization signal. /evidence=ECO:0000255 417..422 2/5 (40%)
LTD 434..541 CDD:460003 44/111 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..577 5/24 (21%)

Return to query results.
Submit another query.