DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and zgc:172323

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001107899.1	Gene:	zgc:172323 / 564165	ZFINID:	ZDB-GENE-080204-113	Length:	847	Species:	Danio rerio

Alignment Length:	468	Identity:	118/468 - (25%)
Similarity:	207/468 - (44%)	Gaps:	105/468 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKSRRAGTATPQPGNTSTPRPP-----------SAGPQPPPPSTHSQTASSPLSPTRHSRVAEKV 56
            |.||..|..|.   :||..:|.           |.|    .|......|::.......:|.:||.
Zfish    54 SNSRAVGRRTI---STSRSQPHLNGVGMGAICLSGG----GPGADLDQAAAENREFLSTRTSEKQ 111

  Fly    57 ELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDD---- 117
            |:..||||||.||::||:||.:|..|..|::..::...: .|.::.::|.:|.|..||.|.
Zfish   112 EMILLNDRLAAYIEKVRSLEQQNKLLETEIEVLQNRFLK-PTGLRLLYEEQLKELMRLADQMRVQ 175

  Fly   118 -----TARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANAD 177
                 .|:|....:::|.::                                     ||.:|...
Zfish   176 RDIAIAAKDAMAGQLEIIKV-------------------------------------KYEEALEM 203

  Fly   178 RKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESR 242
            |||...|:              |..|.:::..|.:|:.||..:::|..||.|..::|.|||.|..
Zfish   204 RKKAELDI--------------EAFRPDVDAATSARIALEKQLENLEVELEFLRRVHKQEIEELM 254

  Fly   243 RIKQTEYSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAAR 303
            :       :|....:|..||    .|..:|::::.||::....|..|:.|.|::|...|
Zfish   255 K-------QIYAAHASAMDAYSLPDLSNALKQIQHQYDDIAAKNLQEMDSWYKNKFDDL------ 306

  Fly   304 TSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQE-------I 361
             :|.|.|.::::|..|..|.:...:|...|:....:|.:...||.|:.:.::::.:|       |
Zfish   307 -NNKTSKHVDQVRHVREGIASAKKDIQNKERDMDSMNTKNEALEAQIRDTQDKYRKELEDLQARI 370

  Fly   362 DLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARL-NITPATNTATVQSFS 425
            :.|:.||...::.....|:|||||:::|:||::||..|.||:.||::|| ::..:..|.|:.|.|
Zfish   371 EALQLELKSSKQRTALLLREYQDLLNVKMSLEIEITTYRKLIEGEDSRLTSMVQSMQTMTLMSGS 435

  Fly   426 QSLRNSTRATPSR 438
            .|:........:|
Zfish   436 TSVHTVAAGAANR 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	97/374 (26%)
		Ax_dynein_light	<283..377	CDD:287215	22/100 (22%)
		LTD	466..572	CDD:279300
zgc:172323	NP_001107899.1	Filament_head	7..107	CDD:282575	12/59 (20%)
		Filament	108..418	CDD:278467	97/375 (26%)
		DUF4200	123..248	CDD:290574	37/176 (21%)
		BBP1_C	229..378	CDD:291921	40/162 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910