DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and Krt35

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_058576.2	Gene:	Krt35 / 53617	MGIID:	1858899	Length:	455	Species:	Mus musculus

Alignment Length:	413	Identity:	111/413 - (26%)
Similarity:	188/413 - (45%)	Gaps:	96/413 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDT 118
            ||..:|:||||||:|:::||.||.||:.                           ||:|
Mouse    97 EKETMQSLNDRLASYLEKVRQLEQENAS---------------------------LESR------ 128

  Fly   119 ARDRARAEI-----DIKRLWEENEELKNKLDKKTKECTTAEGNVRMY------ESRANELNNKYN 172
            .|:....::     |.:..:...|||:    |||. |:.|| |.|:.      :..|::...||.
Mouse   129 IREWCEQQVPYMCPDYQSYFRTMEELQ----KKTL-CSKAE-NARLVVQIDNAKLAADDFRTKYE 187

  Fly   173 QANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQE 237
            ...:.|:.:..|:|              ..|:.|:..||.:.|||..::||:|||....:.|.:|
Mouse   188 TEVSLRQLVEADIN--------------GLRRILDDLTLCKADLEAQVESLKEELLCLKKNHEEE 238

  Fly   238 INESRRIKQTEYSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQ 298
            :|..|       .::..||:.|.||    .|.:.|.|:|.|||..::.||.:.:..|:.:.:.|.
Mouse   239 VNSLR-------CQLGDRLNVEVDAAPPVDLNRVLDEMRCQYETLVENNRRDAEDWYDTQTEELN 296

  Fly   299 EAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNAR--IRD-LERQLDNDRERHGQE 360
            :....:|       |:|:|.:..|..|...:|.||   .:|.|:  :|| |:..|.....|:..:
Mouse   297 QQVVSSS-------EQLQSCQSDIIELRRTVNSLE---IELQAQQSMRDALDSTLAETEGRYSSQ 351

  Fly   361 -------IDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITP-ATN 417
                   |..:|.:|..:|.::.:|.:|||.|:|::..|:.||..|..||..|:::|...| |.:
Mouse   352 LAQMQCMIGNVESQLGEIRADLERQNQEYQVLLDVRARLECEINTYRGLLESEDSKLPCNPCAPD 416

  Fly   418 TATVQSFSQSLRNSTRATPSRRT 440
            .::.:|....|...:.:|.:.||
Mouse   417 YSSSKSCLPCLPAVSCSTGAART 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	103/379 (27%)
		Ax_dynein_light	<283..377	CDD:287215	23/103 (22%)
		LTD	466..572	CDD:279300
Krt35	NP_058576.2	Head. /evidence=ECO:0000255	1..97		111/413 (27%)
		Filament	96..407	CDD:278467	103/379 (27%)
		Coil 1A. /evidence=ECO:0000255	98..132		19/66 (29%)
		Linker 1. /evidence=ECO:0000255	133..143		0/9 (0%)
		Coil 1B. /evidence=ECO:0000255	144..244		33/126 (26%)
		MIT_CorA-like	<192..>334	CDD:294313	46/172 (27%)
		Linker 12. /evidence=ECO:0000255	245..260		5/14 (36%)
		Coil 2. /evidence=ECO:0000255	261..404		43/152 (28%)
		DUF5082	305..408	CDD:293493	31/105 (30%)
		Tail. /evidence=ECO:0000255	405..455		8/35 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910