DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lam and LMNB1

DIOPT Version :9

Sequence 1:NP_001245892.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_005564.1 Gene:LMNB1 / 4001 HGNCID:6637 Length:586 Species:Homo sapiens


Alignment Length:606 Identity:222/606 - (36%)
Similarity:357/606 - (58%) Gaps:23/606 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 TSTPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRL 82
            |:||.||..|.:...|:|       ||||||.||:.||.||:.||||||.|||:||:||||||.|
Human     3 TATPVPPRMGSRAGGPTT-------PLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSAL 60

  Fly    83 TIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKT 147
            .::|....:...||.|.:|.::|.||.:.||.||||||:||:.:|::.:...|:::|.....||.
Human    61 QLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKE 125

  Fly   148 KECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLS 212
            .:...|:..:|.||:..|..:.....|..|:|.|..||.:...::.:|.......:|.|..|||.
Human   126 SDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLL 190

  Fly   213 RVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEE 277
            :|||||..|||.|:|.|:..::.:||||:||..:|...|:|.....||:.||.|:|.|:|.|::.
Human   191 KVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDA 255

  Fly   278 QMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNAR 342
            |:::.::|::..|..|::..:.::...:::.:.:.|||..:|:||::|::.::.|::.:.....|
Human   256 QVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLER 320

  Fly   343 IRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEE 407
            |::||..|..:::...:.:...|:|:..:|::|.|||.:|:.|:|:|::||:||:||.|||.|||
Human   321 IQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEE 385

  Fly   408 ARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGN 472
            .||.::|:.::....|         ||:.||...:...||||..|:|||..|......||||.||
Human   386 ERLKLSPSPSSRVTVS---------RASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGN 441

  Fly   473 VEIKEIDPEGKFVRLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTK 537
            |.|:|||.:|||:||.|...::..:|||::.|.|.:  .|.:||:.....::....:|:|:|:..
Human   442 VCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGD--TSVSYKYTSRYVLKAGQTVTIWAANAG 504

  Fly   538 ASHEPPSSLVMKSQ-KWVSADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVTAVDG 601
            .:..||:.|:.|:| .|.:.::.:.||.||:||.||.    :..|.:.|.............|..
Human   505 VTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQ----RSTVFKTTIPEEEEEEEEAAGVVV 565

  Fly   602 NEQLYHQQGDPQQSNEKCAIM 622
            .|:|:||||.|:.||..||||
Human   566 EEELFHQQGTPRASNRSCAIM 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamNP_001245892.1 Filament 54..409 CDD:278467 131/354 (37%)
Ax_dynein_light <283..377 CDD:287215 20/93 (22%)
LTD 466..572 CDD:279300 40/106 (38%)
LMNB1NP_005564.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31 16/34 (47%)
Head 2..34 17/37 (46%)
Filament 31..387 CDD:278467 131/355 (37%)
Coil 1A 35..69 21/33 (64%)
Linker 1 70..81 4/10 (40%)
Coil 1B 82..215 46/132 (35%)
Linker 2 216..243 11/26 (42%)
Coil 2 244..386 44/141 (31%)
Tail 387..586 73/213 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..432 16/52 (31%)
Nuclear localization signal. /evidence=ECO:0000255 415..420 4/4 (100%)
LTD 439..543 CDD:279300 38/109 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 270 1.000 Domainoid score I1835
eggNOG 1 0.900 - - E1_KOG0977
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 398 1.000 Inparanoid score I1952
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48052
OrthoDB 1 1.010 - - D204815at33208
OrthoFinder 1 1.000 - - FOG0001052
OrthoInspector 1 1.000 - - mtm8670
orthoMCL 1 0.900 - - OOG6_103212
Panther 1 1.100 - - LDO PTHR45721
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X632
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.840

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