| Sequence 1: | NP_001245892.1 | Gene: | Lam / 33782 | FlyBaseID: | FBgn0002525 | Length: | 622 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_733821.1 | Gene: | LMNA / 4000 | HGNCID: | 6636 | Length: | 664 | Species: | Homo sapiens |
| Alignment Length: | 594 | Identity: | 220/594 - (37%) |
|---|---|---|---|
| Similarity: | 357/594 - (60%) | Gaps: | 41/594 - (6%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 37 SQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIK 101
Fly 102 NIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANE 166
Fly 167 LNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKD 231
Fly 232 QIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQR 296
Fly 297 LQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEI 361
Fly 362 DLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNTATVQSFSQ 426
Fly 427 SLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKEIDPEGKFVRLFNKG 491
Fly 492 SEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWSADTKASHEPPSSLVMKSQK-WVS 555
Fly 556 ADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVTAV------DGNEQLYH------- 607
Fly 608 QQGDPQQSN 616 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Lam | NP_001245892.1 | Filament | 54..409 | CDD:278467 | 138/354 (39%) |
| Ax_dynein_light | <283..377 | CDD:287215 | 29/93 (31%) | ||
| LTD | 466..572 | CDD:279300 | 44/106 (42%) | ||
| LMNA | NP_733821.1 | Interaction with MLIP. /evidence=ECO:0000269|PubMed:21498514 | 1..130 | 54/115 (47%) | |
| Head | 1..33 | 10/18 (56%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..25 | 6/10 (60%) | |||
| Filament | 30..386 | CDD:365827 | 138/355 (39%) | ||
| Coil 1A | 34..70 | 20/35 (57%) | |||
| Linker 1 | 71..80 | 4/8 (50%) | |||
| Coil 1B | 81..218 | 43/136 (32%) | |||
| Linker 2 | 219..242 | 6/22 (27%) | |||
| Coil 2 | 243..383 | 57/139 (41%) | |||
| Necessary and sufficient for the interaction with IFFO1. /evidence=ECO:0000269|PubMed:31548606 | 259..331 | 24/71 (34%) | |||
| Tail | 384..664 | 74/224 (33%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 384..442 | 17/67 (25%) | |||
| Nuclear localization signal. /evidence=ECO:0000255 | 417..422 | 2/6 (33%) | |||
| LTD | 434..541 | CDD:395746 | 46/111 (41%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 552..576 | 5/23 (22%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 598..619 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 270 | 1.000 | Domainoid score | I1835 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG0977 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 398 | 1.000 | Inparanoid score | I1952 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG48052 | |
| OrthoDB | 1 | 1.010 | - | - | D204815at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001052 | |
| OrthoInspector | 1 | 1.000 | - | - | mtm8670 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_103212 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR45721 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X632 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 13 | 12.840 | |||||