DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and krt18b

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_956862.1	Gene:	krt18b / 393540	ZFINID:	ZDB-GENE-040426-1508	Length:	405	Species:	Danio rerio

Alignment Length:	416	Identity:	112/416 - (26%)
Similarity:	191/416 - (45%)	Gaps:	58/416 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSKSRRAGTATPQPGNTSTP---RPPSAGPQPPPPSTHSQTASSPLSPTRHSRVA---EKVELQ 59
            :||.|..:..:.|:.|..|:.   :..|||       ..|....|.|:.:..|...   ||.::|
Zfish    36 ISSASAMSYRSAPRSGGISSSTAFKVSSAG-------MGSGAGGSLLASSGSSGGMLGNEKGQMQ 93

  Fly    60 NLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRAR 124
            |||||||.|:|.||.||.||.:|..:::...:....||.:... :.|.|.:.||.:.|...|.||
Zfish    94 NLNDRLAAYLDTVRRLEQENGKLEQQIREALEKGGPETRDYSK-YNAILDDLRRKVFDATVDNAR 157

  Fly   125 AEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEAL 189
            ..:.|                         .|.|:   ..::...|:....|.|:.:..|
Zfish   158 LVLQI-------------------------DNARL---AVDDFRVKFENEMAIRQSVEGD----- 189

  Fly   190 KELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDG 254
              :..|:|..:||       .:.|:::|..|:||:|||.|..:.|..|::|.|  .|...|.:..
Zfish   190 --IAGLKKVIDET-------NIGRLNVEGEIESLKEELLFLKKNHENEVDELR--SQISQSGVQV 243

  Fly   255 RLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTR 319
            .:.:.....:.|.::::||.||:|...|.:|::..:|.:|..:|...|:.:.:...:..|....|
Zfish   244 DVDAPKGQDMSQVMEDMRANYEKQALKNAEELKMWHETQIADVQVQVAQNTEALQGAQMECNDLR 308

  Fly   320 VRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQD 384
            .:|..|...:...:...|.|...:|:.|.:.:.:.|:....|..||.||.:||..:|:|.:||:.
Zfish   309 RQIQTLEIELASQQNLKASLEDTLRNTEIRSNGEMEKLNNIIIQLEAELAQLRANITEQGQEYEA 373

  Fly   385 LMDIKVSLDLEIAAYDKLLVGEEARL 410
            |:::|:.|:.||..|.|||.||:.:|
Zfish   374 LLNMKMKLEAEINTYKKLLDGEDFKL 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	98/354 (28%)
		Ax_dynein_light	<283..377	CDD:287215	21/93 (23%)
		LTD	466..572	CDD:279300
krt18b	NP_956862.1	Filament	87..398	CDD:278467	98/355 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000