Protein Alignment Lam and KRT39

DIOPT Version :10

• Sequence 1: NP_476616.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_998821.3
• Gene: KRT39 / 390792
• HGNCID: 32971
• Length: 491
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 119/465 - (25%)
• Similarity: 189/465 - (40%)
• Gaps: 119/465 - (25%)

  Fly    54 EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDT 118
            ||..:|.||:|||.|:.:||.||.||:.|..::|
Human    96 EKETMQILNERLANYLQKVRMLERENAELESKIQ------------------------------- 129

  Fly   119 ARDRARAEI-----DIKRLWEENEELKNKLDKKTKECTTAEGNVRMYES------RANELNNKYN 172
              :.:..|:     |....:...|||:.|:     .||.|| |.|:...      .|::|..||.
Human   130 --EESNKELPVLCPDYLSYYTTIEELQQKI-----LCTKAE-NSRLVSQIDNTKLTADDLRAKYE 186

  Fly   173 QANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQE 237
            ...:.|:.:..|.| .||::             |...||.:.|||..:|||:|||......|.:|
Human   187 AEVSLRQLVESDAN-GLKQI-------------LNVLTLGKADLEAQVQSLKEELLCLKNNHKEE 237

  Fly   238 INESRRIKQTEYSE-IDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAA 301
            ||.    .|.:..| :|..:::...|.|.|.|||:|.|||..|:.||.:::..:..:|:.|.:..
Human   238 INS----LQCQLGERLDIEVTAAPSADLNQVLQEMRCQYEPIMETNRKDVEQWFNTQIEELNQQV 298

  Fly   302 ARTSNS---THKSIEELRSTRVRIDALNANINELEQANADLNA--RIRDLERQLDNDRERH---- 357
            ..:|..   ..|.|.|||          .::|.||   .:|.|  |:||.:..:..:.|..
Human   299 VTSSQQQQCCQKEIIELR----------RSVNTLE---VELQAQHRMRDSQECILTETEARYTAL 350

  Fly   358 ----GQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNITPATNT 418
                ...||.||.:|..:|..:.:|.:||:.|:|:|..|:.||..|..||...:.:....|
Human   351 LTQIQSLIDNLEAQLAEIRCALERQNQEYEILLDVKSRLECEITTYRSLLESSDGKRPCYP---- 411

  Fly   419 ATVQSFSQSLRNSTRATPSRRT--PSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEI------ 475
                       .:|:..||..|  .|.|::........|...|:.::..:......:.:
Human   412 -----------RATKCEPSPWTSCKSGAIESTAPACTSSSPCSLKEHCSACGPLSRILVKICTIT 465

  Fly   476 KEIDPEGKFV 485
            ||| .:||.:
Human   466 KEI-KDGKVI 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_476616.1	Filament	54..409	CDD:459643	105/379 (28%)
		LTD	467..572	CDD:460003	5/25 (20%)
KRT39	NP_998821.3	Head	1..96		119/465 (26%)
		Filament	95..404	CDD:459643	105/377 (28%)
		Coil 1A	97..131		16/66 (24%)
		Linker 1	132..142		1/9 (11%)
		Coil 1B	143..243		35/123 (28%)
		Linker 12	244..259		2/14 (14%)
		Coil 2	260..403		47/155 (30%)
		Tail	404..491		14/87 (16%)