DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and KRT33B

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_002270.1	Gene:	KRT33B / 3884	HGNCID:	6451	Length:	404	Species:	Homo sapiens

Alignment Length:	421	Identity:	111/421 - (26%)
Similarity:	181/421 - (42%)	Gaps:	102/421 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PPSTHSQTASSPLS-PTRHSRV----------AEKVELQNLNDRLATYIDRVRNLETENSRLTIE 85
            |||.|..|.....: |...|..          :||..:|.||||||:|:::||.||.:|:.
Human    23 PPSCHGYTLPGACNIPANVSNCNWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAE---- 83

  Fly    86 VQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDI-----KRLWEENEELKNKLDK 145
                                         |::..|:|::.:..:     :..::..|||:.|:
Human    84 -----------------------------LENLIRERSQQQEPLLCPSYQSYFKTIEELQQKI-- 117

  Fly   146 KTKECTTAEGNVRMY------ESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRK 204
               .|:.:| |.|:.      :..|::...||....:.|:.:..|:|              ..|:
Human   118 ---LCSKSE-NARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDIN--------------SLRR 164

  Fly   205 NLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDA----KLK 265
            .|::.||.|.|||..::||:|||....|.|.||:|..|       .::..||:.|.||    .|.
Human   165 ILDELTLCRSDLEAQMESLKEELLSLKQNHEQEVNTLR-------CQLGDRLNVEVDAAPAVDLN 222

  Fly   266 QSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANIN 330
            |.|.|.|.|||..::.||.|::..:..:.:.|.:....:|       |:|:|.:..|..|...:|
Human   223 QVLNETRNQYEALVETNRREVEQWFATQTEELNKQVVSSS-------EQLQSYQAEIIELRRTVN 280

  Fly   331 ELE-QANADLNARIRDLERQLDNDRERHGQE-------IDLLEKELIRLREEMTQQLKEYQDLMD 387
            .|| :..|..|.|. .||..|.....|:..:       |..:|.:|..:|.::.:|.:|||.|:|
Human   281 ALEIELQAQHNLRY-SLENTLTESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLD 344

  Fly   388 IKVSLDLEIAAYDKLLVGEEARLNITPATNT 418
            ::..|:.||..|..||..|:.:|...|...|
Human   345 VRARLECEINTYRSLLESEDCKLPSNPCATT 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	101/377 (27%)
		Ax_dynein_light	<283..377	CDD:287215	23/101 (23%)
		LTD	466..572	CDD:279300
KRT33B	NP_002270.1	Head	1..56		7/32 (22%)
		Filament	55..366	CDD:306535	101/378 (27%)
		Coil 1A	57..91		16/66 (24%)
		Linker 1	92..102		0/9 (0%)
		Coil 1B	103..203		33/126 (26%)
		Linker 12	204..219		5/14 (36%)
		Coil 2	220..363		44/150 (29%)
		Tail	364..404		3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910