DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and KRT19

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_002267.2	Gene:	KRT19 / 3880	HGNCID:	6436	Length:	400	Species:	Homo sapiens

Alignment Length:	380	Identity:	103/380 - (27%)
Similarity:	171/380 - (45%)	Gaps:	89/380 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDT 118
            ||:.:||||||||:|:|:||.||..|..|.:::   ||...::...                  .
Human    80 EKLTMQNLNDRLASYLDKVRALEAANGELEVKI---RDWYQKQGPG------------------P 123

  Fly   119 ARDRARAEIDIKRLWE-------ENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANA 176
            :||.:.....|:.|.:       ||..:..::|           |.|:   .|::...|:....|
Human   124 SRDYSHYYTTIQDLRDKILGATIENSRIVLQID-----------NARL---AADDFRTKFETEQA 174

  Fly   177 DRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINES 241
            .|..:..|:|              ..|:.|::.||:|.|||..|:.|:|||::..:.|.:||:..
Human   175 LRMSVEADIN--------------GLRRVLDELTLARTDLEMQIEGLKEELAYLKKNHEEEISTL 225

  Fly   242 RRIKQTEYSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRL-QEAA 301
            |       .::.|::|.|.|:    .|.:.|.::|:|||...:.||.:.::.:..:.:.| :|.|
Human   226 R-------GQVGGQVSVEVDSAPGTDLAKILSDMRSQYEVMAEQNRKDAEAWFTSRTEELNREVA 283

  Fly   302 ARTSNSTHKSIEELRSTRVRIDALNANINELE---QANADLNARIRDLERQLDNDRERHGQE--- 360
            ..|        |:|:.:|..:..|...:..||   |:...:.|.:.|   .|.....|.|.:
Human   284 GHT--------EQLQMSRSEVTDLRRTLQGLEIELQSQLSMKAALED---TLAETEARFGAQLAH 337

  Fly   361 ----IDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLN 411
                |..:|.:|..:|.:..:|.:|||.|||||..|:.|||.|..||.|:|...|
Human   338 IQALISGIEAQLGDVRADSERQNQEYQRLMDIKSRLEQEIATYRSLLEGQEDHYN 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	102/376 (27%)
		Ax_dynein_light	<283..377	CDD:287215	21/104 (20%)
		LTD	466..572	CDD:279300
KRT19	NP_002267.2	Head	1..79
		Filament	79..390	CDD:278467	102/376 (27%)
		Coil 1A	80..115		19/37 (51%)
		Linker 1	116..133		2/34 (6%)
		Coil 1B	134..225		29/118 (25%)
		Linker 12	226..248		6/28 (21%)
		Necessary for interaction with PNN. /evidence=ECO:0000269\|PubMed:10809736	244..390		46/156 (29%)
		Coil 2	249..387		43/148 (29%)
		Rod-like helical tail	388..400		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910