DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lam and KRT18

DIOPT Version :10

Sequence 1:NP_476616.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_000215.1 Gene:KRT18 / 3875 HGNCID:6430 Length:430 Species:Homo sapiens


Alignment Length:423 Identity:114/423 - (26%)
Similarity:194/423 - (45%) Gaps:91/423 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDT 118
            ||..:|:||||||:|:||||:|||||.||..:::...:....:..:..:.|        ::::| 
Human    80 EKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYF--------KIIED- 135

  Fly   119 ARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNE 183
                .||:|....:  :|..:..::|           |.|:   .|::...||....|.|:.:..
Human   136 ----LRAQIFANTV--DNARIVLQID-----------NARL---AADDFRVKYETELAMRQSVEN 180

  Fly   184 DLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTE 248
            |::       .|||..::|       .::|:.||..|::|:|||.|..:.|.:|      :|..:
Human   181 DIH-------GLRKVIDDT-------NITRLQLETEIEALKEELLFMKKNHEEE------VKGLQ 225

  Fly   249 YSEIDGRLSSEYDAKLKQSL----QELRAQYEEQMQINRDEIQSLYEDKI---------QRLQEA 300
            .......|:.|.||...|.|    .::||||:|..:.||:|:...:..:|         |..:..
Human   226 AQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVVTTQSAEVG 290

  Fly   301 AARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLE 365
            ||.|      ::.|||.|   :.:|..:::.:....|.|...:|::|.:.....|:....:..||
Human   291 AAET------TLTELRRT---VQSLEIDLDSMRNLKASLENSLREVEARYALQMEQLNGILLHLE 346

  Fly   366 KELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLV-GEEARLN--ITPATNTATVQSFSQS 427
            .||.:.|.|..:|.:||:.|::|||.|:.|||.|.:||. ||:..|.  :..:.:..|:|.    
Human   347 SELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDSSNSMQTIQK---- 407

  Fly   428 LRNSTRATPSRRTPSAAVKRKRAVVDESEDHSV 460
                   |.:||....      .||.|:.|..|
Human   408 -------TTTRRIVDG------KVVSETNDTKV 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamNP_476616.1 Filament 54..409 CDD:459643 103/368 (28%)
LTD 467..572 CDD:460003
KRT18NP_000215.1 Head 2..79
Necessary for interaction with PNN. /evidence=ECO:0000269|PubMed:10809736 70..373 94/350 (27%)
Interaction with TRADD. /evidence=ECO:0000269|PubMed:11684708 77..128 21/47 (45%)
Filament 79..391 CDD:459643 103/368 (28%)
Coil 1A 80..115 21/34 (62%)
Linker 1 116..132 1/23 (4%)
Coil 1B 133..224 30/131 (23%)
Linker 12 225..248 6/22 (27%)
Interaction with DNAJB6. /evidence=ECO:0000269|PubMed:10954706 243..391 47/156 (30%)
Coil 2 249..387 43/146 (29%)
Tail 388..430 12/57 (21%)
Blue background indicates that the domain is not in the aligned region.

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