DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and KRT13

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_705694.3	Gene:	KRT13 / 3860	HGNCID:	6415	Length:	458	Species:	Homo sapiens

Alignment Length:	402	Identity:	110/402 - (27%)
Similarity:	187/402 - (46%)	Gaps:	68/402 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDT 118
            ||:.:||||||||:|:::||.||..|:.|.:::   ||...:::.
Human   104 EKITMQNLNDRLASYLEKVRALEEANADLEVKI---RDWHLKQSP-------------------- 145

  Fly   119 ARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNE 183
                |..|.|....::..|||::|:...|.|.......:......|::...||....|.|:.:..
Human   146 ----ASPERDYSPYYKTIEELRDKILTATIENNRVILEIDNARLAADDFRLKYENELALRQSVEA 206

  Fly   184 DLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTE 248
            |:|              ..|:.|::.|||:.|||..|:||.|||::..:.|.:|:.|..
Human   207 DIN--------------GLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFS------ 251

  Fly   249 YSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRL-QEAAARTS--N 306
             :::.|:::.|.||    .|.:.|.|:|.|||...:.||.:.:..:..|...| :|.:..|:  .
Human   252 -NQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQ 315

  Fly   307 STHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRL 371
            ::...|.|||.|   :..|...:.......|.|...:.:.|.:.....::....|..:|.:|..|
Human   316 TSKTEITELRRT---LQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSEL 377

  Fly   372 REEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARL--------NITPATNTATVQSFSQSL 428
            |.||..|.:||:.|:|||..|:.|||.|..||.|::|::        :::|.:.:.|..| |.|:
Human   378 RSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFPSSAGSVSPRSTSVTTTS-SASV 441

  Fly   429 RNSTRATPSRRT 440
            ..::.|: .|||
Human   442 TTTSNAS-GRRT 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	100/361 (28%)
		Ax_dynein_light	<283..377	CDD:287215	21/96 (22%)
		LTD	466..572	CDD:279300
KRT13	NP_705694.3	Head	1..103
		Filament	103..415	CDD:306535	100/361 (28%)
		Coil 1A	104..139		18/37 (49%)
		Linker 1	140..158		3/41 (7%)
		Coil 1B	159..250		29/104 (28%)
		Linker 12	251..273		5/28 (18%)
		Coil 2	274..412		42/140 (30%)
		Tail	413..458		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..458		9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910