DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and KRT12

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_000214.1	Gene:	KRT12 / 3859	HGNCID:	6414	Length:	494	Species:	Homo sapiens

Alignment Length:	456	Identity:	112/456 - (24%)
Similarity:	196/456 - (42%)	Gaps:	116/456 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AEKVELQNLNDRLATYIDRVRNLETENSRLTIEVQ---TTRDTVTRETTNIKNIFEAELLETRRL 114
            :||..:||||||||:|:|:||.||..|:.|..:::   .||.|.|.:.
Human   124 SEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRGTGTADA----------------- 171

  Fly   115 LDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMY------ESRANELNNKYNQ 173
                      ::.|..:.:...|:|:||:      .:.:.||.::.      ...|.:...||..
Human   172 ----------SQSDYSKYYPLIEDLRNKI------ISASIGNAQLLLQIDNARLAAEDFRMKYEN 220

  Fly   174 ANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEI 238
            ..|.|:.:..|:|              ..|:.|::.||:|.|||..|:||.|||::..:.|..|:
Human   221 ELALRQGVEADIN--------------GLRRVLDELTLTRTDLEMQIESLNEELAYMKKNHEDEL 271

  Fly   239 NESRRIKQTEYSEIDGRLSSEYDA----KLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQE 299
             :|.|:..      .|.:|.|.||    .|.:.|.::|||||...:.||.:.::.:.:|...|::
Human   272 -QSFRVGG------PGEVSVEMDAAPGVDLTRLLNDMRAQYETIAEQNRKDAEAWFIEKSGELRK 329

  Fly   300 AAARTSNSTHKSIEELRSTRVRIDALNANI-----------NELEQANADLNARIRDLERQLDND 353
            ..:..:.....|..|:...|.....|...:           :.|.:|..|..|::..:::.:.|
Human   330 EISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISN- 393

  Fly   354 RERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGE------EARLNI 412
                      ||.:|:::|.:..:|..::|.|:::|..|:|||..|.:||.||      |..|.:
Human   394 ----------LEAQLLQVRADAERQNVDHQRLLNVKARLELEIETYRRLLDGEAQGDGLEESLFV 448

  Fly   413 TPATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIKE 477
            |.:             ::..::|.|.:.|:...|.| .||.|..:..|....|.       ||:|
Human   449 TDS-------------KSQAQSTDSSKDPTKTRKIK-TVVQEMVNGEVVSSQVQ-------EIEE 492

  Fly   478 I 478
            :
Human   493 L 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	97/384 (25%)
		Ax_dynein_light	<283..377	CDD:287215	16/104 (15%)
		LTD	466..572	CDD:279300	3/13 (23%)
KRT12	NP_000214.1	Head	1..124		112/456 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Filament	124..436	CDD:278467	94/376 (25%)
		Coil 1A	125..160		18/34 (53%)
		Linker 1	164..182		4/44 (9%)
		Coil 1B	183..274		29/111 (26%)
		Linker 12	275..297		7/27 (26%)
		Coil 2	298..435		34/147 (23%)
		Tail	436..494		17/79 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..468		5/34 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910