DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lam and KRT9

DIOPT Version :9

Sequence 1:NP_001245892.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_000217.2 Gene:KRT9 / 3857 HGNCID:6447 Length:623 Species:Homo sapiens


Alignment Length:386 Identity:88/386 - (22%)
Similarity:162/386 - (41%) Gaps:112/386 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDT 118
            ||..:|.||.|||:|:|:|:.||                                          
Human   153 EKSTMQELNSRLASYLDKVQALE------------------------------------------ 175

  Fly   119 ARDRARAEIDIKRLWEENEELKNKL----DKKTKECTTAEGNVRMYESRANELNNKYNQANADRK 179
                           |.|.:|:||:    |||..  ...:.|...|.:..::|.::.........
Human   176 ---------------EANNDLENKIQDWYDKKGP--AAIQKNYSPYYNTIDDLKDQIVDLTVGNN 223

  Fly   180 KLNEDLNEALKELERLRKQFE--------------ETRKNLEQETLSRVDLENTIQSLREELSFK 230
            |...|::.....|:..|.:||              ..|:.|:..|:.:.|||...::|:|||...
Human   224 KTLLDIDNTRMTLDDFRIKFEMEQNLRQGVDADINGLRQVLDNLTMEKSDLEMQYETLQEELMAL 288

  Fly   231 DQIHSQEINESRRIKQTEYSEIDGRLSSEYDAK--------LKQSLQELRAQYEEQMQINRDEIQ 287
            .:.|.:|:           |::.|:.|.:.:.:        |.::|.::|.:||:.:..||.:|:
Human   289 KKNHKEEM-----------SQLTGQNSGDVNVEINVAPGKDLTKTLNDMRQEYEQLIAKNRKDIE 342

  Fly   288 SLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELE-QANADLNARIRDLERQLD 351
            :.||.:|.:::       :....|.:|::|:...:..|...:.||| :..:.|:.:.. ||:.|:
Human   343 NQYETQITQIE-------HEVSSSGQEVQSSAKEVTQLRHGVQELEIELQSQLSKKAA-LEKSLE 399

  Fly   352 NDRERH-GQ------EIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVG 405
            :.:.|: ||      :|..||.::..:|:|:..|.:||..|:.||:.|:.||..|..||.|
Human   400 DTKNRYCGQLQMIQEQISNLEAQITDVRQEIECQNQEYSLLLSIKMRLEKEIETYHNLLEG 460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamNP_001245892.1 Filament 54..409 CDD:278467 88/386 (23%)
Ax_dynein_light <283..377 CDD:287215 24/101 (24%)
LTD 466..572 CDD:279300
KRT9NP_000217.2 Head 1..152
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Filament 152..464 CDD:365827 88/386 (23%)
Coil 1A 153..188 18/91 (20%)
Linker 1 189..207 5/19 (26%)
Coil 1B 208..299 20/101 (20%)
Linker 12 300..322 3/21 (14%)
Coil 2 323..461 42/146 (29%)
Tail 462..623
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 462..496
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..623
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.