DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and KRT6A

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_005545.1	Gene:	KRT6A / 3853	HGNCID:	6443	Length:	564	Species:	Homo sapiens

Alignment Length:	419	Identity:	113/419 - (26%)
Similarity:	206/419 - (49%)	Gaps:	73/419 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GPQPP--PPS-----THSQTASSPLS----PT-RHSRVAEKVELQNLNDRLATYIDRVRNLETEN 79
            ||..|  ||.     |.:|:..:||:    || :..|..|:.:::.||::.|::||:||.||.:|
Human   124 GPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQN 188

  Fly    80 SRLTIEVQTTRDTVTRE------TTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEE 138
                 :|..|:.|:.:|      ..|::.:||..:...||.||....:|.|.:.:::.:.:..|:
Human   189 -----KVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVED 248

  Fly   139 LKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETR 203
            .|||.:.:..:.|.||                                          .:|...:
Human   249 FKNKYEDEINKRTAAE------------------------------------------NEFVTLK 271

  Fly   204 KNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAK--LKQ 266
            |:::...:::|:|:....:|.:|::|...::..|:::    .||..|:....||.:.:..  |..
Human   272 KDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQ----MQTHISDTSVVLSMDNNRNLDLDS 332

  Fly   267 SLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINE 331
            .:.|::|||||..|.:|.|.:|.|:.|.:.||..|.|..:....:.:|:......|..|.:.|:.
Human   333 IIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDH 397

  Fly   332 LEQANADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEI 396
            :::..|:|.|.|.|.|::.:...:....:::.||..|.:.::::.:.|||||:||::|::||:||
Human   398 VKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEI 462

  Fly   397 AAYDKLLVGEEARLN--ITPATNTATVQS 423
            |.|.|||.|||.|||  .....|.:.|||
Human   463 ATYRKLLEGEECRLNGEGVGQVNISVVQS 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	94/362 (26%)
		Ax_dynein_light	<283..377	CDD:287215	22/93 (24%)
		LTD	466..572	CDD:279300
KRT6A	NP_005545.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Head	2..162		12/37 (32%)
		Keratin_2_head	<59..159	CDD:318448	11/34 (32%)
		Filament	162..475	CDD:306535	94/363 (26%)
		Coil 1A	163..198		14/39 (36%)
		Linker 1	199..217		4/17 (24%)
		Coil 1B	218..309		21/136 (15%)
		Linker 12	310..333		6/22 (27%)
		Coil 2	334..472		46/137 (34%)
		Tail	473..564		8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910