Protein Alignment Lam and KRT26

DIOPT Version :10

• Sequence 1: NP_476616.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_853517.2
• Gene: KRT26 / 353288
• HGNCID: 30840
• Length: 468
• Species: Homo sapiens
• Alignment Length: 449
• Identity: 106/449 - (23%)
• Similarity: 192/449 - (42%)
• Gaps: 77/449 - (17%)

  Fly    49 HSRVA--EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLET 111
            ||.::  |||.:||||||||:|:|.|..||..|:.|              ...||..:|
Human    76 HSLLSGNEKVTMQNLNDRLASYLDHVHALEEANADL--------------EQKIKGWYE------ 120

  Fly   112 RRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTA----EGNVRMYESRANELNNKYN 172
             :....::|:.   :.|..|.:...|:||.::...| .|..:    ..|.|:   .|::...||.
Human   121 -KCEPGSSREH---DHDYSRYFSVIEDLKRQIISAT-ICNASIVLQNDNARL---TADDFRLKYE 177

  Fly   173 QANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQE 237
            ...|....:..|.:              ..|:.|::.||...|||...::|.|||::..:.|.:|
Human   178 NELALHHSVEADTS--------------GLRRVLDELTLCTTDLEIQCETLSEELTYLKKSHEEE 228

  Fly   238 INESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAA 302
            :..   ::.|....::..:::.....|...|..:||:||:..:.||.:.::.:.::...||:..:
Human   229 MEV---LQYTAGGNVNVEMNATPGVDLTVLLNNMRAEYEDLAEQNRKDAEAWFNERSATLQQQIS 290

  Fly   303 RTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNARIRDLERQLDNDRERHGQEIDLLEKE 367
            ....:...:..||...:..:..|...:..|..........:.:.|....|..::...:|.::|::
Human   291 DHEGAATAARNELTELKRNLQTLEIELQSLMAVKHSYECSLAETEGNYCNQLQQIQDQIGVMEEQ 355

  Fly   368 LIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLNIT--PATNTATVQSFSQSLRN 430
            |.::|.|...|..||:.|:|:|:.|:.||..|..||.|||.:...|  .:.....|.|.:|: ::
Human   356 LQQIRTETEGQKLEYEQLLDVKIFLEKEIDIYCNLLDGEERKSKSTCYKSKGYRPVNSGNQA-KD 419

  Fly   431 STRATPSRRTPSAAVKRKRAVVDESED---------HSVADYYVSASAKGNVEIKEIDP 480
            ||..|        .||   .||:|.:.         |||.:   .:|...|:.:::..|
Human   420 STEET--------IVK---TVVEELDQIGNLLSLRVHSVEE---KSSKISNITVEQRVP 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_476616.1	Filament	54..409	CDD:459643	86/358 (24%)
		LTD	467..572	CDD:460003	3/14 (21%)
KRT26	NP_853517.2	Head. /evidence=ECO:0000255	1..82		2/5 (40%)
		Filament	82..395	CDD:459643	84/357 (24%)
		Coil 1A. /evidence=ECO:0000255	83..118		20/48 (42%)
		Linker 1. /evidence=ECO:0000255	119..140		4/30 (13%)
		Coil 1B. /evidence=ECO:0000255	141..232		25/111 (23%)
		Linker 12. /evidence=ECO:0000255	233..255		2/21 (10%)
		Coil 2. /evidence=ECO:0000255	256..394		32/137 (23%)
		Tail. /evidence=ECO:0000255	395..465		19/85 (22%)