Protein Alignment Lam and KRT27

DIOPT Version :10

• Sequence 1: NP_476616.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_853515.2
• Gene: KRT27 / 342574
• HGNCID: 30841
• Length: 459
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 122/552 - (22%)
• Similarity: 220/552 - (39%)
• Gaps: 156/552 - (28%)

  Fly     2 SSKSRRAGTATPQPGNTSTPRPPSAGP---------QPPPPSTHS-------------------Q 38
            ||.|||.|:.    |.|.:.|..|.|.         .|...|..|                   .
Human     6 SSTSRRLGSC----GGTGSVRLSSGGAGFGAGNTCGVPGIGSGFSCAFGGSSSAGGYGGGLGGGS 66

  Fly    39 TASSPLSPTRHSRVA--EKVELQNLNDRLATYIDRVRNLETENSRLTIEVQTTRDTVTRETTNIK 101
            .:.:..:...|..::  |||.:||||||||:|::.||.||..|:.|              ...||
Human    67 ASCAAFTGNEHGLLSGNEKVTMQNLNDRLASYLENVRALEEANADL--------------EQKIK 117

  Fly   102 NIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKTKECTTAEGNVRMYESR--- 163
            ..:|.....:.|.||.          |..|.:...:||||::    ...||:..:|.:....
Human   118 GWYEKFGPGSCRGLDH----------DYSRYFPIIDELKNQI----ISATTSNAHVVLQNDNARL 168

  Fly   164 -ANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREEL 227
             |::...|:....|..:.:..|:|              ..|:.|::.||.|.|||..:::|.|||
Human   169 TADDFRLKFENELALHQSVEADIN--------------GLRRVLDELTLCRTDLEIQLETLSEEL 219

  Fly   228 SFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYED 292
            ::..:.|.:|:   :.::......::..:::.....|...|..:||:||...:.||.:.::.:.:
Human   220 AYLKKNHEEEM---KALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNE 281

  Fly   293 KI----QRLQEAAARTSNSTHKSIE---ELRSTRVRIDALNANINELE----QANADLNARIRDL 346
            |.    |::.:.|..|:::.::.||   .|::..:.:.:|.|..:.||    :..::..|::..:
Human   282 KSASLQQQISDDAGATTSARNELIEMKRTLQTLEIELQSLLATKHSLECSLTETESNYCAQLAQI 346

  Fly   347 ERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEEARLN 411
            :.|           |..||::|.::|.|...|..||:.|:||||.|:.||..|..|:.||:...:
Human   347 QAQ-----------IGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCLLIDGEDGSCS 400

  Fly   412 ITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYVSASAKGNVEIK 476
                             ::.....|..:|..::   |..:|                   ...::
Human   401 -----------------KSKGYGGPGNQTKDSS---KTTIV-------------------KTVVE 426

  Fly   477 EIDPEGKFV------------RLFNKGSEEVA 496
            ||||.||.:            ::.||..:.|:
Human   427 EIDPRGKVLSSRVHTVEEKSTKVNNKNEQRVS 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_476616.1	Filament	54..409	CDD:459643	94/369 (25%)
		LTD	467..572	CDD:460003	9/42 (21%)
KRT27	NP_853515.2	Head. /evidence=ECO:0000255	1..83		15/80 (19%)
		Filament	83..396	CDD:459643	93/368 (25%)
		Coil 1A. /evidence=ECO:0000255	84..119		20/48 (42%)
		Linker 1. /evidence=ECO:0000255	120..141		6/30 (20%)
		Coil 1B. /evidence=ECO:0000255	142..233		26/111 (23%)
		Linker 12. /evidence=ECO:0000255	234..256		1/21 (5%)
		Coil 2. /evidence=ECO:0000255	257..395		39/148 (26%)
		Tail. /evidence=ECO:0000255	396..459		13/102 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..459		3/23 (13%)