DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lam and Krt4

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_006242457.1	Gene:	Krt4 / 315323	RGDID:	1359272	Length:	528	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	104/409 - (25%)
Similarity:	203/409 - (49%)	Gaps:	67/409 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GNTSTPRPPSAGPQPPPPSTHSQTASSPLS-----PTRHSRVAEKVELQNLNDRLATYIDRVRNL 75
            |....|..|:.|.|   ..|.:|:..:||.     ..:..|.||:.:::.||::.|::||:||.|
  Rat   106 GGPGFPVCPAGGIQ---EVTINQSLLTPLQVEIDPEIQKIRTAEREQIKTLNNKFASFIDKVRFL 167

  Fly    76 ETENSRL-----TIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEE 135
            |.:|..|     .::.|||    |....|:...||..:...|:.||..:.|:.|.:.::|.:.:.
  Rat   168 EQQNKVLETKWNLLQQQTT----TTSPRNLDPFFETYINALRKNLDTLSNDKGRLQSELKLMQDS 228

  Fly   136 NEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFE 200
            .|:.|.|.:::..:.|.||.:                                          |.
  Rat   229 VEDFKTKYEEEINKRTAAEND------------------------------------------FV 251

  Fly   201 ETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLK 265
            ..:|:::...:.:|:||..::||::|::|...::..|:::    .||..|:....||.:.:..|.
  Rat   252 VLKKDVDAAYMIKVELEAKMESLKDEINFMRVLYEAELSQ----MQTHVSDTSVVLSMDNNRNLD 312

  Fly   266 QS--LQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNAN 328
            ..  :.|:||||||..:.::.|::|.|:.|:|:||.:|.:..:|...:..|:......|..:.:.
  Rat   313 LDGIIAEVRAQYEEIARKSKAEVESWYQIKVQQLQMSADQHGDSLKSTKNEISELNRMIQRIRSE 377

  Fly   329 INELEQANADLNARIRDLERQLDND-RERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSL 392
            |..:::.:..|.|.:.|.|::.:.. ::.:.:..| ||..|.:.:|::.:.:::||:||::|::|
  Rat   378 IENIKKQSQTLQASVADAEQRGELALKDAYTKRAD-LETALQKAKEDLARLMRDYQELMNVKLAL 441

  Fly   393 DLEIAAYDKLLVGEEARLN 411
            |:|||.|.|||.|||.|::
  Rat   442 DVEIATYRKLLEGEECRMS 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	92/362 (25%)
		Ax_dynein_light	<283..377	CDD:287215	21/94 (22%)
		LTD	466..572	CDD:279300
Krt4	XP_006242457.1	Keratin_2_head	14..142	CDD:292825	9/38 (24%)
Krt4	XP_006242457.1	Filament	146..458	CDD:278467	92/362 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910