Protein Alignment Lam and lmnb2

DIOPT Version :9

• Sequence 1: NP_001245892.1
• Gene: Lam / 33782
• FlyBaseID: FBgn0002525
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_571077.2
• Gene: lmnb2 / 30196
• ZFINID: ZDB-GENE-990630-13
• Length: 583
• Species: Danio rerio
• Alignment Length: 620
• Identity: 235/620 - (37%)
• Similarity: 358/620 - (57%)
• Gaps: 54/620 - (8%)

  Fly    18 TSTPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNLETENSRL 82
            |:||...||             |.:||||.|.||:.||.||:.||||||.||||||.||.||.||
Zfish     3 TATPSRASA-------------AQTPLSPARISRLQEKEELRALNDRLAVYIDRVRALELENDRL 54

  Fly    83 TIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELKNKLDKKT 147
            ..:|....:..|||.:.||:::||||.:.||:||:|||:||:.:|::.::..|.||:.....||.
Zfish    55 QFKVSEKEEVTTREVSGIKSLYEAELADARRVLDETARERAKLQIELGKVNSELEEVTRNYKKKD 119

  Fly   148 KECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKNLEQETLS 212
            .:...|...::..|::.|:.....|.|.::...|:.:|.:...:|.:........:|.||.|||.
Zfish   120 GDLAAALVRIKDLEAQYNKNEAALNTALSENASLSAELADLKAQLAKAEDAHGVAKKQLEVETLM 184

  Fly   213 RVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEE 277
            ||||||..|||.|||.|:..:..:|:.|:||..:....|:|..:..:|:.||.|:||:||.|:||
Zfish   185 RVDLENRCQSLTEELEFRKSMFDEEVRETRRRHEKRMVEVDSGMQQDYEFKLSQALQDLRKQHEE 249

  Fly   278 QMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQANADLNAR 342
            |:||.::|:|..::.|:...:.::.....:...:.|||:...|||:.|:..::.|::..:....|
Zfish   250 QVQIYKEELQHTFKAKLDNAKVSSDLNDKAVLTAREELQEAHVRIEGLSYQLSALQKQASAAEER 314

  Fly   343 IRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYDKLLVGEE 407
            ||:||..|.:||:::.:::|..|:|:..:||.|.|||.|||:|:|:|::||:||.||.|||.|||
Zfish   315 IRELEGLLSSDRDKYRRQLDAKEREMAEMRECMQQQLNEYQELLDVKLALDMEINAYRKLLEGEE 379

  Fly   408 ARLNITPATNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYYV----SAS 468
            .||.::|:.::....|      .:|.::.|..:.|:..||||..::||   |.|...|    .|.
Zfish   380 DRLKLSPSPSSRVTVS------RTTASSTSASSRSSRAKRKRVELEES---STAGPKVQISQQAE 435

  Fly   469 AKGNVEIKEIDPEGKFVRLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSVRIEPNGVITVWS 533
            |.|:|.|:|||.|||.|.|.|...::.::|.|:|:|.|.: |....|||.....::....:||||
Zfish   436 ASGSVSIEEIDLEGKSVTLRNNSDKDQSLGSWRLKRQIGD-GEEIVYKFSPKFVLKAGQTVTVWS 499

  Fly   534 ADTKASHEPPSSLVMKSQ-KWVSADNTRTILLNSEGEAVANLDRIKRIVSQHTSSSRLSRRRSVT 597
            ||...||.|||.|:.||| .|.:.:|..|:|:||.||.||     ||.|:           :||.
Zfish   500 ADAGMSHSPPSDLLWKSQSSWGTGENILTLLVNSSGEDVA-----KRTVT-----------KSVI 548

  Fly   598 AVD---------GNEQLYHQQGDPQ-QSNEKCAIM 622
            .::         |:|.|:||||||: |...:||:|
Zfish   549 EMENGDDEEGDFGDEDLFHQQGDPKTQRARECAVM 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	140/354 (40%)
		Ax_dynein_light	<283..377	CDD:287215	25/93 (27%)
		LTD	466..572	CDD:279300	46/106 (43%)
lmnb2	NP_571077.2	Filament	25..381	CDD:278467	140/355 (39%)
		DUF342	<300..371	CDD:302792	28/70 (40%)
		LTD	433..542	CDD:279300	49/114 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1815
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7818
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1927
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm6402
orthoMCL	1	0.900	-	-		OOG6_103212
Panther	1	1.100	-	-	O	PTHR45721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2618
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010