DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lam and Lmnb2

DIOPT Version :9

Sequence 1:	NP_001245892.1	Gene:	Lam / 33782	FlyBaseID:	FBgn0002525	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001292164.1	Gene:	Lmnb2 / 299625	RGDID:	1563803	Length:	616	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	225/622 - (36%)
Similarity:	353/622 - (56%)	Gaps:	17/622 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATPQPGNTSTPRPPSAGPQPPPPSTHSQTASSPLSPTRHSRVAEKVELQNLNDRLATYIDRVRNL 75
            :.|.||:::.|...:......||...|.|   ||||||.||:.||.||:.||||||.||||||.|
  Rat     2 SAPDPGSSADPPAAATAMASLPPRAGSAT---PLSPTRLSRLQEKEELRELNDRLAHYIDRVRAL 63

  Fly    76 ETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEELK 140
            |.||.:|.:.:....:..|||.:.||.::|:||.:.||:||:|||:|||.:|:|.::..|.||.|
  Rat    64 ELENDKLLLRISEKEEVTTREVSGIKTLYESELADARRVLDETARERARLQIEIGKVQAELEEAK 128

  Fly   141 NKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETRKN 205
            ....|:..|.|.|.|.|:..||..:....:...|..|:..|..::.|...:|.:........:|.
  Rat   129 KSAKKREGELTVARGRVKDLESLFHRSEAELAAALGDKHVLETEVAELRAQLAKAEDGHAVAKKQ 193

  Fly   206 LEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAKLKQSLQE 270
            ||:|||.||||||..|||:|||:|...:..:|:.|:||..:....|:|.....|||.|:.|:|:|
  Rat   194 LEKETLMRVDLENHCQSLQEELAFSKSVFEEEVQETRRRHERHLVEVDSSRQQEYDFKIAQALEE 258

  Fly   271 LRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINELEQA 335
            ||:|::||:::.|.|::..|:.|:...:..:.:...:...:.|||:..|:|:::|:..::.|::.
  Rat   259 LRSQHDEQVRLYRLELEQTYQAKLDNTKLISDQNDKAARAAREELKEARMRVESLSYQLSGLQKQ 323

  Fly   336 NADLNARIRDLERQLDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSLDLEIAAYD 400
            .:.....||:||..|..:|::....:|..|:|:..:|:.|.|||.|||:|:|||::||:||.:|.
  Rat   324 ASAAEDHIRELEEALAGERDKFRNMLDAKEQEMAEVRDAMQQQLAEYQELLDIKLALDMEICSYR 388

  Fly   401 KLLVGEEARLNITPA-TNTATVQSFSQSLRNSTRATPSRRTPSAAVKRKRAVVDESEDHSVADYY 464
            |||.|||.||.::|: ::..|:...:.|..:|:.:...........||:|...:::.....:...
  Rat   389 KLLEGEEERLKLSPSPSSRVTISLATSSSSSSSSSGVGMSLGRGRSKRQRLETEDTPGSPSSASS 453

  Fly   465 VS--------ASAKGNVEIKEIDPEGKFVRLFNKGSEEVAIGGWQLQRLINEKGPSTTYKFHRSV 521
            ||        |.|.|.|.|.|:|.||:||||.|...::.::|.|::::.:.| |....|||....
  Rat   454 VSSGSRLAQQAGATGVVNIDEVDLEGRFVRLKNSSDKDQSLGNWRIKKQVLE-GEDIAYKFTPKY 517

  Fly   522 RIEPNGVITVWSADTKASHEPPSSLVMKSQ-KWVSADNTRTILLNSEGEAVANLDRIKRIVSQHT 585
            .:.....:|||:|...|:|.|||:||.|:| .|.|.:|.||:|:|::||.||........|..|.
  Rat   518 VLRAGQTVTVWAAGAGATHSPPSTLVWKNQSSWGSGENFRTVLVNADGEEVAVQAAKPPSVQGHE 582

  Fly   586 SSSRLSRRRSVTAVDGNEQLYHQQGDPQQSNEKCAIM 622
            |.   .......|..|.|.|:||||||:.::..|.:|
  Rat   583 SR---EEEEEAEAEFGEEDLFHQQGDPRTTSRGCRMM 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lam	NP_001245892.1	Filament	54..409	CDD:278467	138/354 (39%)
		Ax_dynein_light	<283..377	CDD:287215	22/93 (24%)
		LTD	466..572	CDD:279300	44/114 (39%)
Lmnb2	NP_001292164.1	Filament	41..397	CDD:278467	138/355 (39%)
Lmnb2	NP_001292164.1	LTD	463..570	CDD:279300	44/107 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1753
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7818
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1917
OMA	1	1.010	-	-		QHG48052
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm9150
orthoMCL	1	0.900	-	-		OOG6_103212
Panther	1	1.100	-	-	O	PTHR45721
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840